*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : GP3150000
CHEMICAL NAME : m-Cresol, 4,4'-thiobis(6-tert-butyl-
CAS REGISTRY NUMBER : 96-69-5
BEILSTEIN REFERENCE NO. : 1147776
REFERENCE : 4-06-00-06043 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 30
MOLECULAR FORMULA : C22-H30-O2-S
MOLECULAR WEIGHT : 358.58
WISWESSER LINE NOTATION : 1X1&1&R BQ D1 ESR DQ B1 EX1&1&1
COMPOUND DESCRIPTOR : Tumorigen
SYNONYMS/TRADE NAMES :
* Antage Crystal
* Antioxidant AO
* Antioxidant TMB 6
* AO 4
* Bis(3-tert-butyl-4-hydroxy-6-methylphenyl) sulfide
* Bis(4-hydroxy-5-tert-butyl-2-methylphenyl) sulfide
* Disperse MB-61
* Nocrac 300
* Nonflex BPS
* Phenol, 4,4'-thiobis(2-(1,1-dimethylethyl)-5-methyl-
* Santonox
* Santonox BM
* Santonox R
* Santowhite crystals
* Santox
* Sumilizer WX
* Sumilizer WX-R
* Thioalkofen BM 4
* Thioalkofen BMCH
* Thioalkofen MBCH
* Thioalkophene BM-4
* 4,4'-Thiobis(6-tert-butyl-m-cresol)
* 4,4'-Thiobis(2-tert-butyl-5-methylphenol)
* 4,4'-Thiobis(6-tert-butyl-3-methylphenol)
* 4,4'-Thiobis(2-(1,1-dimethylethyl)-5-methylphenol)
* 4,4'-Thiobis(3-methyl-6-tert-butylphenol)
* 1,1'-Thiobis(2-methyl-4-hydroxy-5-tert-butylbenzene)
* USAF B-15
* Yoshinox S
* Yoshinox SR
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2345 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IPSTB3 International Polymer Science and Technology. (Rapra Technology
Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK) Volume(issue)/page/year:
3,93,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 3200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IPSTB3 International Polymer Science and Technology. (Rapra Technology
Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK) Volume(issue)/page/year:
3,93,1976
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5475 mg/kg/15D-C
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from stomach
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Blood - changes in leukocyte (WBC) count
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-435,1994
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 15015 mg/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - normocytic anemia
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-435,1994
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1400 mg/kg/14D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in spleen weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
etc.)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
10,691,1988
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 5915 mg/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in spleen weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-435,1994
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 10 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
OSHA PEL (Gen Indu):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Gen Indu):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Construc):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Shipyard):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-FRANCE:TWA 10 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 10 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 10 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 10 mg/m3;STEL 20 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 10 mg/m3;STEL 20 mg/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO 4,4'-THIOBIS(6-t-BUTYL-m-CRESOL), dust-air:TWA 10 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO 4,4'-THIOBIS(6-t-BUTYL-m-CRESOL)-air:10H TWA 5 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84755
No. of Facilities: 4402 (estimated)
No. of Industries: 51
No. of Occupations: 47
No. of Employees: 36695 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84755
No. of Facilities: 1286 (estimated)
No. of Industries: 10
No. of Occupations: 11
No. of Employees: 12349 (estimated)
No. of Female Employees: 2177 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9277;8EHQ-0892-9283
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NTP Carcinogenesis Studies (feed);No evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-435,94
*** END OF RECORD ***
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