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MSDS  : Benzoic acid, p-hydroxy-, methyl ester
CAS  : 99-76-3
SYNONYMS  : * Abiol * Aseptoform * p-Hydroxybenzoic acid methyl ester * Maseptol * Metaben * Methylben * Methyl chemosept * Methyl ester of p-hydroxybenzoic acid * Methylester kyseliny p-hydroxybenzoove * Methyl p-hydroxybenzoate * Methyl p-oxybenzoate * Methylparaben * Methyl parahydroxybenzoate * Methyl parasept * Metoxyde * Moldex * Nipagin * Nipagin M * p-Oxybenzoesauremethylester * Paridol * Preserval M * Septos * Solbrol * Solbrol M * Tegosept M
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : DH2450000
CHEMICAL NAME : Benzoic acid, p-hydroxy-, methyl ester
CAS REGISTRY NUMBER : 99-76-3
BEILSTEIN REFERENCE NO. : 0509801
REFERENCE : 4-10-00-00360 (Beilstein Handbook Reference)
LAST UPDATED : 199701
DATA ITEMS CITED : 13
MOLECULAR FORMULA : C8-H8-O3
MOLECULAR WEIGHT : 152.16
WISWESSER LINE NOTATION : QR DVO1
COMPOUND DESCRIPTOR : Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Abiol
* Aseptoform
* p-Hydroxybenzoic acid methyl ester
* Maseptol
* Metaben
* Methylben
* Methyl chemosept
* Methyl ester of p-hydroxybenzoic acid
* Methylester kyseliny p-hydroxybenzoove
* Methyl p-hydroxybenzoate
* Methyl p-oxybenzoate
* Methylparaben
* Methyl parahydroxybenzoate
* Methyl parasept
* Metoxyde
* Moldex
* Nipagin
* Nipagin M
* p-Oxybenzoesauremethylester
* Paridol
* Preserval M
* Septos
* Solbrol
* Solbrol M
* Tegosept M

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher
information, see JTCTDW. Volume(issue)/page/year: 4(2),185,1971

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >8 gm/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - ataxia
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see
JPMSAE. Volume(issue)/page/year: 45,260,1956

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 960 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see
JPMSAE. Volume(issue)/page/year: 45,260,1956

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 128,135,1960

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 53A,81,1974

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 53A,81,1974

** MUTATION DATA **

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 125 mg/L/27H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 66,277,1979

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Fibroblast
DOSE/DURATION : 500 mg/L
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year:
(96),55,1978

*** REVIEWS ***

TOXICOLOGY REVIEW
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 4,575,1954

*** U.S. STANDARDS AND REGULATIONS ***

EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80461
No. of Facilities: 4469 (estimated)
No. of Industries: 33
No. of Occupations: 50
No. of Employees: 57029 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80461
No. of Facilities: 15369 (estimated)
No. of Industries: 94
No. of Occupations: 117
No. of Employees: 590361 (estimated)
No. of Female Employees: 398916 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY


*** END OF RECORD ***
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NAMECAS
Benzoic acid,2-hydroxy-4-(((4-hydroxyphenyl)amino)oxoacetyl)amino- 93628-86-5
Benzoic acid,5-hydroxy-2-((4-hydroxy-3-(trifluoromethyl)phenyl)amino)- 76874-95-8
Benzoic acid,5-hydroxy-2-((4-hydroxy-3-(trifluoromethyl)phenyl)amino)-, 2-(2-hydroxyethoxy) ethyl ester 76874-97-0
Benzoic acid, 2-hydroxy-, compd. with 1H-imidazole(1:1) 36364-49-5
Benzoic acid, 2-hydroxy-3-(1H-imidazol-4-ylmethyl)-,hydrazide 127190-49-2
Benzoic acid, 4-(3-hydroxy-1H-indazol-1-yl)-, butylester 20943-48-0
Benzoic acid, 2-hydroxy-5-iodo-, sodium salt 20943-48-0
Benzoic acid, p-hydroxy-, isobutyl ester 4247-02-3
Benzoic acid, 3,5-diiodo-4-ethoxy-,2-isopropylhydrazide, monohydrochloride 24032-10-8
Benzoic acid, p-hydroxy-, isopropyl ester 4191-73-5
Benzoic acid, o-(2-hydroxy-4-methoxybenzoyl)- 4756-45-0
Benzoic acid, 2-hydroxy-3-methoxy-,2-(diethylamino)ethyl ester, hydrochloride 24022-35-3
Benzoic acid, 2-hydroxy-3-methoxy-,2-(dimethylamino)ethyl ester, hydrochloride 23958-95-4
Benzoic acid, 4-hydroxy-3-methoxy-,4,9-epoxy-4-beta,12,14,16-beta,17,20-hexahydroxycevan-3- alpha-yl ester, 4-acetate 23958-95-4
Benzoic acid, 4-hydroxy-3-methoxy-,8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester,hydrochloride, endo- 23958-95-4
Benzoic acid, 4-hydroxy-3-methoxy-, methyl ester 3943-74-6
Benzoic acid, 2-hydroxy-5-methoxy-, octyl ester 25485-92-1
Benzoic acid,2-hydroxy-5-(((4-methoxyphenyl)amino)carbonyl)-,ethyl ester 28092-08-2
Benzoic acid,4-(2-(2-(4-hydroxy-3-methoxyphenyl)ethenyl)-7-nitro-4-oxo-3(4H)-quinazolin yl)-, methyl ester 78356-76-0
Benzoic acid, 3,5-diiodo-4-ethoxy-,2-isopropylidenehydrazide 23959-64-0
Benzoic acid,4-(((4-hydroxy-3-methoxyphenyl)methylene)amino)- 63098-82-8
Benzoic acid,2,2'-((2-((4-hydroxy-3-methoxyphenyl)methylene)-1,3-dioxo-1,3-propanediyl) diimino)bis- 100093-49-0
Benzoic acid,2-(((5-((4-hydroxy-3-methoxyphenyl)methylene)-4-oxo-2-thioxo-3-thiazolidin yl) methyl)amino)- 89752-53-4
Benzoic acid,4-(((5-((4-hydroxy-3-methoxyphenyl)methylene)-4-oxo-2-thioxo-3-thiazolidin yl) methyl)amino)- 89752-55-6
Benzoic acid, 2-hydroxy-5-methoxy-, 2-phenylethylester 25485-93-2
Benzoic acid,2-hydroxy-5-((4-(((6-methoxy-3-pyridazinyl)amino)sulfonyl)phenyl)azo)- 22933-72-8
Benzoic acid, 2-hydroxy-6-methyl-,(5-((3-acetylphenyl)amino)-4-amino-3-(((dimethylamino)carbonyl)amino)-1,2-dihydroxy-3-ethyl-2-methylcyclopentyl)methyl ester, (1S-(1-alpha,2-beta,3-alpha,4-alpha,5-beta))- 104820-96-4
Benzoic acid, 2-hydroxy-,2-((methylamino)thioxomethyl)hydrazide 63224-32-8
Benzoic acid, 4-hydroxy-3-(3-methyl-2-butenyl)-,allyl ester 63224-32-8
Benzoic acid, 4-hydroxy-3-(3-methyl-2-butenyl)-,butyl ester 63224-32-8
Benzoic acid, 3,5-diiodo-4-hydroxy- 618-76-8
Benzoic acid, 2-hydroxy-3-methyl-,2-(diethylamino)ethyl ester 78330-01-5
Benzoic acid, 2-hydroxy-3-methyl-,2-(diethylamino)ethyl ester, hydrochloride 67032-04-6
Benzoic acid, p-hydroxy-, methyl ester 99-76-3
Benzoic acid, p-hydroxy-, methyl ester, sodium deriv. 5026-62-0
Benzoic acid, 2-hydroxy-6-methyl-,(5-((3-(hydroxyacetyl)phenyl)amino)-4-amino-3-(((dimethylamino)carbonyl)amino)-1,2-dihydroxy-3-(1-hydroxyethyl)-2-methyl cyclopentyl) methyl ester,(1S-(1-alpha,2-beta,3-alpha,3(R*),4-alpha,5-beta))- 104820-97-5
Benzoic acid,3-(((1-(hydroxymethyl)-2-(methylamino)-2-oxoethyl)amino)carbonyl)-5-((methoxyacetyl)amino)-2,4,6-triiodo-, (+-)-, compd.with 1-deoxy-1-(methylamino)glucitol (1:1) 104820-97-5
Benzoic acid, 2-hydroxy-3-methyl-, methyl ester 23287-26-5
Benzoic acid, 2-hydroxy-,2-methyl-4-oxo-4H-pyran-3-yl ester 147249-34-1
Benzoic acid, 3-hydroxy-, 3-methyl-1-pentyn-3-ylester 147249-34-1
Benzoic acid,2-hydroxy-5-(((2-methylphenyl)amino)carbonyl)-, ethylester 38507-88-9
Benzoic acid, 3,5-diiodo-4-hydroxy-, acetate 38507-88-9
Benzoic acid,2-hydroxy-5-(((3-methylphenyl)amino)carbonyl)-, ethylester 38507-89-0
Benzoic acid,2-hydroxy-5-(((4-methylphenyl)amino)carbonyl)-, ethylester 38507-90-3
Benzoic acid,2-(2-(2-hydroxy-5-methylphenyl)-2-methyl-4-oxo-3-thiazolidinyl)- 60121-35-9
Benzoic acid, m-hydroxy-,3-(2'-methylpiperidino)propyl ester 63916-85-8
Benzoic acid, o-hydroxy-,3-(2'-methylpiperidino)propyl ester 63916-86-9
Benzoic acid, p-hydroxy-,3-(2'-methylpiperidino)propyl ester 63916-87-0
Benzoic acid, m-hydroxy-,3-(2-methylpiperidino)propyl ester, hydrochloride 67032-05-7
Benzoic acid, p-hydroxy-,3-(2-methylpiperidino)propyl ester, hydrochloride 67032-06-8

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