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MSDS  
:
 p-Acetophenetidide
CAS  
:
 62-44-2
SYNONYMS  
:
 * Acetamide, N-(4-ethoxyphenyl)-
* 1-Acetamido-4-ethoxybenzene
* Acetanilide, 4'-ethoxy-
* Aceto-para-phenalide
* p-Acetophenetide
* Aceto-para-phenetidide
* para-Acetophenetidide
* Acetophenetidin
* Acetophenetidine
* p-Acetophenetidine
* Aceto-4-phenetidine
* Acetophenetin
* Acet-p-phenalide
* Acetphenetidin
* p-Acetphenetidin
* Acet-p-phenetidin
* Acetylphenetidin
* N-Acetyl-p-phenetidine
* Achrocidin
* Anapac
* ASA compound
* Bromo seltzer
* Buff-A-Comp
* Citra-fort
* Clistanol
* Codempiral
* Commotional
* Contradol
* Contradouleur
* Coricidin
* Coriforte
* Coryban-D
* Daprisal
* Darvon compound
* Dasikon
* Dasin
* Dasin CH
* Dolostop
* Edrisal
* Empiral
* Emprazil
* Emprazil-C
* Epragen
* p-Ethoxyacetanilide
* 4-Ethoxyacetanilide
* 4'-Ethoxyacetanilide
* p-Ethoxyanilid kyseliny octove
* N-para-Ethoxyphenylacetamide
* N-(4-Ethoxyphenyl)acetamide
* Fenacetin
* Fenacetina
* Fenidina
* Fenia
* Fenina
* Fiorinal
* Fortacyl
* Gelonida
* Gewodin
* Helvagit
* Hjorton's powder
* Hocophen
* KAFA
* Kalmin
* Malex
* Melabon
* Melaforte
* Norgesic
* Pamprin
* Paracetophenetidin
* Paramette
* Paratodol
* Pertonal
* Phenacetin
* para-Phenacetin
* Phenacetine
* Phenacetinum
* Phenacitin
* Phenacon
* Phenaphen
* Phenaphen plus
* Phenazetin
* Phenazetina
* Phenedina
* p-Phenetidine, N-acetyl-
* Phenidin
* Phenin
* Phenodyne
* Pyraphen
* Pyrroxate
* Quadronal
* RCRA waste number U187
* Robaxisal-PH
* Salgydal
* Sanalgine
* Saridon
* Seranex
* Sinedal
* Sinubid
* Sinutab
* Stellacyl
* Super anahist
* Supralgin
* Synalgos-DC
* Synalogos
* Tacol
* Terracydin
* Tetracydin
* Thephorin A-C
* Treupel
* Veganine
* Viden
* Wigraine
* Xaril
* Zactirin compound

                     *** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AM4375000
CHEMICAL NAME           : p-Acetophenetidide
CAS REGISTRY NUMBER     : 62-44-2
BEILSTEIN REFERENCE NO. : 1869238
REFERENCE               : 4-13-00-01092 (Beilstein Handbook Reference)
LAST UPDATED            : 199709
DATA ITEMS CITED        : 77
MOLECULAR FORMULA       : C10-H13-N-O2
MOLECULAR WEIGHT        : 179.24
WISWESSER LINE NOTATION : 2OR DMV1
COMPOUND DESCRIPTOR     : Tumorigen
                          Drug
                          Mutagen
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Acetamide, N-(4-ethoxyphenyl)-
   * 1-Acetamido-4-ethoxybenzene
   * Acetanilide, 4'-ethoxy-
   * Aceto-para-phenalide
   * p-Acetophenetide
   * Aceto-para-phenetidide
   * para-Acetophenetidide
   * Acetophenetidin
   * Acetophenetidine
   * p-Acetophenetidine
   * Aceto-4-phenetidine
   * Acetophenetin
   * Acet-p-phenalide
   * Acetphenetidin
   * p-Acetphenetidin
   * Acet-p-phenetidin
   * Acetylphenetidin
   * N-Acetyl-p-phenetidine
   * Achrocidin
   * Anapac
   * ASA compound
   * Bromo seltzer
   * Buff-A-Comp
   * Citra-fort
   * Clistanol
   * Codempiral
   * Commotional
   * Contradol
   * Contradouleur
   * Coricidin
   * Coriforte
   * Coryban-D
   * Daprisal
   * Darvon compound
   * Dasikon
   * Dasin
   * Dasin CH
   * Dolostop
   * Edrisal
   * Empiral
   * Emprazil
   * Emprazil-C
   * Epragen
   * p-Ethoxyacetanilide
   * 4-Ethoxyacetanilide
   * 4'-Ethoxyacetanilide
   * p-Ethoxyanilid kyseliny octove
   * N-para-Ethoxyphenylacetamide
   * N-(4-Ethoxyphenyl)acetamide
   * Fenacetin
   * Fenacetina
   * Fenidina
   * Fenia
   * Fenina
   * Fiorinal
   * Fortacyl
   * Gelonida
   * Gewodin
   * Helvagit
   * Hjorton's powder
   * Hocophen
   * KAFA
   * Kalmin
   * Malex
   * Melabon
   * Melaforte
   * Norgesic
   * Pamprin
   * Paracetophenetidin
   * Paramette
   * Paratodol
   * Pertonal
   * Phenacetin
   * para-Phenacetin
   * Phenacetine
   * Phenacetinum
   * Phenacitin
   * Phenacon
   * Phenaphen
   * Phenaphen plus
   * Phenazetin
   * Phenazetina
   * Phenedina
   * p-Phenetidine, N-acetyl-
   * Phenidin
   * Phenin
   * Phenodyne
   * Pyraphen
   * Pyrroxate
   * Quadronal
   * RCRA waste number U187
   * Robaxisal-PH
   * Salgydal
   * Sanalgine
   * Saridon
   * Seranex
   * Sinedal
   * Sinubid
   * Sinutab
   * Stellacyl
   * Super anahist
   * Supralgin
   * Synalgos-DC
   * Synalogos
   * Tacol
   * Terracydin
   * Tetracydin
   * Thephorin A-C
   * Treupel
   * Veganine
   * Viden
   * Wigraine
   * Xaril
   * Zactirin compound
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 74 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M.,
   Springfield, IL, C.C. Thomas, 1970  Volume(issue)/page/year: 2,73,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 24,600,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 634 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   62,11,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 866 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 28,1644,1978
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 33900 mg/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 34(10),36,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 540 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 81,659,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1625 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 8,25,1958
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 260 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB282-666
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 21(9),53,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 21,719,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 1870 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   2,23,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 1690 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Behavioral - coma
   Cardiac - pulse rate increase, without fall in BP
REFERENCE :
   PHARAT Pharmazie.  (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
   Berlin DDR-1020, Ger. Dem. Rep.)  V.1-    1946-  Volume(issue)/page/year:
   8,572,1953
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10 gm/kg/4W-I
TOXIC EFFECTS :
   Blood - methemoglobinemia-carboxyhemoglobin
   Blood - changes in other cell count (unspecified)
   Blood - changes in erythrocyte (RBC) count
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 15,153,1983
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 190 mg/m3/4H/30D-I
TOXIC EFFECTS :
   Behavioral - alteration of classical conditioning
   Liver - liver function tests impaired
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 34(10),36,1969
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15 mg/m3/4H/17W-I
TOXIC EFFECTS :
   Brain and Coverings - recordings from specific areas of CNS
   Kidney, Ureter, Bladder - proteinuria
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 21(9),53,1977
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 16 gm/kg/43W-C
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   26,105,1968
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 5625 mg/kg/9W-I
TOXIC EFFECTS :
   Blood - pigmented or nucleated red blood cells
   Blood - changes in erythrocyte (RBC) count
   Related to Chronic Data - death
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 15,727,1965
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 80 gm/kg/63Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   JOURAA Journal of Urology.  (Williams & Wilkins Co., 428 E. Preston St.,
   Baltimore, MD  21202) V.1-    1917-  Volume(issue)/page/year: 113,653,1975
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 57 gm/kg/47Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   JOURAA Journal of Urology.  (Williams & Wilkins Co., 428 E. Preston St.,
   Baltimore, MD  21202) V.1-    1917-  Volume(issue)/page/year: 113,653,1975
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 7300 mg/kg/Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   SJUNAS Scandinavian Journal of Urology and Nephrology.  (Almqvist & Wiksell,
   POB 45150, S-10430 Stockholm, Sweden)  V.1-    1967-
   Volume(issue)/page/year: 2,145,1968
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 572 gm/kg/60W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Sense Organs and Special Senses (Olfaction) - tumors
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
   70,29,1979
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1008 gm/kg/96W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - tumors
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   IJCNAW International Journal of Cancer.  (International Union Against
   Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland)  V.1-    1966-
   Volume(issue)/page/year: 29,439,1982
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 19200 mg/kg/24W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   VOONAW Voprosy Onkologii.  Problems of Oncology.  For English translation,
   see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-10,
   1928-37; V.1-    1955-  Volume(issue)/page/year: 32(5),63,1986
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 484 gm/kg/96W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   IJCNAW International Journal of Cancer.  (International Union Against
   Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland)  V.1-    1966-
   Volume(issue)/page/year: 29,439,1982
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 27 gm/kg/10Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   AAJRDX AJR, American Journal of Roentgenology.  (Williams & Wilkins Co., 428
   E. Preston St., Baltimore, MD 21202)  V.126-    1976-
   Volume(issue)/page/year: 134,1259,1980
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9450 mg/kg/45W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   ADIRDF Advances in Inflammation Research.  (Raven Press, 1185 Ave. of the
   Americas, New York, NY 10036)  V.1-    1979-  Volume(issue)/page/year:
   6,139,1984
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 206 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Sense Organs and Special Senses (Ear) - effect, not otherwise specified
   Skin and Appendages - tumors
REFERENCE :
   AMBPBZ Acta Pathologica et Microbiologica Scandinavica, Section A:
   Pathology.  (Copenhagen, Denmark) V.78-89, 1970-81.  For publisher
   information, see ACPADQ.  Volume(issue)/page/year: 84,375,1976
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 28 gm/kg/28Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   ENVRAL Environmental Research.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.1-    1967-  Volume(issue)/page/year: 20,192,1979
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 126 gm/kg/25Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   AIMEAS Annals of Internal Medicine.  (American College of Physicians, 4200
   Pine St., Philadelphia, PA 19104)  V.1-    1927-  Volume(issue)/page/year:
   93,249,1980
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 140 gm/kg/13Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   BJURAN British Journal of Urology.  (Longman Group Ltd., POB 11318,
   Birmingham, AL 35202) V.1-    1929-  Volume(issue)/page/year: 51,188,1979
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 50336 mg/kg
SEX/DURATION            : male 17 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   JCNDBK Journal of Clinical Pharmacology and New Drugs.  (Stamford, CT)
   V.11-13, 1971-73.  For publisher information, see JCPCBR.
   Volume(issue)/page/year: 11,96,1971
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 24 gm/kg
SEX/DURATION            : female 1-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   KLWOAZ Klinische Wochenscrift.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.1-    1922-  Volume(issue)/page/year:
   43,364,1965
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 6 gm/kg
SEX/DURATION            : female 1-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   KLWOAZ Klinische Wochenscrift.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.1-    1922-  Volume(issue)/page/year:
   43,364,1965
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 62920 mg/kg
SEX/DURATION            : male 22 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   JCNDBK Journal of Clinical Pharmacology and New Drugs.  (Stamford, CT)
   V.11-13, 1971-73.  For publisher information, see JCPCBR.
   Volume(issue)/page/year: 11,96,1971
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 57200 mg/kg
SEX/DURATION            : male 20 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   JCNDBK Journal of Clinical Pharmacology and New Drugs.  (Stamford, CT)
   V.11-13, 1971-73.  For publisher information, see JCPCBR.
   Volume(issue)/page/year: 11,96,1971
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 333 ug/plate
REFERENCE :
   IAPUDO IARC Publications.  (WHO Publications Centre USA, 49 Sheridan Ave.,
   Albany, NY 12210) No.27-    1979-  Volume(issue)/page/year: 27,283,1980
 
TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 2 mg/well
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 16,355,1985
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 2500 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 368,235,1996
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 1500 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 196,61,1988
 
TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 2 gm/kg/2D (Continuous)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 347,73,1995
 
TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 165 mg/kg
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 16,355,1985
 
TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 82500 ug/kg
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 16,355,1985
 
TYPE OF TEST            : Body fluid assay
TEST SYSTEM             : Rodent - rat Bacteria - Salmonella typhimurium
DOSE/DURATION           : 800 mg/kg
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   42,3201,1982
 
TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 263 gm/kg/17W (Continuous)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 79,13,1980
 
TYPE OF TEST            : Host-mediated assay
TEST SYSTEM             : Rodent - rat Bacteria - Salmonella typhimurium
DOSE/DURATION           : 200 ug/kg
REFERENCE :
   ONCODU Revista de Chirurgui, Oncologie, Radiologie, ORL, Oftalmologie,
   Stomatologie, Seria: Oncologia.  (Rompresfilatelia, POB 12-201, Bucharest,
   Romania)  V.13(4)-    1974-  Volume(issue)/page/year: 19,183,1980
 
TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 2 mg/kg
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 80,761,1991
 
TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 600 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 223,365,1989
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 500 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 196,61,1988
 
TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Embryo
DOSE/DURATION           : 500 mg/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   49,1038,1989
 
TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
REFERENCE :
   ATSUDG Archives of Toxicology, Supplement.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  No.1-    1978-
   Volume(issue)/page/year: 5,355,1982
 
TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 20 gm/kg
REFERENCE :
   ARGEAR Archiv fuer Geschwulstforschung.  (VEB Verlag Volk und Gesundheit
   Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.)  V.1-    1949-
   Volume(issue)/page/year: 51,605,1981
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 50 mg/L
REFERENCE :
   ONCODU Revista de Chirurgui, Oncologie, Radiologie, ORL, Oftalmologie,
   Stomatologie, Seria: Oncologia.  (Rompresfilatelia, POB 12-201, Bucharest,
   Romania)  V.13(4)-    1974-  Volume(issue)/page/year: 19,183,1980
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Fibroblast
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   JOUOD4 Journal of UOEH (University of Occupational and Environmental
   Health).  (Univ. of Occupational and Environmental Health, 1-1 Iseigaoka,
   Yahata-nishi-ku, Kitakyushu 807, Japan) V.1-    1979-
   Volume(issue)/page/year: 5,147,1983
 
TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 165 mg/kg
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 16,355,1985
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 16,355,1985
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 3 mmol/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 3,51,1988
 
TYPE OF TEST            : Body fluid assay
TEST SYSTEM             : Rodent - hamster Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1600 mg/kg
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   42,3201,1982
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 800 mg/L/48H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 48,337,1977
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 800 mg/L/27H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 66,277,1979
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 100 mg/L
REFERENCE :
   SHIGAZ Shigaku.  Ondotology.  (Nippon Shika Daigaku Shigakkai, 1-9-20
   Fujimi, Chiyodaku, Tokyo 102, Japan)  V.38-    1949-
   Volume(issue)/page/year: 70,924,1983

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Sufficient Evidence
   IMSUDL IARC Monographs, Supplement.  (WHO Publications Centre USA, 49
   Sheridan Ave., Albany, NY 12210)  No.1-    1979-  Volume(issue)/page/year:
   7,310,1987

   IARC Cancer Review:Human Limited Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 24,135,1980

   IARC Cancer Review:Group 2A
   IMSUDL IARC Monographs, Supplement.  (WHO Publications Centre USA, 49
   Sheridan Ave., Albany, NY 12210)  No.1-    1979-  Volume(issue)/page/year:
   7,310,1987

   TOXICOLOGY REVIEW
   JRPMAP Journal of Reproductive Medicine.  (2 Jacklynn Ct., St. Louis, MO
   63132)  V.3-    1969-  Volume(issue)/page/year: 12,27,1974

   TOXICOLOGY REVIEW
   AUHPAI Australian Journal of Hospital Pharmacy.  (B.R. Miller, POB 125,
   Heidelberg, Vic., Australia) V.1-    1971-  Volume(issue)/page/year:
   3(3),100,1973

   TOXICOLOGY REVIEW
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 2,1233,1969

   TOXICOLOGY REVIEW
   AJMEAZ American Journal of Medicine.  (Technical Pub., 875 Third Ave., New
   York, NY 10022) V.1-    1946-  Volume(issue)/page/year: 38,409,1965

   TOXICOLOGY REVIEW
   CANCAR Cancer (Philadelphia).  (Lippincott/Harper, Journal Fulfillment
   Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1948-
   Volume(issue)/page/year: 33,743,1974

   TOXICOLOGY REVIEW
   ADCSAJ Advances in Chemistry Series.  (American Chemical Soc., Distribution
   Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037)  No.1-
   1950-  Volume(issue)/page/year: 13,271,1970

   TOXICOLOGY REVIEW
   BLFSBY Basic Life Sciences.  (Plenum Pub. Corp., 223 Spring St., New York,
   NY 10003)  V.1-    1973-  Volume(issue)/page/year: 24,253,1983

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-RUSSIA:STEL 0.5 mg/m3 JAN 1993

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 80478
       No. of Facilities: 126 (estimated)
       No. of Industries: 2
       No. of Occupations: 10
       No. of Employees: 4186 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X4389
       No. of Facilities: 9 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 869 (estimated)
       No. of Female Employees: 617 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 80478
       No. of Facilities: 1271 (estimated)
       No. of Industries: 4
       No. of Occupations: 12
       No. of Employees: 18808 (estimated)
       No. of Female Employees: 15338 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   NTP 7th Annual Report on Carcinogens, 1992 : anticipated to be carcinogen

 
                            *** END OF RECORD ***
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m-Acetophenetidide 591-33-3
o-Acetophenetidide 581-08-8
p-Acetophenetidide 62-44-2
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p-Acetophenetidide, 2-(butylamino)-, hydrochloride 77966-25-7
m-Acetophenetidide, 2-chloro- 17641-12-2
p-Acetophenetidide, 2-chloro- 2153-08-4
o-Acetophenetidide, 2-(diethylamino)-, hydrochloride 77966-26-8
p-Acetophenetidide, 2-(diethylamino)-, hydrochloride 77966-27-9
p-Acetophenetidide, N-(diethylcarbamoylmethyl)- 97555-47-0
p-Acetophenetidide,2-dimethylamino-N-(dimethylcarbamoylmethyl)- 89169-47-1
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p-Acetophenetidide, N-(2-(dimethylamino)ethyl)-,fumarate 39735-49-4
p-Acetophenetidide, 2-(dimethylamino)-, hydrochloride 39735-49-4
p-Acetophenetidide,N-(2-(dimethylamino)-1-methylethyl)-, salicylate 39735-49-4
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p-Acetophenetidide, N-(1-dimethylcarbamoylethyl)- 97441-73-1
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p-Acetophenetidide, N-ethyl- 66922-67-6
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p-Acetophenetidide, 2-iodo- 17641-13-3
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p-Acetophenetidide, 2'-isopropyl-5'-methyl- 63884-95-7
p-Acetophenetidide, 5'-isopropyl-2'-methyl- 63884-95-7
p-Acetophenetidide, N-methyl- 7298-73-9
p-Acetophenetidide, 3-nitro- 1777-84-0
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Acetophenone, p-acetamido-, 1-thiosemicarbazone 7441-55-6
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Acetophenone, 4'-(allyloxy)- 2079-53-0
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