*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : EJ9965500
CHEMICAL NAME : Butanedioic acid, esters,
mono(2-(dimethylamino)-1-((2-(2-(3-methoxyphenyl)ethy
l)phenoxy) methyl)ethyl) ester, hydrochloride, (+-)-
CAS REGISTRY NUMBER : 135159-51-2
LAST UPDATED : 199609
DATA ITEMS CITED : 12
MOLECULAR FORMULA : C24-H31-N-O6.Cl-H
MOLECULAR WEIGHT : 466.02
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Anplag
* MCI-9042
* Sarpogrelate hydrochloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4400 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 19(Suppl 3),S667,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 108 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - peritonitis
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 19(Suppl 3),S667,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >45 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 19(Suppl 3),S667,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2550 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 19(Suppl 3),S667,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 65 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - peritonitis
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 19(Suppl 3),S667,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >45 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 19(Suppl 3),S667,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : >3 gm/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 19(Suppl 3),S667,1991
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 117 gm/kg/52W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Nutritional and Gross Metabolic - changes in potassium
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 19(Suppl 3),S673,1991
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 6240 mg/kg
SEX/DURATION : female 17-21 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 19(Suppl 3),S731,1991
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 2080 mg/kg
SEX/DURATION : female 17-21 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
per # born alive)
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 19(Suppl 3),S731,1991
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 7040 mg/kg
SEX/DURATION : female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 19(Suppl 3),S707,1991
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 27 gm/kg
SEX/DURATION : male 9 week(s) pre-mating
female 2 week(s) pre-mating - 7 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
Reproductive - Maternal Effects - other effects
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 19(Suppl 3),S707,1991
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Butane, 1,4-diiodo-
| 628-21-7 |
Butane,1,3-dimethoxy-
| 10143-66-5 |
Butane, 2,3-dimethyl-
| 79-29-8 |
Butane,3-(N,N-dimethylamino)-1,1-diphenyl-1-ethylsulfonyl-,hydrochloride, (-)-
| 63732-19-4 |
Butane, 3-(N,N-dimethylamino)-1,1-diphenyl-,hydrochloride
| 22173-83-7 |
Biuret, 2,4-dithio-1-(p-ethoxyphenyl)-
| 22173-83-7 |
Butanedinitrile,((4-methoxyphenyl)methylene)methylene-, (Z)-
| 125210-89-1 |
Butanedioic acid, ((aminocarbonyl)amino)-,dihydrazide, (+-)-
| 37458-18-7 |
Butanedioic acid,(((2-amino-3-methyl-1-oxobutyl)amino)oxy)-,(R-(R*,S*))-
| 73020-27-6 |
Butanedioic acid, bis(2-(diethylamino)-1-phenylethyl)ester
| 73020-27-6 |
Butanedioic acid,2,3-bis((dimethoxyphosphinothioyl)thio)-, diethylester
| 32358-09-1 |
Butanedioic acid,bis(2-(dimethylamino)-1-phenylethyl) ester
| 32358-09-1 |
Butanedioic acid, bis((5-fluoro-3-pyridinyl)methylester
| 23649-13-0 |
Butanedioic acid,bis(2-(1-pyrrolidinyl)-1-phenylethyl) ester
| 23649-13-0 |
Butanedioic acid, (1-benzoyl-2,2-dimethylhydrazino)-,dimethyl ester
| 96804-16-9 |
Butanedioic acid, compd. with4-(2-chloro-10,11-dihydrodibenzo(b,f)thiepin-10-yl)-1- piperazineethanol
| 60003-04-5 |
Biuret, 2,4-dithio-5-ethyl-1-phenyl-1-propyl-
| 60003-04-5 |
Butanedioic acid, compd. with7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one (1:2)
| 36434-10-3 |
Butanedioic acid, compd. with8-chloro-5-methyl-11-(4-methyl-1-piperazinyl)-5H-pyrrolo(1,2-b) (1,2,5)benzotriazepine (1:1)
| 102636-45-3 |
Butanedioic acid,6-chloro-2-methyl-3-((2-pyridinylamino)carbonyl)-2H-thieno(2,3-e)-1,2- thiazin-4-yl methyl ester,S,S-dioxide
| 123252-98-2 |
Butanedioic acid, (4-chlorophenoxy)-,bis(2-(dimethylamino)ethyl) ester, ethanedioate (1:2)
| 129320-22-5 |
Butanedioic acid,((6-chloro-3-pyridazinyl)hydrazono)-, dimethyl ester
| 69579-24-4 |
Butanedioic acid, ((diethoxyphosphinothioyl)thio)-,bis((methylthio)methyl) ester
| 32744-43-7 |
Butanedioic acid, 2,3-dihydroxy-, (R-(R*,R*)),bismuth(3+) potassium salt (1:1:1)
| 5798-41-4 |
Butanedioic acid, 2,3-dihydroxy-, (R-(R*,R*))-,tin(2+) salt (1:1)
| 815-85-0 |
Butanedioic acid, 2,3-dimercapto-,mono(3-methylbutyl) ester, (R*,S*)-
| 142609-62-9 |
Butanedioic acid, ((dimethoxyphosphinothioyl)thio)-,diethyl ester, mixt. with O,O-bis(1- methylethyl)S-(phenylmethyl)phosphorothioate
| 61104-03-8 |
Biuret, 2,4-dithio-1-(p-(ethylsulfonyl)phenyl)-
| 61104-03-8 |
Butanedioic acid, compd. with3-(2-(dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide (1:1)
| 103628-48-4 |
Butanedioic acid,(2,2-dimethyl-1-((methylamino)carbonyl)hydrazino)-,dimethyl ester
| 96804-13-6 |
Butanedioic acid,(2,2-dimethyl-1-((phenylamino)carbonyl)hydrazino)-,dimethyl ester
| 96804-14-7 |
Butanedioic acid, compd. withN,N-dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)ethanamine (1:1),mixt. with2-(diethylamino)ethyl(1,1'-bicyclohexyl)-1-carboxylate hydrochloride and 5-hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride
| 8064-77-5 |
Butanedioic acid, compd. withN,N-dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)ethanamine (1:1),mixt. with5-hydroxy-6-methyl-3,4-pyridinedimethanolhydrochloride
| 99007-20-2 |
Butanedioic acid, compd. with2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole(1:1)
| 100678-32-8 |
Butanedioic acid, 4'''-ester with5-((O-2,6-dideoxy-3-O-methyl-alpha-L-lyxo-hexopyranosyl-(1-4)-O-2,3,6-trideoxy-3-C-methyl-3-nitro-beta-L-ribo-hexopyranosyl-(1-4)- 2,3,6-trideoxy-3-C-methyl-3-nitro-beta-L-ribo-hexopyranosyl)oxy)-4-(dimethylamino)-3,4,5,6, 11,12,13,14-octahydro-3,10,13,15-tetrahydroxy-6,13-dimethyl-11-((2,3,6-trideoxy-3-(dim ethylamino)-alpha-L-lyxo-hexopyranosyl)oxy)-2,6-epoxy-2H-naphthaceno(1,2-b)oxocin-9,16-dione, dihydrochloride
| 100678-32-8 |
Butanedioic acid, esters,mono(2-(dimethylamino)-1-((2-(2-(3-methoxyphenyl)ethyl)phenoxy) methyl)ethyl) ester, hydrochloride, (+-)-
| 135159-51-2 |
Butanedioic acid, (ethoxymethylene)oxo-, diethylester
| 52942-64-0 |
Butanedioic acid, hydroxy-, dibutyl ester, (+-)-
| 6280-99-5 |
Biuret, 2,4-dithio-1-(4-isoquinolyl)-
| 6280-99-5 |
Butanedioic acid, hydroxy-, lead(2+) salt (11)
| 816-68-2 |
Butanedioic acid, 2-hydroxy-2-(phenylmethyl)-
| 90326-97-9 |
Butanedioic acid, hydroxy-, 4-(phenylmethyl) ester,(S)-
| 66178-06-1 |
Butanedioic acid, methylene-, homopolymer
| 25119-64-6 |
Butanedioic acid, methylene-, polymer with2-propenoic acid
| 25948-33-8 |
Butanedioic acid,mono(1-((4-(aminocarbonyl)-1-piperidinyl)methyl)-2-(2-(2- phenylethyl)phenoxy)ethyl) ester,monohydrochloride
| 86819-30-9 |
Butanedioic acid,mono(2-((4,6-bis(dimethylamino)-1,3,5-triazin-2-yl)methylamino)ethyl) ester
| 64124-18-1 |
Butanedioic acid,mono((6-(3-(3-carboxy-1-oxopropoxy)-3,4-dihydro-5,7-dihydroxy-4-oxo-2H-1-benzopyran-2-yl)-2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-1,4-benzodioxin -2-yl)methyl) ester, disodiumsalt, (2R-(2-alpha,3-beta,6(2R*,3R*)))-
| 55254-34-7 |
Butanedioic acid,mono(7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl) ester, monosodium salt, (-)-
| 34332-52-0 |
Butanedioic acid,mono(7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl) ester, monosodium salt, (+)-
| 34332-53-1 |
Bismuthine, tris((carboxymethyl)thio)-, trisodiumsalt
| 150-49-2 |
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