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MSDS  : Butane, 1-chloro-
CAS  : 109-69-3
SYNONYMS  : * Butyl chloride * n-Butyl chloride * 1-Chlorobutane * Chlorure de butyle * NCI-C06155 * n-Propylcarbinyl chloride
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : EJ6300000
CHEMICAL NAME : Butane, 1-chloro-
CAS REGISTRY NUMBER : 109-69-3
BEILSTEIN REFERENCE NO. : 1730909
REFERENCE : 4-01-00-00246 (Beilstein Handbook Reference)
LAST UPDATED : 199806
DATA ITEMS CITED : 21
MOLECULAR FORMULA : C4-H9-Cl
MOLECULAR WEIGHT : 92.58
WISWESSER LINE NOTATION : G4
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Butyl chloride
* n-Butyl chloride
* 1-Chlorobutane
* Chlorure de butyle
* NCI-C06155
* n-Propylcarbinyl chloride

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2670 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 10,61,1954

TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 8000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 10,61,1954

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VRDEA5 Vrachebnoe Delo. Medical Practice. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) No.1- 1918- Volume(issue)/page/year: (7),105,1979

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 5600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 44(3),11,1979

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,745,1969

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VRDEA5 Vrachebnoe Delo. Medical Practice. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) No.1- 1918- Volume(issue)/page/year: (7),105,1979

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 364 mg/kg/26W-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 44(3),11,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10500 mg/kg/14D-I
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-312,1986

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 32500 mg/kg/13W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-312,1986

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 21 gm/kg/14D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-312,1986

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 65 gm/kg/13W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-312,1986

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 13927 mg/kg
SEX/DURATION : female 1-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 44(3),11,1979

** MUTATION DATA **

TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 500 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-312,1986

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-RUSSIA:STEL 0.5 mg/m3;Skin JAN 1993

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3168
No. of Facilities: 33 (estimated)
No. of Industries: 2
No. of Occupations: 4
No. of Employees: 3202 (estimated)
No. of Female Employees: 880 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

On EPA IRIS database

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

NTP Carcinogenesis Studies (gavage);no evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-312,86


*** END OF RECORD ***
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NAMECAS
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1-Butanamine, N-nitroso-N-propyl- 25413-64-3
Butanediamine, N,N,N',N'-tetramethyl- 27195-72-8
1-Butanaminium,N-(3-(2-(butyldimethylammonio)ethoxy)-3-oxopropyl)-N,N-dimethyl-, diiodide 27195-72-8
2-Butanaminium,1-(3-(diethylmethylammonio)-3-oxopropoxy)-N,N,N-trimethyl-, diiodide 27195-72-8
Biuret, 1-butyl-2,4-dithio-1-phenyl- 27195-72-8
2-Butanaminium,N,N-dimethyl-4-(2-(dimethylethylammonio)ethoxy)-N-ethyl-4-oxo-, diiodide 27195-72-8
2-Butanaminium,N,N-dimethyl-1-(3-(dimethylethylammonio)-1-oxopropoxy)-N-ethyl-, diiodide 27195-72-8
1-Butanaminium,4-((2,6-dimethylphenyl)methylamino)-N,N,N-triethyl-,bromide 27195-72-8
2-Butanaminium,4,4'-((2,5-dioxo-1,4-cyclohexadiene-1,4-diyl)imino)bis(N,N-diethyl-N-methy l-, diiodide, (-)- 27195-72-8
2-Butanaminium,4,4'-((2,5-dioxo-1,4-cyclohexadiene-1,4-diyl)imino)bis(N,N-diethyl-N-methy l-, diiodide, (+)- 27195-72-8
2-Butanaminium,4,4'-((2,5-dioxo-1,4-cyclohexadiene-1,4-diyl)imino)bis(N,N-diethyl-N-methy l-, diiodide, (+-)- 27195-72-8
1-Butanaminium,N-ethyl-N,N-dimethyl-3-((tricyclo(3.3.1.1(sup3,7))dec-1-ylcarbonyl)oxy)-, iodide 54099-18-2
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2-Butanaminium,4-oxo-N,N,N,2-tetramethyl-4-(2-(trimethylammonio)ethoxy)-, diiodide 41549-91-1
2-Butanaminium,1-(1-oxo-3-(trimethylammonio)propoxy)-N,N,N-trimethyl-, diiodide 41549-91-1
Biuret, 1-(p-butylphenyl)-2,4-dithio- 41549-91-1
2-Butanaminium,4-oxo-N,N,N-trimethyl-4-(2-(trimethylammonio)ethoxy)-, diiodide 41549-91-1
1-Butanaminium, N,N,N-tributyl-,azidotriphenyl(thiocyanato-N)plumbate(1-) 158882-72-5
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Butane 106-97-8
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Butane, 1,4-bis(decylsulfonyl)- 73758-22-2
Butane, 1,4-bis(2,3-epoxypropoxy)- 2425-79-8
Butane, 1,1-bis(p-ethoxyphenyl)-2-nitro- 26258-71-9
Butane, 2,2-bis(ethylsulfonyl)- 76-20-0
Biuret, 1-butyl-5-phenyl-2,4-dithio- 79491-02-4
Butane, 1-bromo- 109-65-9
Butane, 2-bromo- 78-76-2
Butane, 1-bromo-4-fluoro- 462-72-6
Butane, 1-bromo-3-methyl- 107-82-4
Butane, 1-chloro- 109-69-3
Butane, 2-chloro- 78-86-4
Butane, 1-chloro-2,3-dibromo- 111712-50-6
Butane, 3-chloro-1,2-dibromo- 97166-13-7
Butane, 1-chloro-4-fluoro- 462-73-7
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1,4-Butanediamine,N-(3-(9-acridinylamino)propyl)-N'-(3-aminopropyl)- 101009-07-8
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