RTECS NUMBER : DH2450000
CHEMICAL NAME : Benzoic acid, p-hydroxy-, methyl ester
CAS REGISTRY NUMBER : 99-76-3
BEILSTEIN REFERENCE NO. : 0509801
REFERENCE : 4-10-00-00360 (Beilstein Handbook Reference)
LAST UPDATED : 199701
DATA ITEMS CITED : 13
MOLECULAR FORMULA : C8-H8-O3
MOLECULAR WEIGHT : 152.16
WISWESSER LINE NOTATION : QR DVO1
COMPOUND DESCRIPTOR : Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Abiol
* Aseptoform
* p-Hydroxybenzoic acid methyl ester
* Maseptol
* Metaben
* Methylben
* Methyl chemosept
* Methyl ester of p-hydroxybenzoic acid
* Methylester kyseliny p-hydroxybenzoove
* Methyl p-hydroxybenzoate
* Methyl p-oxybenzoate
* Methylparaben
* Methyl parahydroxybenzoate
* Methyl parasept
* Metoxyde
* Moldex
* Nipagin
* Nipagin M
* p-Oxybenzoesauremethylester
* Paridol
* Preserval M
* Septos
* Solbrol
* Solbrol M
* Tegosept M
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher
information, see JTCTDW. Volume(issue)/page/year: 4(2),185,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >8 gm/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - ataxia
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see
JPMSAE. Volume(issue)/page/year: 45,260,1956
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 960 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see
JPMSAE. Volume(issue)/page/year: 45,260,1956
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 128,135,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 53A,81,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 53A,81,1974
** MUTATION DATA **
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 125 mg/L/27H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 66,277,1979
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Fibroblast
DOSE/DURATION : 500 mg/L
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year:
(96),55,1978
*** REVIEWS ***
TOXICOLOGY REVIEW
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 4,575,1954
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80461
No. of Facilities: 4469 (estimated)
No. of Industries: 33
No. of Occupations: 50
No. of Employees: 57029 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80461
No. of Facilities: 15369 (estimated)
No. of Industries: 94
No. of Occupations: 117
No. of Employees: 590361 (estimated)
No. of Female Employees: 398916 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***
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