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MSDS  : 1,4-Butanediamine
CAS  : 110-60-1
SYNONYMS  : * Butylenediamine * 1,4-Butylenediamine * 1,4-Diaminobutane * Putrescin * Putrescine * Tetramethylenediamine * 1,4-Tetramethylenediamine
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : EJ6800000
CHEMICAL NAME : 1,4-Butanediamine
CAS REGISTRY NUMBER : 110-60-1
BEILSTEIN REFERENCE NO. : 0605282
REFERENCE : 4-04-00-01283 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 16
MOLECULAR FORMULA : C4-H12-N2
MOLECULAR WEIGHT : 88.18
WISWESSER LINE NOTATION : Z4Z
COMPOUND DESCRIPTOR : Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Butylenediamine
* 1,4-Butylenediamine
* 1,4-Diaminobutane
* Putrescin
* Putrescine
* Tetramethylenediamine
* 1,4-Tetramethylenediamine

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 463 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Sense Organs and Special Senses (Eye) - ptosis
Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0538638

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZEPTAT Zeitschrift fuer Experimentelle Pathologie und Therapie. (Berlin,
Ger.) V.1-22, 1905-21. For publisher information, see REXMAS.
Volume(issue)/page/year: 17,59,1915

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
070944) V.1- 1973- Volume(issue)/page/year: 14,111,1985

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1750 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
Vascular - BP lowering not characterized in autonomic section
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 18(6),9,1955

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
Volume(issue)/page/year: 83,481,1920

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1576 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Kidney, Ureter, Bladder - other changes in urine composition
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0538638

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZEPTAT Zeitschrift fuer Experimentelle Pathologie und Therapie. (Berlin,
Ger.) V.1-22, 1905-21. For publisher information, see REXMAS.
Volume(issue)/page/year: 17,59,1915

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
Volume(issue)/page/year: 83,481,1920

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Rectal
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
Volume(issue)/page/year: 83,481,1920

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 314 mg/kg
SEX/DURATION : female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - other effects to embryo
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 28,237,1983

** MUTATION DATA **

TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - mouse Liver
DOSE/DURATION : 2 mmol/L
REFERENCE :
AMOKAG Acta Medicia Okayama. (Okayama Univ. Medical School, Okayama, Japan)
V.27 1973- Volume(issue)/page/year: 33,149,1979

TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - mouse Ascites tumor
DOSE/DURATION : 10 mmol/L
REFERENCE :
AMOKAG Acta Medicia Okayama. (Okayama Univ. Medical School, Okayama, Japan)
V.27 1973- Volume(issue)/page/year: 33,149,1979

TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - mouse Liver
DOSE/DURATION : 20 mmol/L
REFERENCE :
AMOKAG Acta Medicia Okayama. (Okayama Univ. Medical School, Okayama, Japan)
V.27 1973- Volume(issue)/page/year: 33,149,1979

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4958
No. of Facilities: 3 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 3 (estimated)
No. of Female Employees: 3 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
2-Butanamine, N-methyl-N-2-propynyl-, hydrochloride 143347-16-4
1-Butanamine, N-nitroso-N-propyl- 25413-64-3
Butanediamine, N,N,N',N'-tetramethyl- 27195-72-8
1-Butanaminium,N-(3-(2-(butyldimethylammonio)ethoxy)-3-oxopropyl)-N,N-dimethyl-, diiodide 27195-72-8
2-Butanaminium,1-(3-(diethylmethylammonio)-3-oxopropoxy)-N,N,N-trimethyl-, diiodide 27195-72-8
Biuret, 1-butyl-2,4-dithio-1-phenyl- 27195-72-8
2-Butanaminium,N,N-dimethyl-4-(2-(dimethylethylammonio)ethoxy)-N-ethyl-4-oxo-, diiodide 27195-72-8
2-Butanaminium,N,N-dimethyl-1-(3-(dimethylethylammonio)-1-oxopropoxy)-N-ethyl-, diiodide 27195-72-8
1-Butanaminium,4-((2,6-dimethylphenyl)methylamino)-N,N,N-triethyl-,bromide 27195-72-8
2-Butanaminium,4,4'-((2,5-dioxo-1,4-cyclohexadiene-1,4-diyl)imino)bis(N,N-diethyl-N-methy l-, diiodide, (-)- 27195-72-8
2-Butanaminium,4,4'-((2,5-dioxo-1,4-cyclohexadiene-1,4-diyl)imino)bis(N,N-diethyl-N-methy l-, diiodide, (+)- 27195-72-8
2-Butanaminium,4,4'-((2,5-dioxo-1,4-cyclohexadiene-1,4-diyl)imino)bis(N,N-diethyl-N-methy l-, diiodide, (+-)- 27195-72-8
1-Butanaminium,N-ethyl-N,N-dimethyl-3-((tricyclo(3.3.1.1(sup3,7))dec-1-ylcarbonyl)oxy)-, iodide 54099-18-2
1-Butanaminium,N,N'-((9-oxo-9H-fluorene-2,7-diyl)bis(carbonyloxy-3,1-propanediyl))bis(N- butyl-N-methyl-, diiodide,hydrate 41549-91-1
2-Butanaminium,4-oxo-N,N,N,2-tetramethyl-4-(2-(trimethylammonio)ethoxy)-, diiodide 41549-91-1
2-Butanaminium,1-(1-oxo-3-(trimethylammonio)propoxy)-N,N,N-trimethyl-, diiodide 41549-91-1
Biuret, 1-(p-butylphenyl)-2,4-dithio- 41549-91-1
2-Butanaminium,4-oxo-N,N,N-trimethyl-4-(2-(trimethylammonio)ethoxy)-, diiodide 41549-91-1
1-Butanaminium, N,N,N-tributyl-,azidotriphenyl(thiocyanato-N)plumbate(1-) 158882-72-5
1-Butanaminium, N,N,N-tributyl-,dibromodiiododiphenylplumbate(2-) (2:1) 158882-74-7
Butane 106-97-8
Butane, 2,3-bis(2-chloroethylthio)- 63732-12-7
Butane, 1,1-bis(p-chlorophenyl)-2-nitro- 117-26-0
Butane, 1,4-bis(decylsulfonyl)- 73758-22-2
Butane, 1,4-bis(2,3-epoxypropoxy)- 2425-79-8
Butane, 1,1-bis(p-ethoxyphenyl)-2-nitro- 26258-71-9
Butane, 2,2-bis(ethylsulfonyl)- 76-20-0
Biuret, 1-butyl-5-phenyl-2,4-dithio- 79491-02-4
Butane, 1-bromo- 109-65-9
Butane, 2-bromo- 78-76-2
Butane, 1-bromo-4-fluoro- 462-72-6
Butane, 1-bromo-3-methyl- 107-82-4
Butane, 1-chloro- 109-69-3
Butane, 2-chloro- 78-86-4
Butane, 1-chloro-2,3-dibromo- 111712-50-6
Butane, 3-chloro-1,2-dibromo- 97166-13-7
Butane, 1-chloro-4-fluoro- 462-73-7
Butane, 1-chloro-4-fluoro-1-nitro- 63732-17-2
Bismuthine, tris((carboxymethyl)thio)- 19401-26-4
Biuret, 1-(p-chlorophenyl)-2,4-dithio- 80309-99-5
Butane, 2-chloro-2-nitro- 22236-53-9
Butanediamide,N,N'-bis(9,10-dihydro-9-oxo-1-acridinyl)- 114069-29-3
Butanediamide,N-hydroxy-N'-(4-(((((2-hydroxyethyl)amino)oxacetyl)amino)sulfonyl)phenyl)- 85877-98-1
Butanediamide,N-(3-hydroxypropyl)-N'-(4-((((oxo(2-phenylethyl)amino)acetyl)amino)sulfony l) phenyl)- 85877-95-8
1,3-Butanediamine 590-88-5
1,4-Butanediamine 110-60-1
1,1-Butanediamine,N-(9-acridinyl)-N'-(3-(9-acridinylamino)propyl)- 58478-34-5
1,4-Butanediamine,N-(3-(9-acridinylamino)propyl)-N'-(3-aminopropyl)- 101009-07-8
1,4-Butanediamine, N-(3-aminopropyl)- 124-20-9
1,4-Butanediamine, N-(3-aminopropyl)-, phosphate(2:3) 49721-50-8

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