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MSDS  : Coumarin, 3-chloro-7-hydroxy-4-methyl-, O-ester with O,O-diethyl phosphorothioate
CAS  : 56-72-4
SYNONYMS  : * Agridip * Asunthol * Asuntol * Azunthol * BAY 21/199 * Bayer 21/199 * Baymix * Baymix 50 * 3-Chloro-7-hydroxy-4-methyl-coumarin O,O-diethyl phosphorothioate * 3-Chloro-7-hydroxy-4-methyl-coumarin O-ester with O,O-diethyl phosphorothioate * 3-Chloro-4-methyl-7-coumarinyl diethyl phosphorothioate * O-3-Chloro-4-methyl-7-coumarinyl O,O-diethyl phosphorothioate * 3-Chloro-4-methyl-7-hydroxycoumarin diethyl thiophosphoric acid ester * 3-Chloro-4-methylumbelliferone O-ester with O,O-diethyl phosphorothioate * CO-Ral * Coumafos * Coumaphos * Cumafos * O,O-Diaethyl-O-(3-chlor-4-methyl-cumarin-7-yl)-monothiophosphat * O,O-Diethyl-O-(3-chloor-4-methyl-cumarin-7-yl)monothiofosfaat * O,O-Diethyl O-(3-chloro-4-methyl-7-coumarinyl)phosphorothioate * O,O-Diethyl O-(3-chloro-4-methylcoumarinyl-7) thiophosphate * O,O-Diethyl O-(3-chloro-4-methyl-2-oxo-2H-benzopyran-7-yl)phosphorothioate * O,O-Diethyl 3-chloro-4-methyl-7-umbelliferone thiophosphate * O,O-Diethyl O-(3-chloro-4-methylumbelliferyl)phosphorothioate * Diethyl 3-chloro-4-methylumbelliferyl thionophosphate * Diethyl thiophosphoric acid ester of 3-chloro-4-methyl-7-hydroxycoumarin * O,O-Dietil-O-(3-cloro-4-metil-cumarin-7-il-monotiofosfato) * Diolice * ENT 17,957 * Meldane * Meldone * Muscatox * NCI-C08662 * Negashunt * Phosphorothioic acid, O,O-diethyl ester, O-ester with 3-chloro-7-hydroxy-4-methylcoumarin * Resistox * Resitox * Suntol * Thiophosphate de O,O-diethyle et de O-(3-chloro-4-methyl-7-coumarinyle) * Umbethion
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : GN6300000
CHEMICAL NAME : Coumarin, 3-chloro-7-hydroxy-4-methyl-, O-ester with
O,O-diethyl phosphorothioate
CAS REGISTRY NUMBER : 56-72-4
BEILSTEIN REFERENCE NO. : 0327083
REFERENCE : 4-18-00-00344 (Beilstein Handbook Reference)
LAST UPDATED : 199701
DATA ITEMS CITED : 28
MOLECULAR FORMULA : C14-H16-Cl-O5-P-S
MOLECULAR WEIGHT : 362.78
WISWESSER LINE NOTATION : T66 BOVJ DG E1 IOPS&O2&O2
COMPOUND DESCRIPTOR : Agricultural Chemical
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Agridip
* Asunthol
* Asuntol
* Azunthol
* BAY 21/199
* Bayer 21/199
* Baymix
* Baymix 50
* 3-Chloro-7-hydroxy-4-methyl-coumarin O,O-diethyl phosphorothioate
* 3-Chloro-7-hydroxy-4-methyl-coumarin O-ester with O,O-diethyl
phosphorothioate
* 3-Chloro-4-methyl-7-coumarinyl diethyl phosphorothioate
* O-3-Chloro-4-methyl-7-coumarinyl O,O-diethyl phosphorothioate
* 3-Chloro-4-methyl-7-hydroxycoumarin diethyl thiophosphoric acid ester
* 3-Chloro-4-methylumbelliferone O-ester with O,O-diethyl phosphorothioate
* CO-Ral
* Coumafos
* Coumaphos
* Cumafos
* O,O-Diaethyl-O-(3-chlor-4-methyl-cumarin-7-yl)-monothiophosphat
* O,O-Diethyl-O-(3-chloor-4-methyl-cumarin-7-yl)monothiofosfaat
* O,O-Diethyl O-(3-chloro-4-methyl-7-coumarinyl)phosphorothioate
* O,O-Diethyl O-(3-chloro-4-methylcoumarinyl-7) thiophosphate
* O,O-Diethyl
O-(3-chloro-4-methyl-2-oxo-2H-benzopyran-7-yl)phosphorothioate
* O,O-Diethyl 3-chloro-4-methyl-7-umbelliferone thiophosphate
* O,O-Diethyl O-(3-chloro-4-methylumbelliferyl)phosphorothioate
* Diethyl 3-chloro-4-methylumbelliferyl thionophosphate
* Diethyl thiophosphoric acid ester of 3-chloro-4-methyl-7-hydroxycoumarin
* O,O-Dietil-O-(3-cloro-4-metil-cumarin-7-il-monotiofosfato)
* Diolice
* ENT 17,957
* Meldane
* Meldone
* Muscatox
* NCI-C08662
* Negashunt
* Phosphorothioic acid, O,O-diethyl ester, O-ester with
3-chloro-7-hydroxy-4-methylcoumarin
* Resistox
* Resitox
* Suntol
* Thiophosphate de O,O-diethyle et de O-(3-chloro-4-methyl-7-coumarinyle)
* Umbethion

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 13 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept.,
Midland, MI 48640) V.1- 1945- Volume(issue)/page/year: 35,25,1979

TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 303 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and
Comparative Toxicology, Publication Office, Comparative Toxicology,
Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 24,87,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 860 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71.
Discontinued. Volume(issue)/page/year: 9,119,1970

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 7500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 129,699,1968

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 28 mg/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
33(10-12),334,1968

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.1- 1953- Volume(issue)/page/year: 11,91,1963

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 80 mg/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
33(10-12),334,1968

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and
Comparative Toxicology, Publication Office, Comparative Toxicology,
Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 24,87,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2600 ug/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
Volume(issue)/page/year: 53,512,1962

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 58 mg/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
33(10-12),334,1968

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 140 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,282,1966

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - pigeon
DOSE/DURATION : 5620 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing
Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
Volume(issue)/page/year: (680),157,1979

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - quail
DOSE/DURATION : 13300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing
Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
Volume(issue)/page/year: (680),157,1979

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - duck
DOSE/DURATION : 29800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept.,
Midland, MI 48640) V.1- 1945- Volume(issue)/page/year: 35,25,1979

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - domestic
DOSE/DURATION : 22600 ug/kg
TOXIC EFFECTS :
Behavioral - ataxia
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - other changes
REFERENCE :
AJVRAH American Journal of Veterinary Research. (American Veterinary
Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.1- 1940-
Volume(issue)/page/year: 41,1857,1980

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 55 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag
New York, Inc., 1971 Volume(issue)/page/year: -,341,1971

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - wild bird species
DOSE/DURATION : 1780 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing
Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
Volume(issue)/page/year: (680),157,1979

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Bird - wild bird species
DOSE/DURATION : 7500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
26,154,1973

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 168 mg/kg/28W-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
33(10-12),334,1968

** MUTATION DATA **

TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - rat Embryo
DOSE/DURATION : 1400 ng/plate
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
Volume(issue)/page/year: 1,190,1981

*** REVIEWS ***

TOXICOLOGY REVIEW
AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25,
1969-75(?). Discontinued. Volume(issue)/page/year: #73-19,1973

TOXICOLOGY REVIEW
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year:
46,1,1973

TOXICOLOGY REVIEW
PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52
Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year:
10,85,1974

TOXICOLOGY REVIEW
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year:
63,1,1976

*** U.S. STANDARDS AND REGULATIONS ***

EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat

On EPA IRIS database

NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-96,79


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Coumarin, 3-amino-4-diethylamino- 101468-13-7
Coumarin, 3-amino-4-dipropylamino- 69405-47-6
Coumarin, 6-amino-, hydrochloride 63989-79-7
Coumarin, 7-amino-4-hydroxy-3-sulfanilamido-,monosodium salt 13711-97-2
Coumarin, 3-amino-4-methylamino- 59288-10-7
Coumarin, 3-amino-4-(4-methyl-1-piperazinyl)- 59288-17-4
Coumarin, 3-amino-4-morpholino- 59288-16-3
Clinoptilolite 12173-10-3
Coumarin, 6-amino-3-(morpholinocarbonyl)- 18144-57-5
Coumarin, 4-amino-3-nitro- 38464-21-0
Coumarin, 3-amino-4-(4-phenyl-1-piperazinyl)- 69405-48-7
Coumarin, 3-amino-4-piperidino- 38464-24-3
Coumarin, 6-amino-3-(piperidinocarbonyl)- 18144-56-4
Coumarin, 6-amino-3-((piperidinocarbonyl)methyl)- 18144-59-7
Coumarin, 6-amino-3-(4-pyridyl)- 3390-71-4
Coumarin, 3-amino-4-(1-pyrrolidinyl)- 59288-15-2
Coumarin, 6-amino-3-(1-pyrrolidinylcarbonyl)- 18144-55-3
Coumarin, 6-amino-3-((1-pyrrolidinylcarbonyl)methyl)- 18144-58-6
Citric acid, trisodium salt, compd. with potassiumcitrate and citric acid, (2:2:1) 55049-48-4
Clinoptilolite (AlNaH16(SiO4)5.4H2O) 67240-23-7
Coumarin, 4-anilino-3-nitro- 50527-30-5
Coumarin, 3-benzoyl- 1846-74-8
Coumarin, 3-(2-benzoylethyl)-4-hydroxy- 6431-16-9
Coumarin, 4-benzylamino-3-nitro- 50527-29-2
Coumarin,3-(3-(4-biphenylyl)-1,2,3,4-tetrahydro-1-naphthyl)-4-hydroxy- 56073-07-5
Coumarin,8-((bis(2-hydroxyethyl)amino)methyl)-6,7-dihydroxy-4-methyl-, hydrochloride 1039-82-3
Coumarin, 5,7-bis(2-morpholinoethoxy)-4-methyl-,hydrochloride 1039-82-3
Coumarin,3-(3-(4'-bromo-1,1'-biphenyl-4-yl)-3-hydroxy-1-phenylpropyl)-4-hydroxy- 28772-56-7
Coumarin,3-(3-(4'-bromo-1,1'-biphenyl-4-yl)-1,2,3,4-tetrahydro-1-naphthyl)-4-hydrox y- 56073-10-0
Coumarin,6-bromo-4-hydroxy-3-((m-hydroxyphenyl)carbamoyl)- 19225-15-1
Clinoptilolite (Na(AlSi5O12).xH2O) 12271-42-0
Coumarin, 6-bromo-3-(2-pyridyl)- 958-58-7
Coumarin, 6-bromo-3-(4-pyridyl)- 67210-65-5
Coumarin, 3-butyl- 66898-41-7
Coumarin, 4-butylamino-3-nitro- 50527-27-0
Coumarin, 8-tert-butyl-4,6-dimethyl- 17874-34-9
Coumarin, 6-chloro- 2051-59-4
Coumarin, 3,3'-(o-chlorobenzylidene)bis(4-hydroxy- 4322-58-1
Coumarin, 3,3'-(p-chlorobenzylidene)bis(4-hydroxy- 4322-59-2
Coumarin, 3-(p-chloro-alpha-ethylbenzyl)-4-hydroxy- 2728-02-1
Coumarin, 3-chloro-7-hydroxy-4-methyl-,bis(4-chlorobutyl)phosphate 14745-61-0
Clitoria ternatea Linn., extractSUBSTANCE DEFINITION :Plant belonging to the family FabaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- 14745-61-0
Coumarin, 3-chloro-7-hydroxy-4-methyl-,bis(2-chloroethyl) phosphate 321-55-1
Coumarin, 3-chloro-7-hydroxy-4-methyl-,bis(2-chloropropyl)phosphate 4482-85-3
Coumarin, 3-chloro-7-hydroxy-4-methyl-,bis(3-chloropropyl) phosphate 4467-21-4
Coumarin, 3-chloro-7-hydroxy-4-methyl-,bis(2,3-dichloropropyl)phosphate 14663-70-8
Coumarin, 3-chloro-7-hydroxy-4-methyl-, dibutylphosphate 14663-66-2
Coumarin, 3-chloro-7-hydroxy-4-methyl-, diethylphosphate 321-54-0
Coumarin, 3-chloro-7-hydroxy-4-methyl-, dipropylphosphate 14663-67-3
Coumarin, 3-chloro-7-hydroxy-4-methyl-, O-ester withO,O-diethyl phosphorothioate 56-72-4

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