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MSDS   | : | Benzoic acid,
p-(3-hydroxy-5-hydroxymethyl-2-methyl-4-pyridylmethyl
)amino-, 2- diethylaminoethyl ester, dihydrochloride
| CAS   | : | 73713-65-2 | SYNONYMS   | : | * Pyridoxyl-4-procain dihydrochlorid
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*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : DH2220000
CHEMICAL NAME : Benzoic acid,
p-(3-hydroxy-5-hydroxymethyl-2-methyl-4-pyridylmethyl
)amino-, 2- diethylaminoethyl ester, dihydrochloride
CAS REGISTRY NUMBER : 73713-65-2
LAST UPDATED : 197906
DATA ITEMS CITED : 10
MOLECULAR FORMULA : C21-H29-N3-O4.2Cl-H
MOLECULAR WEIGHT : 460.45
WISWESSER LINE NOTATION : T6NJ B1 CQ D1MR DVO2N2&2& E1Q &GH 2
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Pyridoxyl-4-procain dihydrochlorid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5900 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 11,922,1961
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1250 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 11,922,1961
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 120 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 11,922,1961
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 6900 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 11,922,1961
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 602 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 11,922,1961
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 86 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 11,922,1961
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 78 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - changes in structure or function of salivary glands
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 11,922,1961
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 335 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - changes in structure or function of salivary glands
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 11,922,1961
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 130 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory
change
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 11,922,1961
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Bird - pigeon
DOSE/DURATION : 160 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 11,922,1961
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Benzoic acid, 4-(4-hydroxybutyl)-
| 58973-64-1 |
Benzoic acid, p-hydroxy-, butyl ester
| 94-26-8 |
Benzoic acid, 3,4-diiodo-
| 35674-20-5 |
Benzoic acid, p-hydroxy-, butyl ester, sodium salt
| 36457-20-2 |
Benzoic acid, p-((4-hydroxycarbaniloyl)oxy)-, methylester, ester with bis(1-aziridinyl) phosphinate
| 41363-21-7 |
Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester
| 552-94-3 |
Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester,monosodium salt
| 23520-54-9 |
Benzoic acid, 2-hydroxy-,2-(7-chloro-2H-1,4-benzothiazin-3-yl)hydrazide
| 78959-18-9 |
Benzoic acid, 4-hydroxy-,2-(7-chloro-2H-1,4-benzothiazin-3-yl)hydrazide
| 78959-19-0 |
Benzoic acid, 2-hydroxy-,2-(((2-chloroethyl)nitrosoamino)carbonyl)hydrazide
| 147217-63-8 |
Benzoic acid, 2-hydroxy-,(1-(2-chlorophenyl)ethylidene)hydrazide, (E)-
| 133662-01-8 |
Benzoic acid, 2-hydroxy-, cyclohexyl ester
| 25485-88-5 |
Benzoic acid, p-hydroxy-, decyl ester
| 69679-30-7 |
Benzoic acid,4-(((4,5-dihydro-4-oxo-3H-1,2,3-triazino(5,4-b)indol-3-yl)imino)methyl)-
| 139953-77-8 |
Benzoic acid, 3,5-diiodo-
| 19094-48-5 |
Benzoic acid, 4-hydroxy-3,5-dimethoxy-
| 530-57-4 |
Benzoic acid, o-hydroxy-,3-(2,3-dimethylpiperidino)propyl ester, hydrochloride
| 67049-52-9 |
Benzoic acid, o-hydroxy-,3-(2,4-dimethylpiperidino)propyl ester, hydrochloride
| 67049-53-0 |
Benzoic acid, o-hydroxy-,3-(2,5-dimethylpiperidino)propyl ester, hydrochloride
| 67032-02-4 |
Benzoic acid, o-hydroxy-,3-(2,6-dimethylpiperidino)propyl ester, hydrochloride
| 66591-54-6 |
Benzoic acid, 2-hydroxy-, compd. with4,6-dimethyl-N-(3,4,5-trimethoxyphenyl)-2-pyrimidinamine
| 94696-72-7 |
Benzoic acid, 2-hydroxy-,1,4-dioxaspiro(4.5)dec-2-ylmethyl ester
| 59902-29-3 |
Benzoic acid,4-((2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)acetyl)-
| 70780-35-7 |
Benzoic acid,2-(2-hydroxy-1,4-dioxo-4-phenyl-2-butenyl)hydrazide,(Z)-
| 124928-27-4 |
Benzoic acid, 4-hydroxy-, diphenylsilylene ester
| 129459-90-1 |
Benzoic acid, 2-(3,5-diiodobenzenesulfonamido)-
| 129459-90-1 |
Benzoic acid, p-hydroxy-, dodecyl ester
| 2664-60-0 |
Benzoic acid, p-hydroxy-, ester with3-hydroxy-1-methyl-3-piperidyl phenyl ketone,monohydrochloride, (+-), hemihydrate
| 33422-53-6 |
Benzoic acid, p-hydroxy-, ester with(3-hydroxypropyl)guanidine, monohydrochloride
| 19623-22-4 |
Benzoic acid, o-(2-hydroxyethoxy)-
| 19623-22-4 |
Benzoic acid, 2-((2-hydroxyethyl)amino)-
| 25784-00-3 |
Benzoic acid,2-(((2-hydroxyethyl)amino)carbonyl)-3,4,5,6-tetraiodo-
| 25784-00-3 |
Benzoic acid,4-(((2-hydroxyethyl)amino)carbonyl)-2,3,5,6-tetraiodo-
| 34737-08-1 |
Benzoic acid, o-(2-hydroxyethyl)-,((1,2-dihydro-5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-2,7-(epoxypentadeca(1,11,13)trie nimino)naphtho(2,1-b)furan-8-yl)methylene)hydrazide, 21-acetate
| 38546-25-7 |
Benzoic acid, p-hydroxy-, ethyl ester
| 120-47-8 |
Benzoic acid, p-hydroxy-, ethyl ester, sodium deriv.
| 35285-68-8 |
Benzoic acid, 4-(3,5-diiodobenzenesulfonamido)-
| 35285-68-8 |
Benzoic acid,4-(((2-hydroxyethyl)methylamino)carbonyl)-2,3,5,6-tetraiodo-
| 34737-11-6 |
Benzoic acid,2-(5-((4-(2-hydroxyethyl)-1-piperazinyl)carbonyl)-1,3-benzodioxol-4-yl)-3, 4,5- trimethoxy-,2-methylphenyl ester
| 156809-19-7 |
Benzoic acid, p-hydroxy-, heptyl ester
| 1085-12-7 |
Benzoic acid, p-hydroxy-, heptyl ester, dihydrogenphosphate
| 27864-56-8 |
Benzoic acid, p-hydroxy-, hexyl ester
| 1083-27-8 |
Benzoic acid,2-hydroxy-5-(2-(2-hydroxybenzoyl)ethenyl)-
| 1083-27-8 |
Benzoic acid,2-hydroxy-5-(2-(2-hydroxy-5-iodobenzoyl)ethenyl)-
| 1083-27-8 |
Benzoic acid,2-hydroxy-4-((4-hydroxy-2-methoxy-3,5,6-trimethylbenzoyl)oxy)-3,5,6-trimet hyl-,4-carboxy-3-methoxy-2,5,6-trimethylphenyl ester
| 158792-23-5 |
Benzoic acid,p-(3-hydroxy-5-hydroxymethyl-2-methyl-4-pyridylmethyl)amino-, 2- diethylaminoethyl ester, dihydrochloride
| 73713-65-2 |
Benzoic acid,2-hydroxy-5-(6-hydroxy-4-oxo-4H-1-benzopyran-2-yl)-
| 126342-65-2 |
Benzoic acid, 3,5-diiodo-4-ethoxy-, hydrazide
| 23964-38-7 |
Benzoic acid,2-hydroxy-5-(1-hydroxy-2-(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1- piperidinyl)ethyl)-, methyl ester
| 74406-01-2 |
Benzoic acid,2-hydroxy-5-(((4-hydroxyphenyl)amino)carbonyl)-,methyl ester
| 25334-08-1 |
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