*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : AM5250000
CHEMICAL NAME : Acetophenone
CAS REGISTRY NUMBER : 98-86-2
LAST UPDATED : 199712
DATA ITEMS CITED : 22
MOLECULAR FORMULA : C8-H8-O
MOLECULAR WEIGHT : 120.16
WISWESSER LINE NOTATION : 1VR
COMPOUND DESCRIPTOR : Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Acetofenon
* Acetophenon
* Acetophenone
* Acetylbenzene
* Benzene, acetyl-
* Benzoyl methide
* Ethanone, 1-phenyl-
* Hypnon
* Hypnone
* Ketone, methyl phenyl
* Methyl phenyl ketone
* 1-Phenylethanone
* Phenyl methyl ketone
* RCRA waste number U004
* USAF EK-496
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Open irritation test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 10 mg/24H
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 26,269,1944
TYPE OF TEST : Open irritation test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 515 mg
REACTION SEVERITY : Mild
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 12/27/1971
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 750 ug
REACTION SEVERITY : Severe
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
Volume(issue)/page/year: 29,1363,1946
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 815 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 26(8),53,1982
TYPE OF TEST : LC - Lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >210 ppm/8H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 12/27/1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 740 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 26(8),53,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 330 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
HDTU** "Pharmakologische Prufung von Analgetika, Dissertation," Herrlen, G.,
Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1933
Volume(issue)/page/year: -,-,1933
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 15900 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 12/27/1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : >20 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 26,269,1944
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 2700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 32(10),25,1988
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 1200 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 32(10),25,1988
** MUTATION DATA **
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 600 mg/L
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year:
(103),64,1985
*** REVIEWS ***
ACGIH TLV-TWA 49 mg/m3 (10 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-HUNGARY:TWA 15 mg/m3;STEL 30 mg/m3;Skin JAN 1993
OEL-RUSSIA:STEL 5 mg/m3;Skin JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80265
No. of Facilities: 4433 (estimated)
No. of Industries: 48
No. of Occupations: 61
No. of Employees: 78624 (estimated)
No. of Female Employees: 31148 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9; E coli polA with
S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Acetonitrile, (3,4,5-trimethoxyphenyl)-
| 13338-63-1 |
Acetonitrile, (1,1,3-trimethylbutylamino)-,hydrochloride
| 73663-79-3 |
Acetonitrile, (2,5-xylyl)-
| 16213-85-7 |
m-Acetophenetidide
| 591-33-3 |
o-Acetophenetidide
| 581-08-8 |
p-Acetophenetidide
| 62-44-2 |
Acetohydroxamic acid, N-(4'-fluoro-4-biphenylyl)-
| 76299-95-1 |
Acetohydroxamic acid, N-(2-naphthyl)-
| 2508-23-8 |
p-Acetophenetidide, 3'-acetyl-beta-methoxy-
| 670-64-4 |
p-Acetophenetidide, 3'-(bis(2-hydroxyethyl)amino)-
| 21615-29-2 |
m-Acetophenetidide,2-(p-butoxyphenoxy)-N-(2-(diethylamino)ethyl)-,monohydrochloride
| 27471-62-1 |
p-Acetophenetidide, 2-(butylamino)-, hydrochloride
| 77966-25-7 |
m-Acetophenetidide, 2-chloro-
| 17641-12-2 |
p-Acetophenetidide, 2-chloro-
| 2153-08-4 |
o-Acetophenetidide, 2-(diethylamino)-, hydrochloride
| 77966-26-8 |
p-Acetophenetidide, 2-(diethylamino)-, hydrochloride
| 77966-27-9 |
p-Acetophenetidide, N-(diethylcarbamoylmethyl)-
| 97555-47-0 |
p-Acetophenetidide,2-dimethylamino-N-(dimethylcarbamoylmethyl)-
| 89169-47-1 |
Acetohydroxamic acid, 2-(p-nitrobenzamido)-
| 39735-49-4 |
p-Acetophenetidide, N-(2-(dimethylamino)ethyl)-,fumarate
| 39735-49-4 |
p-Acetophenetidide, 2-(dimethylamino)-, hydrochloride
| 39735-49-4 |
p-Acetophenetidide,N-(2-(dimethylamino)-1-methylethyl)-, salicylate
| 39735-49-4 |
p-Acetophenetidide, N-(3-(dimethylamino)propyl)-,fumarate
| 39735-49-4 |
p-Acetophenetidide, N-(1-dimethylcarbamoylethyl)-
| 97441-73-1 |
o-Acetophenetidide, N-(dimethylcarbamoylmethyl)-
| 97214-80-7 |
p-Acetophenetidide, N-((dimethylcarbamoyl)methyl)-
| 3736-41-2 |
p-Acetophenetidide, N-ethyl-
| 66922-67-6 |
m-Acetophenetidide, 2-iodo-
| 17641-14-4 |
p-Acetophenetidide, 2-iodo-
| 17641-13-3 |
Acetohydroxamic acid, (p-tert-pentyl)phenyl-
| 63884-95-7 |
p-Acetophenetidide, 2'-isopropyl-5'-methyl-
| 63884-95-7 |
p-Acetophenetidide, 5'-isopropyl-2'-methyl-
| 63884-95-7 |
p-Acetophenetidide, N-methyl-
| 7298-73-9 |
p-Acetophenetidide, 3-nitro-
| 1777-84-0 |
p-Acetophenetidide, 2'-nitro-N-nitroso-
| 15862-16-5 |
p-Acetophenetidide, N-nitroso-
| 15862-11-0 |
p-Acetophenetidide, 2-piperidino-, hydrochloride
| 73693-97-7 |
p-Acetophenetidide, 2-pyrrolidinyl-, hydrochloride
| 77966-28-0 |
p-Acetophenetidide, 2,2,2-trifluoro-
| 457-53-4 |
Acetophenone
| 98-86-2 |
Acetohydroxamic acid, (p-pentylthio)phenyl-
| 63884-96-8 |
Acetophenone, p-acetamido-, 1-thiosemicarbazone
| 7441-55-6 |
Acetophenone, 4'-(9-acridinylamino)-
| 73655-62-6 |
Acetophenone, 4'-(allyloxy)-
| 2079-53-0 |
Acetophenone, 4-allyloxy-3,5-dimethoxy-
| 66922-68-7 |
Acetophenone, 4'-(allyloxy)-, oxime
| 66922-68-7 |
Acetophenone, 4-(5-amidinofuryl)-, monohydrochloride
| 57667-28-4 |
Acetophenone, 4'-(amidinoguanidino)-,amidinohydrazone, dihydrochloride
| 57667-28-4 |
Acetophenone, p-amino-
| 99-92-3 |
Acetophenone, 2-amino-
| 613-89-8 |
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