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MSDS  : Acetic acid, mercapto-
CAS  : 68-11-1
SYNONYMS  : * Acide thioglycolique * Glycolic acid, thio- * Glycolic acid, 2-thio- * Kyselina merkaptooctova * Kyselina thioglykolova * Mercaptoacetate * Mercaptoacetic acid * alpha-Mercaptoacetic acid * 2-Mercaptoacetic acid * Thioglycolic acid * 2-Thioglycolic acid * Thioglycolic acid * Thioglycollic acid * Thiovanic acid * USAF CB-35
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : AI5950000
CHEMICAL NAME : Acetic acid, mercapto-
CAS REGISTRY NUMBER : 68-11-1
BEILSTEIN REFERENCE NO. : 0506166
REFERENCE : 4-03-00-00600 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 32
MOLECULAR FORMULA : C2-H4-O2-S
MOLECULAR WEIGHT : 92.12
WISWESSER LINE NOTATION : SH1VQ
COMPOUND DESCRIPTOR : Agricultural Chemical
Primary Irritant
SYNONYMS/TRADE NAMES :
* Acide thioglycolique
* Glycolic acid, thio-
* Glycolic acid, 2-thio-
* Kyselina merkaptooctova
* Kyselina thioglykolova
* Mercaptoacetate
* Mercaptoacetic acid
* alpha-Mercaptoacetic acid
* 2-Mercaptoacetic acid
* Thioglycolic acid
* 2-Thioglycolic acid
* Thioglycolic acid
* Thioglycollic acid
* Thiovanic acid
* USAF CB-35

*** HEALTH HAZARD DATA ***

** SKIN/EYE IRRITATION DATA **

TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Human
DOSE/DURATION : 3%
REFERENCE :
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For publisher
information, see IOHSA5. Volume(issue)/page/year: 15,669,1946

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 114 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB
Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
Rep.) V.1- 1955- Volume(issue)/page/year: 20,575,1974

TYPE OF TEST : LC - Lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >620 ppm/7H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure
Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 6,1541,1991

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 70 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB
Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
Rep.) V.1- 1955- Volume(issue)/page/year: 20,575,1974

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 242 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB
Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
Rep.) V.1- 1955- Volume(issue)/page/year: 20,575,1974

TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 7 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,111,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 47 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series
C: Medicine. (Tohoku University, Research Institute for Tuberculosis and
Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-
Volume(issue)/page/year: 36(1-4),10,1989

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 138 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 31,1713,1981

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 145 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year:
60,278,1964

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 119 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB
Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
Rep.) V.1- 1955- Volume(issue)/page/year: 20,575,1974

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 300 mg/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 13(1),48,1969

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce
Way, Colchester, Essex CO2 8HP, UK) V.1- 1906- Volume(issue)/page/year:
41,325,1947

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 126 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,586,1969

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 157 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB
Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
Rep.) V.1- 1955- Volume(issue)/page/year: 20,575,1974

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 39(4),86,1974

*** REVIEWS ***

ACGIH TLV-TWA 3.8 mg/m3 (1 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-AUSTRALIA:TWA 1 ppm (4 mg/m3) JAN 1993

OEL-BELGIUM:TWA 1 ppm (3.8 mg/m3) JAN 1993

OEL-DENMARK:TWA 1 ppm (5 mg/m3) JAN 1993

OEL-FINLAND:TWA 1 ppm (5 mg/m3);STEL 3 ppm (15 mg/m3) JAN 1993

OEL-FRANCE:TWA 1 ppm (5 mg/m3);Skin JAN 1993

OEL-HUNGARY:TWA 0.5 mg/m3;STEL 1 mg/m3 JAN 1993

OEL-RUSSIA:STEL 0.1 mg/m3;Skin JAN 1993

OEL-SWITZERLAND:TWA 1 ppm (4 mg/m3);Skin JAN 1993

OEL-UNITED KINGDOM:TWA 1 ppm (3.8 mg/m3);Skin JAN 1993

OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV

OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO THIOGLYCOLIC ACID-air:10H TWA 1 ppm (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83835
No. of Facilities: 5167 (estimated)
No. of Industries: 10
No. of Occupations: 9
No. of Employees: 35238 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83835
No. of Facilities: 2428 (estimated)
No. of Industries: 10
No. of Occupations: 12
No. of Employees: 30055 (estimated)
No. of Female Employees: 15141 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Acetic acid,(6-isopropyl-2-methoxycarbonyl-3-methylphenoxy)-,2-(diethylamino)ethyl ester 52073-15-1
Acetic acid,(6-isopropyl-2-methoxycarbonyl-3-methylphenoxy)-,2-(dimethylamino)ethyl ester 52073-09-3
Acetic acid,(6-isopropyl-2-methoxycarbonyl-3-methylphenoxy)-,(2-dimethylamino-1-methyl ethyl) ester 53206-86-3
Acetic acid,(6-isopropyl-2-methoxycarbonyl-3-methylphenoxy)-,3-(dimethylamino)propyl ester 53206-87-4
Acetic acid,(6-isopropyl-2-methoxycarbonyl-3-methylphenoxy)-,2-morpholinoethyl ester 52073-17-3
Acetic acid,(3-ethyl-5-((2-hydroxyethyl)methylamino)-4-oxo-5-phenyl-2-thiazolidinylide ne)-, ethyl ester 58906-56-2
Acetic acid,(6-isopropyl-2-methoxycarbonyl-3-methylphenoxy)-,2-piperidinoethyl ester 52073-11-7
Acetic acid, 3-isopropyl-5-methoxyphenyl- 51028-84-3
Acetic acid, 2-isopropyl-5-methyl-2-hexen-1-yl ester 40853-56-3
Acetic acid,2-(o-(((4-isopropyl-2-methyl-5-oxo-1-phenyl-3-pyrazolin-3-yl)methyl)carbam oyl) phenyl)- 74512-62-2
Acetic acid, (isopropylnitrosoamino)methyl ester 70715-91-2
Acetic acid, isothiocyanato-, ethyl ester 24066-82-8
Acetic acid, lanthanum(3+) salt 917-70-4
Acetic acid, lead salt 15347-57-6
Acetic acid, lead(2+) salt 301-04-2
Acetic acid, lead(4+) salt 546-67-8
Acetic acid, (ethylenedinitrilo)tetra-, disodiumsalt, dihydrate 6381-92-6
Acetic acid,2-(6-(ethyl(2-hydroxypropyl)amino)-3-pyridazinyl)hydrazide 65919-92-8
Acetic acid, lithium salt 546-89-4
Acetic acid, magnesium salt 142-72-3
Acetic acid, manganese(II) salt (21) 638-38-0
Acetic acid, manganese(2+) salt, tetrahydrate 6156-78-1
Acetic acid, p-menth-3-yl ester, dl- 16409-45-3
Acetic acid, p-menth-3-yl ester, l- 2623-23-6
Acetic acid, mercapto- 68-11-1
Acetic acid, mercapto-,p-carbamoyldithiobenzenearsonite (2:1) 531-72-6
Acetic acid, mercapto-,p-carbamoyldithiobenzenearsonite (2:1), disodium salt 14433-82-0
Acetic acid, mercapto-, 2-chloroethyl ester 63906-38-7
Acetic acid, 2-(alpha-ethyl-p-methoxybenzyl)hydrazide 63906-38-7
Acetic acid, mercapto-,(1-(2-chlorophenyl)ethylidene)hydrazide, (E)- 133662-03-0
Acetic acid, mercapto-,((2-chlorophenyl)methylene)hydrazide, (E)- 133662-05-2
Acetic acid, mercapto-, diester withdithio-p-ureidobenzenearsonous acid 120-02-5
Acetic acid, 2-(2-mercaptoethyl)amino-, hydrochloride 6940-79-0
Acetic acid, mercapto-, ethylene ester 123-81-9
Acetic acid, mercapto-, ethyl ester 623-51-8
Acetic acid, mercapto-, ethyl ester, S-ester withO,O-diethyl phosphorodithioate 919-54-0
Acetic acid, mercapto-, ethyl ester, S-ester withO,O-diethyl phosphorothioate 2425-25-4
Acetic acid, mercapto-, ethyl ester, S-ester withO,O-dimethylphosphorodithioate 1068-13-9
Acetic acid, mercapto-, ethyl ester, S-ester withO,O-dimethyl phosphorothioate 2088-72-4
Acetic acid,((2-ethyl-3-methyl-4-oxo-4H-1-benzopyran-7-yl)oxy)-,ethyl ester 102585-54-6
Acetic acid, mercapto-, ethyl ester, propylmethylphosphonotrithioate 63906-39-8
Acetic acid, mercapto-, 2-ethylhexyl ester 7659-86-1
Acetic acid, 2-((2-mercaptoethyl)thio)-, ethyl ester,S-ester with O,O-diethyl phosphoro dithioate 63233-95-4
Acetic acid, 2-((2-mercaptoethyl)thio)-, isopropyleseter, S-ester with O,O- diethyl phosphorodithioate 63233-96-5
Acetic acid, 2-((2-mercaptoethyl)thio)-, methylester, S-ester with O,O-diethyl phosphoro dithioate 63233-94-3
Acetic acid, 2-((2-mercaptoethyl)thio)-, methylester, S-ester with diethyl phosphorothioate 63233-97-6
Acetic acid, mercapto-, isooctyl ester 25103-09-7
Acetic acid, 2-mercapto-, isopropyl ester, S-esterwith ethyl methylphosphonothioate 25103-09-7
Acetic acid, mercapto-, methyl ester 2365-48-2
Acetic acid, mercapto-, methyl ester, S-ester withO,O-diethyl phosphorodithioate 919-53-9

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