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MSDS  : Acetophenone
CAS  : 98-86-2
SYNONYMS  : * Acetofenon * Acetophenon * Acetophenone * Acetylbenzene * Benzene, acetyl- * Benzoyl methide * Ethanone, 1-phenyl- * Hypnon * Hypnone * Ketone, methyl phenyl * Methyl phenyl ketone * 1-Phenylethanone * Phenyl methyl ketone * RCRA waste number U004 * USAF EK-496
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : AM5250000
CHEMICAL NAME : Acetophenone
CAS REGISTRY NUMBER : 98-86-2
LAST UPDATED : 199712
DATA ITEMS CITED : 22
MOLECULAR FORMULA : C8-H8-O
MOLECULAR WEIGHT : 120.16
WISWESSER LINE NOTATION : 1VR
COMPOUND DESCRIPTOR : Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Acetofenon
* Acetophenon
* Acetophenone
* Acetylbenzene
* Benzene, acetyl-
* Benzoyl methide
* Ethanone, 1-phenyl-
* Hypnon
* Hypnone
* Ketone, methyl phenyl
* Methyl phenyl ketone
* 1-Phenylethanone
* Phenyl methyl ketone
* RCRA waste number U004
* USAF EK-496

*** HEALTH HAZARD DATA ***

** SKIN/EYE IRRITATION DATA **

TYPE OF TEST : Open irritation test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 10 mg/24H
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 26,269,1944

TYPE OF TEST : Open irritation test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 515 mg
REACTION SEVERITY : Mild
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 12/27/1971

TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 750 ug
REACTION SEVERITY : Severe
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
Volume(issue)/page/year: 29,1363,1946

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 815 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 26(8),53,1982

TYPE OF TEST : LC - Lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >210 ppm/8H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 12/27/1971

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 740 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 26(8),53,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 330 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
HDTU** "Pharmakologische Prufung von Analgetika, Dissertation," Herrlen, G.,
Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1933
Volume(issue)/page/year: -,-,1933

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 15900 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 12/27/1971

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : >20 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 26,269,1944

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 2700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 32(10),25,1988

TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 1200 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 32(10),25,1988

** MUTATION DATA **

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 600 mg/L
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year:
(103),64,1985

*** REVIEWS ***

ACGIH TLV-TWA 49 mg/m3 (10 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-HUNGARY:TWA 15 mg/m3;STEL 30 mg/m3;Skin JAN 1993

OEL-RUSSIA:STEL 5 mg/m3;Skin JAN 1993

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80265
No. of Facilities: 4433 (estimated)
No. of Industries: 48
No. of Occupations: 61
No. of Employees: 78624 (estimated)
No. of Female Employees: 31148 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9; E coli polA with
S9

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

On EPA IRIS database

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998


*** END OF RECORD ***
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m-Acetophenetidide 591-33-3
o-Acetophenetidide 581-08-8
p-Acetophenetidide 62-44-2
Acetohydroxamic acid, N-(4'-fluoro-4-biphenylyl)- 76299-95-1
Acetohydroxamic acid, N-(2-naphthyl)- 2508-23-8
p-Acetophenetidide, 3'-acetyl-beta-methoxy- 670-64-4
p-Acetophenetidide, 3'-(bis(2-hydroxyethyl)amino)- 21615-29-2
m-Acetophenetidide,2-(p-butoxyphenoxy)-N-(2-(diethylamino)ethyl)-,monohydrochloride 27471-62-1
p-Acetophenetidide, 2-(butylamino)-, hydrochloride 77966-25-7
m-Acetophenetidide, 2-chloro- 17641-12-2
p-Acetophenetidide, 2-chloro- 2153-08-4
o-Acetophenetidide, 2-(diethylamino)-, hydrochloride 77966-26-8
p-Acetophenetidide, 2-(diethylamino)-, hydrochloride 77966-27-9
p-Acetophenetidide, N-(diethylcarbamoylmethyl)- 97555-47-0
p-Acetophenetidide,2-dimethylamino-N-(dimethylcarbamoylmethyl)- 89169-47-1
Acetohydroxamic acid, 2-(p-nitrobenzamido)- 39735-49-4
p-Acetophenetidide, N-(2-(dimethylamino)ethyl)-,fumarate 39735-49-4
p-Acetophenetidide, 2-(dimethylamino)-, hydrochloride 39735-49-4
p-Acetophenetidide,N-(2-(dimethylamino)-1-methylethyl)-, salicylate 39735-49-4
p-Acetophenetidide, N-(3-(dimethylamino)propyl)-,fumarate 39735-49-4
p-Acetophenetidide, N-(1-dimethylcarbamoylethyl)- 97441-73-1
o-Acetophenetidide, N-(dimethylcarbamoylmethyl)- 97214-80-7
p-Acetophenetidide, N-((dimethylcarbamoyl)methyl)- 3736-41-2
p-Acetophenetidide, N-ethyl- 66922-67-6
m-Acetophenetidide, 2-iodo- 17641-14-4
p-Acetophenetidide, 2-iodo- 17641-13-3
Acetohydroxamic acid, (p-tert-pentyl)phenyl- 63884-95-7
p-Acetophenetidide, 2'-isopropyl-5'-methyl- 63884-95-7
p-Acetophenetidide, 5'-isopropyl-2'-methyl- 63884-95-7
p-Acetophenetidide, N-methyl- 7298-73-9
p-Acetophenetidide, 3-nitro- 1777-84-0
p-Acetophenetidide, 2'-nitro-N-nitroso- 15862-16-5
p-Acetophenetidide, N-nitroso- 15862-11-0
p-Acetophenetidide, 2-piperidino-, hydrochloride 73693-97-7
p-Acetophenetidide, 2-pyrrolidinyl-, hydrochloride 77966-28-0
p-Acetophenetidide, 2,2,2-trifluoro- 457-53-4
Acetophenone 98-86-2
Acetohydroxamic acid, (p-pentylthio)phenyl- 63884-96-8
Acetophenone, p-acetamido-, 1-thiosemicarbazone 7441-55-6
Acetophenone, 4'-(9-acridinylamino)- 73655-62-6
Acetophenone, 4'-(allyloxy)- 2079-53-0
Acetophenone, 4-allyloxy-3,5-dimethoxy- 66922-68-7
Acetophenone, 4'-(allyloxy)-, oxime 66922-68-7
Acetophenone, 4-(5-amidinofuryl)-, monohydrochloride 57667-28-4
Acetophenone, 4'-(amidinoguanidino)-,amidinohydrazone, dihydrochloride 57667-28-4
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Acetophenone, 2-amino- 613-89-8

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