*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : DL5950000
CHEMICAL NAME : Benzothiazole, 2-(morpholinothio)-
CAS REGISTRY NUMBER : 102-77-2
BEILSTEIN REFERENCE NO. : 0191684
REFERENCE : 4-27-00-01868 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 17
MOLECULAR FORMULA : C11-H12-N2-O-S2
MOLECULAR WEIGHT : 252.37
WISWESSER LINE NOTATION : T56 BN DSJ CS- AT6N DOTJ
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* AMAX
* 2-Benzothiazolyl N-morpholino sulfide
* 2-Benzothiazolylsulfenyl morpholine
* 4-(2-Benzothiazolylthio)morpholine
* 2-(Morpholinothio)benzothiazole
* Morpholinylmercaptobenzothiazole
* 2-(4-Morpholinylthio)benzothiazole
* N-Oxydiethyl-2-benzthiazolsulfenamid
* N-(Oxydiethylene)benzothiazole-2-sulfenamide
* Santocure MOR
* Sulfenamide M
* Sulfenax mob
* USAF CY-7
* Vulcafor BSM
* Vulkacit MOZ
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-
1990- Volume(issue)/page/year: 15(Suppl 1),S74,1996
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg/24H
REACTION SEVERITY : Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1099,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-
1990- Volume(issue)/page/year: 15(Suppl 1),S74,1996
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1870 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Skin and Appendages - hair
REFERENCE :
20ZJAG "Toksikologiia Novykh Khimicheskikh Veshchesty, Vnedriaemykh V,"
Izrael'son, Z.I., ed., Rezinovuiu I Shinnaiu Promyshlennost, 1968
Volume(issue)/page/year: -,64,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1520 mg/kg/15w-I
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other Enzymes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 6(7),28,1962
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 464 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB223-159
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE : 400 mg/kg
SEX/DURATION : female 4-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation).
Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
10013) V.41- 1956- Volume(issue)/page/year: 93,107,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE : 800 mg/kg
SEX/DURATION : male 2 day(s) pre-mating
female 2 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation).
Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
10013) V.41- 1956- Volume(issue)/page/year: 93,107,1982
** MUTATION DATA **
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 10 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5,193,1983
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 15 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5,193,1983
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - mouse Embryo
DOSE/DURATION : 200 ug/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5,193,1983
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 10 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5,193,1983
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X7192
No. of Facilities: 271 (estimated)
No. of Industries: 5
No. of Occupations: 25
No. of Employees: 14076 (estimated)
No. of Female Employees: 1420 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9173;8EHQ-0892-9289
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***
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| ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| | NAME | CAS |
|
Benzothiazole,5-methoxy-2-(beta-(1-pyrrolidinyl)-p-phenetidino)-
| 38519-94-7 |
|
Benzothiazole, 2-methyl-
| 120-75-2 |
|
Benzothiazole, 2-(methylamino)-
| 16954-69-1 |
|
Benzothiazole, 6-((p-(methylamino)phenyl)azo)-
| 16954-69-1 |
|
Benzothiazole,2-(2-((1-methylethyl)thio)-4-thiazolyl)-
| 67723-95-9 |
|
Benzothiazole, 2-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-
| 43193-11-9 |
|
Benzothiazole, 2-(3-methyl-1H-pyrazol-5-yl)-
| 43193-11-9 |
|
Benzothiazole, 2-(2-(methylthio)-4-thiazolyl)-
| 67723-92-6 |
|
Benzothiazole, 2-(morpholinothio)-
| 102-77-2 |
|
p-Benzoquinone,2,5-bis(1-aziridinyl)-3,6-bis(2-methoxyethoxy)-
| 800-24-8 |
|
p-Benzoquinone, 2,6-dimethoxy-3-(hydroxymethyl)-,acetate (ester)
| 40870-53-9 |
|
Benzothiazole, 2-(4-morpholinyldithio)-
| 95-32-9 |
|
Benzothiazole, 6-nitro-2-(p-nitrobenzoylamino)-
| 64036-74-4 |
|
Benzothiazole, 2-(2-nitrophenyl)-
| 6269-45-0 |
|
Benzothiazole, 2-pentylthio-
| 73713-86-7 |
|
Benzothiazole, 2-phenyl-
| 883-93-2 |
|
Benzothiazole, 6-((p-piperidinophenyl)azo)-
| 84713-38-2 |
|
Benzothiazole, 2-(piperidinothio)-
| 26773-65-9 |
|
3(2H)-Benzothiazolepropanamide,2-imino-6-(trifluoromethoxy)-
| 130997-38-5 |
|
3(2H)-Benzothiazolepropanenitrile,2-imino-6-(trifluoromethoxy)-, ethanedioate (1:1)
| 130997-37-4 |
|
3-Benzothiazolepropanesulfonic acid,2-(4-(3-ethyl-4-oxo-2-thioxo-5-thiazolidinylidene)-2-butenylidene)-
| 64285-53-6 |
|
p-Benzoquinone,2,3-dimethoxy-5-methyl-6-(3,7,11,15,19,23,27,31,35-nonamethyl-2,6,10,14,18,22,26,30,34-hexatriacontanonaenyl)-
| 303-97-9 |
|
3(2H)-Benzothiazolepropanoic acid,2-(4-(3-(2-carboxyethyl)-4-oxo-2-thioxo-5-thiazolidinylidene)-2-butenylidene)-6-methyl-
| 62883-67-4 |
|
5-Benzothiazolepropionic acid, 2-phenyl-
| 52321-54-7 |
|
Benzothiazole, 2-(2-(propylthio)-4-thiazolyl)-
| 67723-94-8 |
|
Benzothiazole, 2-(2-pyridyl)-
| 716-80-3 |
|
Benzothiazole, 6-((p-(1-pyrrolidinyl)phenyl)azo)-
| 716-80-3 |
|
2-Benzothiazolesulfenamide
| 2801-21-0 |
|
2-Benzothiazolesulfenamide, N-tert-butyl-
| 95-31-8 |
|
2-Benzothiazolesulfenamide, N-cyclohexyl-
| 95-33-0 |
|
2-Benzothiazolesulfenamide, N,N-dicyclohexyl-
| 4979-32-2 |
|
2-Benzothiazolesulfenamide, N,N-diisopropyl-
| 95-29-4 |
|
p-Benzoquinone, 2,3-dimethyl-
| 526-86-3 |
|
2-Benzothiazolesulfonamide, 6-ethoxy-
| 452-35-7 |
|
Benzothiazolesulfonamide, N-(1-methylethyl)-
| 63904-87-0 |
|
7-Benzothiazolesulfonic acid,2-(p-aminophenyl)-6-methyl-
| 130-17-6 |
|
7-Benzothiazolesulfonic acid,2,2'-(1-triazene-1,3-diyldi-4,1-phenylene)bis(6-methyl-, disodium salt
| 1829-00-1 |
|
Benzothiazole, 4,5,6,7-tetrahydro-2-amino-
| 2933-29-1 |
|
Benzothiazole, 4,5,6,7-tetrahydro-,1,2-ethanedisulfonate (2:1)
| 31784-85-7 |
|
Benzothiazole, 4,5,6,7-tetrahydro-6-(methylamino)-
| 70590-58-8 |
|
Benzothiazole,4,5,6,7-tetrahydro-2-(2-(5-nitrofuryl)vinyl)-
| 30311-48-9 |
|
Benzothiazole,4,5,6,7-tetrahydro-2-(2-(5-nitrofuryl)vinyl)-,3-oxide
| 40019-78-1 |
|
2-Benzothiazolethiol
| 149-30-4 |
|
p-Benzoquinone, 2,5-dimethyl-
| 137-18-8 |
|
2-Benzothiazolethiol, 6-amino-
| 7442-07-1 |
|
2-Benzothiazolethiol, 5-chloro-
| 5331-91-9 |
|
2-Benzothiazolethiol, 6-ethoxy-
| 120-53-6 |
|
Benzothiazolethiol, 2-ethoxycarbonylmethyl-
| 64036-42-6 |
|
Benzothiazolethiol, 2-methyl-
| 64036-43-7 |
|
2-Benzothiazolethiol, 6-nitro-
| 4845-58-3 |
|
|