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MSDS  : p-Acetophenetidide
CAS  : 62-44-2
SYNONYMS  : * Acetamide, N-(4-ethoxyphenyl)- * 1-Acetamido-4-ethoxybenzene * Acetanilide, 4'-ethoxy- * Aceto-para-phenalide * p-Acetophenetide * Aceto-para-phenetidide * para-Acetophenetidide * Acetophenetidin * Acetophenetidine * p-Acetophenetidine * Aceto-4-phenetidine * Acetophenetin * Acet-p-phenalide * Acetphenetidin * p-Acetphenetidin * Acet-p-phenetidin * Acetylphenetidin * N-Acetyl-p-phenetidine * Achrocidin * Anapac * ASA compound * Bromo seltzer * Buff-A-Comp * Citra-fort * Clistanol * Codempiral * Commotional * Contradol * Contradouleur * Coricidin * Coriforte * Coryban-D * Daprisal * Darvon compound * Dasikon * Dasin * Dasin CH * Dolostop * Edrisal * Empiral * Emprazil * Emprazil-C * Epragen * p-Ethoxyacetanilide * 4-Ethoxyacetanilide * 4'-Ethoxyacetanilide * p-Ethoxyanilid kyseliny octove * N-para-Ethoxyphenylacetamide * N-(4-Ethoxyphenyl)acetamide * Fenacetin * Fenacetina * Fenidina * Fenia * Fenina * Fiorinal * Fortacyl * Gelonida * Gewodin * Helvagit * Hjorton's powder * Hocophen * KAFA * Kalmin * Malex * Melabon * Melaforte * Norgesic * Pamprin * Paracetophenetidin * Paramette * Paratodol * Pertonal * Phenacetin * para-Phenacetin * Phenacetine * Phenacetinum * Phenacitin * Phenacon * Phenaphen * Phenaphen plus * Phenazetin * Phenazetina * Phenedina * p-Phenetidine, N-acetyl- * Phenidin * Phenin * Phenodyne * Pyraphen * Pyrroxate * Quadronal * RCRA waste number U187 * Robaxisal-PH * Salgydal * Sanalgine * Saridon * Seranex * Sinedal * Sinubid * Sinutab * Stellacyl * Super anahist * Supralgin * Synalgos-DC * Synalogos * Tacol * Terracydin * Tetracydin * Thephorin A-C * Treupel * Veganine * Viden * Wigraine * Xaril * Zactirin compound
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : AM4375000
CHEMICAL NAME : p-Acetophenetidide
CAS REGISTRY NUMBER : 62-44-2
BEILSTEIN REFERENCE NO. : 1869238
REFERENCE : 4-13-00-01092 (Beilstein Handbook Reference)
LAST UPDATED : 199709
DATA ITEMS CITED : 77
MOLECULAR FORMULA : C10-H13-N-O2
MOLECULAR WEIGHT : 179.24
WISWESSER LINE NOTATION : 2OR DMV1
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Acetamide, N-(4-ethoxyphenyl)-
* 1-Acetamido-4-ethoxybenzene
* Acetanilide, 4'-ethoxy-
* Aceto-para-phenalide
* p-Acetophenetide
* Aceto-para-phenetidide
* para-Acetophenetidide
* Acetophenetidin
* Acetophenetidine
* p-Acetophenetidine
* Aceto-4-phenetidine
* Acetophenetin
* Acet-p-phenalide
* Acetphenetidin
* p-Acetphenetidin
* Acet-p-phenetidin
* Acetylphenetidin
* N-Acetyl-p-phenetidine
* Achrocidin
* Anapac
* ASA compound
* Bromo seltzer
* Buff-A-Comp
* Citra-fort
* Clistanol
* Codempiral
* Commotional
* Contradol
* Contradouleur
* Coricidin
* Coriforte
* Coryban-D
* Daprisal
* Darvon compound
* Dasikon
* Dasin
* Dasin CH
* Dolostop
* Edrisal
* Empiral
* Emprazil
* Emprazil-C
* Epragen
* p-Ethoxyacetanilide
* 4-Ethoxyacetanilide
* 4'-Ethoxyacetanilide
* p-Ethoxyanilid kyseliny octove
* N-para-Ethoxyphenylacetamide
* N-(4-Ethoxyphenyl)acetamide
* Fenacetin
* Fenacetina
* Fenidina
* Fenia
* Fenina
* Fiorinal
* Fortacyl
* Gelonida
* Gewodin
* Helvagit
* Hjorton's powder
* Hocophen
* KAFA
* Kalmin
* Malex
* Melabon
* Melaforte
* Norgesic
* Pamprin
* Paracetophenetidin
* Paramette
* Paratodol
* Pertonal
* Phenacetin
* para-Phenacetin
* Phenacetine
* Phenacetinum
* Phenacitin
* Phenacon
* Phenaphen
* Phenaphen plus
* Phenazetin
* Phenazetina
* Phenedina
* p-Phenetidine, N-acetyl-
* Phenidin
* Phenin
* Phenodyne
* Pyraphen
* Pyrroxate
* Quadronal
* RCRA waste number U187
* Robaxisal-PH
* Salgydal
* Sanalgine
* Saridon
* Seranex
* Sinedal
* Sinubid
* Sinutab
* Stellacyl
* Super anahist
* Supralgin
* Synalgos-DC
* Synalogos
* Tacol
* Terracydin
* Tetracydin
* Thephorin A-C
* Treupel
* Veganine
* Viden
* Wigraine
* Xaril
* Zactirin compound

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - man
DOSE/DURATION : 74 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M.,
Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 24,600,1974

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 634 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year:
62,11,1966

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 866 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 28,1644,1978

TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 33900 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 34(10),36,1969

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 540 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15
Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-
Volume(issue)/page/year: 81,659,1961

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1625 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 8,25,1958

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 260 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB282-666

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 21(9),53,1977

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 21,719,1971

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 1870 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
2,23,1960

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 1690 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
Behavioral - coma
Cardiac - pulse rate increase, without fall in BP
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year:
8,572,1953

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10 gm/kg/4W-I
TOXIC EFFECTS :
Blood - methemoglobinemia-carboxyhemoglobin
Blood - changes in other cell count (unspecified)
Blood - changes in erythrocyte (RBC) count
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 15,153,1983

TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 190 mg/m3/4H/30D-I
TOXIC EFFECTS :
Behavioral - alteration of classical conditioning
Liver - liver function tests impaired
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 34(10),36,1969

TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 15 mg/m3/4H/17W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Kidney, Ureter, Bladder - proteinuria
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 21(9),53,1977

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 16 gm/kg/43W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
26,105,1968

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 5625 mg/kg/9W-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Blood - changes in erythrocyte (RBC) count
Related to Chronic Data - death
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 15,727,1965

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 80 gm/kg/63Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
JOURAA Journal of Urology. (Williams & Wilkins Co., 428 E. Preston St.,
Baltimore, MD 21202) V.1- 1917- Volume(issue)/page/year: 113,653,1975

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 57 gm/kg/47Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
JOURAA Journal of Urology. (Williams & Wilkins Co., 428 E. Preston St.,
Baltimore, MD 21202) V.1- 1917- Volume(issue)/page/year: 113,653,1975

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 7300 mg/kg/Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
SJUNAS Scandinavian Journal of Urology and Nephrology. (Almqvist & Wiksell,
POB 45150, S-10430 Stockholm, Sweden) V.1- 1967-
Volume(issue)/page/year: 2,145,1968

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 572 gm/kg/60W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
Kidney, Ureter, Bladder - tumors
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75,
1907-84. For publisher information, see JJCREP. Volume(issue)/page/year:
70,29,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1008 gm/kg/96W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - tumors
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
Volume(issue)/page/year: 29,439,1982

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 19200 mg/kg/24W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.1- 1955- Volume(issue)/page/year: 32(5),63,1986

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 484 gm/kg/96W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
Volume(issue)/page/year: 29,439,1982

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 27 gm/kg/10Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
AAJRDX AJR, American Journal of Roentgenology. (Williams & Wilkins Co., 428
E. Preston St., Baltimore, MD 21202) V.126- 1976-
Volume(issue)/page/year: 134,1259,1980

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 9450 mg/kg/45W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
ADIRDF Advances in Inflammation Research. (Raven Press, 1185 Ave. of the
Americas, New York, NY 10036) V.1- 1979- Volume(issue)/page/year:
6,139,1984

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 206 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Sense Organs and Special Senses (Ear) - effect, not otherwise specified
Skin and Appendages - tumors
REFERENCE :
AMBPBZ Acta Pathologica et Microbiologica Scandinavica, Section A:
Pathology. (Copenhagen, Denmark) V.78-89, 1970-81. For publisher
information, see ACPADQ. Volume(issue)/page/year: 84,375,1976

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 28 gm/kg/28Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - tumors
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 20,192,1979

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 126 gm/kg/25Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - tumors
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200
Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year:
93,249,1980

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 140 gm/kg/13Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
BJURAN British Journal of Urology. (Longman Group Ltd., POB 11318,
Birmingham, AL 35202) V.1- 1929- Volume(issue)/page/year: 51,188,1979

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 50336 mg/kg
SEX/DURATION : male 17 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating
females per # males exposed to fertile nonpregnant females)
REFERENCE :
JCNDBK Journal of Clinical Pharmacology and New Drugs. (Stamford, CT)
V.11-13, 1971-73. For publisher information, see JCPCBR.
Volume(issue)/page/year: 11,96,1971

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 24 gm/kg
SEX/DURATION : female 1-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year:
43,364,1965

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 6 gm/kg
SEX/DURATION : female 1-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year:
43,364,1965

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 62920 mg/kg
SEX/DURATION : male 22 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
JCNDBK Journal of Clinical Pharmacology and New Drugs. (Stamford, CT)
V.11-13, 1971-73. For publisher information, see JCPCBR.
Volume(issue)/page/year: 11,96,1971

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 57200 mg/kg
SEX/DURATION : male 20 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
REFERENCE :
JCNDBK Journal of Clinical Pharmacology and New Drugs. (Stamford, CT)
V.11-13, 1971-73. For publisher information, see JCPCBR.
Volume(issue)/page/year: 11,96,1971

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 333 ug/plate
REFERENCE :
IAPUDO IARC Publications. (WHO Publications Centre USA, 49 Sheridan Ave.,
Albany, NY 12210) No.27- 1979- Volume(issue)/page/year: 27,283,1980

TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 2 mg/well
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 16,355,1985

TYPE OF TEST : DNA damage
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 2500 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 368,235,1996

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 1500 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 196,61,1988

TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 2 gm/kg/2D (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 347,73,1995

TYPE OF TEST : DNA damage
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 165 mg/kg
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 16,355,1985

TYPE OF TEST : DNA damage
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 82500 ug/kg
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 16,355,1985

TYPE OF TEST : Body fluid assay
TEST SYSTEM : Rodent - rat Bacteria - Salmonella typhimurium
DOSE/DURATION : 800 mg/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
42,3201,1982

TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 263 gm/kg/17W (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 79,13,1980

TYPE OF TEST : Host-mediated assay
TEST SYSTEM : Rodent - rat Bacteria - Salmonella typhimurium
DOSE/DURATION : 200 ug/kg
REFERENCE :
ONCODU Revista de Chirurgui, Oncologie, Radiologie, ORL, Oftalmologie,
Stomatologie, Seria: Oncologia. (Rompresfilatelia, POB 12-201, Bucharest,
Romania) V.13(4)- 1974- Volume(issue)/page/year: 19,183,1980

TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 2 mg/kg
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 80,761,1991

TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 600 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 223,365,1989

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 500 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 196,61,1988

TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - mouse Embryo
DOSE/DURATION : 500 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
49,1038,1989

TYPE OF TEST : DNA damage
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 400 mg/kg
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
Volume(issue)/page/year: 5,355,1982

TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 20 gm/kg
REFERENCE :
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit
Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949-
Volume(issue)/page/year: 51,605,1981

TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION : 50 mg/L
REFERENCE :
ONCODU Revista de Chirurgui, Oncologie, Radiologie, ORL, Oftalmologie,
Stomatologie, Seria: Oncologia. (Rompresfilatelia, POB 12-201, Bucharest,
Romania) V.13(4)- 1974- Volume(issue)/page/year: 19,183,1980

TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - mouse Fibroblast
DOSE/DURATION : 1 mmol/L
REFERENCE :
JOUOD4 Journal of UOEH (University of Occupational and Environmental
Health). (Univ. of Occupational and Environmental Health, 1-1 Iseigaoka,
Yahata-nishi-ku, Kitakyushu 807, Japan) V.1- 1979-
Volume(issue)/page/year: 5,147,1983

TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 165 mg/kg
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 16,355,1985

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 1 mmol/L
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 16,355,1985

TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 3 mmol/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,51,1988

TYPE OF TEST : Body fluid assay
TEST SYSTEM : Rodent - hamster Bacteria - Salmonella typhimurium
DOSE/DURATION : 1600 mg/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
42,3201,1982

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Fibroblast
DOSE/DURATION : 800 mg/L/48H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 48,337,1977

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 800 mg/L/27H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 66,277,1979

TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 100 mg/L
REFERENCE :
SHIGAZ Shigaku. Ondotology. (Nippon Shika Daigaku Shigakkai, 1-9-20
Fujimi, Chiyodaku, Tokyo 102, Japan) V.38- 1949-
Volume(issue)/page/year: 70,924,1983

*** REVIEWS ***

IARC Cancer Review:Animal Sufficient Evidence
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,310,1987

IARC Cancer Review:Human Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 24,135,1980

IARC Cancer Review:Group 2A
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,310,1987

TOXICOLOGY REVIEW
JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO
63132) V.3- 1969- Volume(issue)/page/year: 12,27,1974

TOXICOLOGY REVIEW
AUHPAI Australian Journal of Hospital Pharmacy. (B.R. Miller, POB 125,
Heidelberg, Vic., Australia) V.1- 1971- Volume(issue)/page/year:
3(3),100,1973

TOXICOLOGY REVIEW
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 2,1233,1969

TOXICOLOGY REVIEW
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New
York, NY 10022) V.1- 1946- Volume(issue)/page/year: 38,409,1965

TOXICOLOGY REVIEW
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
Volume(issue)/page/year: 33,743,1974

TOXICOLOGY REVIEW
ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution
Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1-
1950- Volume(issue)/page/year: 13,271,1970

TOXICOLOGY REVIEW
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York,
NY 10003) V.1- 1973- Volume(issue)/page/year: 24,253,1983

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-RUSSIA:STEL 0.5 mg/m3 JAN 1993

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80478
No. of Facilities: 126 (estimated)
No. of Industries: 2
No. of Occupations: 10
No. of Employees: 4186 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4389
No. of Facilities: 9 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 869 (estimated)
No. of Female Employees: 617 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80478
No. of Facilities: 1271 (estimated)
No. of Industries: 4
No. of Occupations: 12
No. of Employees: 18808 (estimated)
No. of Female Employees: 15338 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat

EPA TSCA Section 8(b) CHEMICAL INVENTORY

NTP 7th Annual Report on Carcinogens, 1992 : anticipated to be carcinogen


*** END OF RECORD ***
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NAMECAS
Acetonitrile, (3,4,5-trimethoxyphenyl)- 13338-63-1
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m-Acetophenetidide 591-33-3
o-Acetophenetidide 581-08-8
p-Acetophenetidide 62-44-2
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Acetohydroxamic acid, N-(2-naphthyl)- 2508-23-8
p-Acetophenetidide, 3'-acetyl-beta-methoxy- 670-64-4
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m-Acetophenetidide,2-(p-butoxyphenoxy)-N-(2-(diethylamino)ethyl)-,monohydrochloride 27471-62-1
p-Acetophenetidide, 2-(butylamino)-, hydrochloride 77966-25-7
m-Acetophenetidide, 2-chloro- 17641-12-2
p-Acetophenetidide, 2-chloro- 2153-08-4
o-Acetophenetidide, 2-(diethylamino)-, hydrochloride 77966-26-8
p-Acetophenetidide, 2-(diethylamino)-, hydrochloride 77966-27-9
p-Acetophenetidide, N-(diethylcarbamoylmethyl)- 97555-47-0
p-Acetophenetidide,2-dimethylamino-N-(dimethylcarbamoylmethyl)- 89169-47-1
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p-Acetophenetidide, N-(2-(dimethylamino)ethyl)-,fumarate 39735-49-4
p-Acetophenetidide, 2-(dimethylamino)-, hydrochloride 39735-49-4
p-Acetophenetidide,N-(2-(dimethylamino)-1-methylethyl)-, salicylate 39735-49-4
p-Acetophenetidide, N-(3-(dimethylamino)propyl)-,fumarate 39735-49-4
p-Acetophenetidide, N-(1-dimethylcarbamoylethyl)- 97441-73-1
o-Acetophenetidide, N-(dimethylcarbamoylmethyl)- 97214-80-7
p-Acetophenetidide, N-((dimethylcarbamoyl)methyl)- 3736-41-2
p-Acetophenetidide, N-ethyl- 66922-67-6
m-Acetophenetidide, 2-iodo- 17641-14-4
p-Acetophenetidide, 2-iodo- 17641-13-3
Acetohydroxamic acid, (p-tert-pentyl)phenyl- 63884-95-7
p-Acetophenetidide, 2'-isopropyl-5'-methyl- 63884-95-7
p-Acetophenetidide, 5'-isopropyl-2'-methyl- 63884-95-7
p-Acetophenetidide, N-methyl- 7298-73-9
p-Acetophenetidide, 3-nitro- 1777-84-0
p-Acetophenetidide, 2'-nitro-N-nitroso- 15862-16-5
p-Acetophenetidide, N-nitroso- 15862-11-0
p-Acetophenetidide, 2-piperidino-, hydrochloride 73693-97-7
p-Acetophenetidide, 2-pyrrolidinyl-, hydrochloride 77966-28-0
p-Acetophenetidide, 2,2,2-trifluoro- 457-53-4
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Acetophenone, p-acetamido-, 1-thiosemicarbazone 7441-55-6
Acetophenone, 4'-(9-acridinylamino)- 73655-62-6
Acetophenone, 4'-(allyloxy)- 2079-53-0
Acetophenone, 4-allyloxy-3,5-dimethoxy- 66922-68-7
Acetophenone, 4'-(allyloxy)-, oxime 66922-68-7
Acetophenone, 4-(5-amidinofuryl)-, monohydrochloride 57667-28-4
Acetophenone, 4'-(amidinoguanidino)-,amidinohydrazone, dihydrochloride 57667-28-4
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