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MSDS  : Acetic acid, lead salt
CAS  : 15347-57-6
SYNONYMS  : * Lead acetate
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : AI5200000
CHEMICAL NAME : Acetic acid, lead salt
CAS REGISTRY NUMBER : 15347-57-6
LAST UPDATED : 199509
DATA ITEMS CITED : 18
MOLECULAR FORMULA : C2-H4-O2.xPb
MOLECULAR WEIGHT : 1510.39
COMPOUND DESCRIPTOR : Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Lead acetate

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 286 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
5,91,1983

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 399 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068
Warsaw 1, Poland) V.1- 1950- Volume(issue)/page/year: 26,425,1975

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 13 gm/kg/13W-I
TOXIC EFFECTS :
Spinal Cord - other degenerative changes
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
19,380,1992

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 7 gm/kg/10W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other Enzymes
Biochemical - Metabolism (Intermediary) - porphyrin including bile pigments
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 14,84,1984

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 348 mg/kg/8W-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - recording from peripheral motor nerve
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
07094) V.1- 1966- Volume(issue)/page/year: 37,47,1986

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 60 mg/kg/30D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Endocrine - changes in adrenal weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other Enzymes
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
07094) V.1- 1966- Volume(issue)/page/year: 37,62,1986

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 42 mg/kg/10W-I
TOXIC EFFECTS :
Blood - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other Enzymes
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
43,59,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 1250 mg/kg/25D-I
TOXIC EFFECTS :
Endocrine - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
MTPEEI Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and
Ecology. (Mezhdunarodnaya Kniga, ul.B. Yakimanka, 39 117049 Moscow, Russia)
No.1- 1993- Volume(issue)/page/year: (9-10),6,1993

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 18900 ug/kg
SEX/DURATION : male 9 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
REFERENCE :
ANDRDQ Andrologia. (Grosse Verlag GmbH, Kurfuerstenstr. 112-113, D-1000
Berlin 30, Fed. Rep. Ger.) V.6- 1974- Volume(issue)/page/year:
21,161,1989

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 4400 mg/kg
SEX/DURATION : lactating female 22 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
109(3),482,1991

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 50 mg/kg
SEX/DURATION : female 18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
BNEOBV Biology of the Neonate. (S. Karger Pub., Inc., 79 Fifth Ave., New
York, NY 10003) V.15- 1970- Volume(issue)/page/year: 58,41,1990

** MUTATION DATA **

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 100 ug/L
REFERENCE :
CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San
Francisco, CA 94103) V.1- 1929- Volume(issue)/page/year: 53,263,1988

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 1 umol/L
REFERENCE :
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science
Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-
Volume(issue)/page/year: 8,39,1984

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Leukocyte
DOSE/DURATION : 10 umol/L
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.1- 1945- Volume(issue)/page/year: 30,1006,1974

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo

EPA GENETOX PROGRAM 1988, Positive: Sperm morphology-mouse F1; Sperm
morphology-mouse

EPA GENETOX PROGRAM 1988, Positive/dose response: Cell transform.-BALB/c-3T3

EPA GENETOX PROGRAM 1988, Negative: In vitro SCE-human lymphocytes; In vitro
SCE-human


*** END OF RECORD ***
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NAMECAS
Acetic acid,(6-isopropyl-2-methoxycarbonyl-3-methylphenoxy)-,2-(diethylamino)ethyl ester 52073-15-1
Acetic acid,(6-isopropyl-2-methoxycarbonyl-3-methylphenoxy)-,2-(dimethylamino)ethyl ester 52073-09-3
Acetic acid,(6-isopropyl-2-methoxycarbonyl-3-methylphenoxy)-,(2-dimethylamino-1-methyl ethyl) ester 53206-86-3
Acetic acid,(6-isopropyl-2-methoxycarbonyl-3-methylphenoxy)-,3-(dimethylamino)propyl ester 53206-87-4
Acetic acid,(6-isopropyl-2-methoxycarbonyl-3-methylphenoxy)-,2-morpholinoethyl ester 52073-17-3
Acetic acid,(3-ethyl-5-((2-hydroxyethyl)methylamino)-4-oxo-5-phenyl-2-thiazolidinylide ne)-, ethyl ester 58906-56-2
Acetic acid,(6-isopropyl-2-methoxycarbonyl-3-methylphenoxy)-,2-piperidinoethyl ester 52073-11-7
Acetic acid, 3-isopropyl-5-methoxyphenyl- 51028-84-3
Acetic acid, 2-isopropyl-5-methyl-2-hexen-1-yl ester 40853-56-3
Acetic acid,2-(o-(((4-isopropyl-2-methyl-5-oxo-1-phenyl-3-pyrazolin-3-yl)methyl)carbam oyl) phenyl)- 74512-62-2
Acetic acid, (isopropylnitrosoamino)methyl ester 70715-91-2
Acetic acid, isothiocyanato-, ethyl ester 24066-82-8
Acetic acid, lanthanum(3+) salt 917-70-4
Acetic acid, lead salt 15347-57-6
Acetic acid, lead(2+) salt 301-04-2
Acetic acid, lead(4+) salt 546-67-8
Acetic acid, (ethylenedinitrilo)tetra-, disodiumsalt, dihydrate 6381-92-6
Acetic acid,2-(6-(ethyl(2-hydroxypropyl)amino)-3-pyridazinyl)hydrazide 65919-92-8
Acetic acid, lithium salt 546-89-4
Acetic acid, magnesium salt 142-72-3
Acetic acid, manganese(II) salt (21) 638-38-0
Acetic acid, manganese(2+) salt, tetrahydrate 6156-78-1
Acetic acid, p-menth-3-yl ester, dl- 16409-45-3
Acetic acid, p-menth-3-yl ester, l- 2623-23-6
Acetic acid, mercapto- 68-11-1
Acetic acid, mercapto-,p-carbamoyldithiobenzenearsonite (2:1) 531-72-6
Acetic acid, mercapto-,p-carbamoyldithiobenzenearsonite (2:1), disodium salt 14433-82-0
Acetic acid, mercapto-, 2-chloroethyl ester 63906-38-7
Acetic acid, 2-(alpha-ethyl-p-methoxybenzyl)hydrazide 63906-38-7
Acetic acid, mercapto-,(1-(2-chlorophenyl)ethylidene)hydrazide, (E)- 133662-03-0
Acetic acid, mercapto-,((2-chlorophenyl)methylene)hydrazide, (E)- 133662-05-2
Acetic acid, mercapto-, diester withdithio-p-ureidobenzenearsonous acid 120-02-5
Acetic acid, 2-(2-mercaptoethyl)amino-, hydrochloride 6940-79-0
Acetic acid, mercapto-, ethylene ester 123-81-9
Acetic acid, mercapto-, ethyl ester 623-51-8
Acetic acid, mercapto-, ethyl ester, S-ester withO,O-diethyl phosphorodithioate 919-54-0
Acetic acid, mercapto-, ethyl ester, S-ester withO,O-diethyl phosphorothioate 2425-25-4
Acetic acid, mercapto-, ethyl ester, S-ester withO,O-dimethylphosphorodithioate 1068-13-9
Acetic acid, mercapto-, ethyl ester, S-ester withO,O-dimethyl phosphorothioate 2088-72-4
Acetic acid,((2-ethyl-3-methyl-4-oxo-4H-1-benzopyran-7-yl)oxy)-,ethyl ester 102585-54-6
Acetic acid, mercapto-, ethyl ester, propylmethylphosphonotrithioate 63906-39-8
Acetic acid, mercapto-, 2-ethylhexyl ester 7659-86-1
Acetic acid, 2-((2-mercaptoethyl)thio)-, ethyl ester,S-ester with O,O-diethyl phosphoro dithioate 63233-95-4
Acetic acid, 2-((2-mercaptoethyl)thio)-, isopropyleseter, S-ester with O,O- diethyl phosphorodithioate 63233-96-5
Acetic acid, 2-((2-mercaptoethyl)thio)-, methylester, S-ester with O,O-diethyl phosphoro dithioate 63233-94-3
Acetic acid, 2-((2-mercaptoethyl)thio)-, methylester, S-ester with diethyl phosphorothioate 63233-97-6
Acetic acid, mercapto-, isooctyl ester 25103-09-7
Acetic acid, 2-mercapto-, isopropyl ester, S-esterwith ethyl methylphosphonothioate 25103-09-7
Acetic acid, mercapto-, methyl ester 2365-48-2
Acetic acid, mercapto-, methyl ester, S-ester withO,O-diethyl phosphorodithioate 919-53-9

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