* Arteannuin
* Artemisia annua L., extract
* Artemisine
* Artemisinin
* Huanghuahaosu
* Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin
-10(3H)-one
* Qinghaosu
* Qing Hau Sau
* Qing Hau SU
* Qinghosu
*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : KD4170000
CHEMICAL NAME : 3,12-Epoxy-12H-pyranol(4,3-j)-1,2-benzodioxepin-10(3H
)-one, octahydro-3,6,9-trimethyl-, (3-
alpha,5a-beta,6-beta,8a-beta,9-alpha,12-beta,12aR*)-(
+)-
CAS REGISTRY NUMBER : 63968-64-9
BEILSTEIN REFERENCE NO. : 4194670
LAST UPDATED : 199612
DATA ITEMS CITED : 9
MOLECULAR FORMULA : C15-H22-O5
MOLECULAR WEIGHT : 282.37
COMPOUND DESCRIPTOR : Drug
Natural Product
SYNONYMS/TRADE NAMES :
* Arteannuin
* Artemisia annua L., extract
* Artemisine
* Artemisinin
* Huanghuahaosu
* Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin
-10(3H)-one
* Qinghaosu
* Qing Hau Sau
* Qing Hau SU
* Qinghosu
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5576 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - tremor
Behavioral - ataxia
REFERENCE :
JTCMEC Journal of Traditional Chinese Medicine (English Edition). (All-China
Assoc. of Traditional Chinese Medicine, Academy of Traditional Chinese
Medicine) V.1- 1981- Volume(issue)/page/year: 2,31,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2571 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - tremor
Behavioral - ataxia
REFERENCE :
JTCMEC Journal of Traditional Chinese Medicine (English Edition). (All-China
Assoc. of Traditional Chinese Medicine, Academy of Traditional Chinese
Medicine) V.1- 1981- Volume(issue)/page/year: 2,31,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4228 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - tremor
Behavioral - ataxia
REFERENCE :
JTCMEC Journal of Traditional Chinese Medicine (English Edition). (All-China
Assoc. of Traditional Chinese Medicine, Academy of Traditional Chinese
Medicine) V.1- 1981- Volume(issue)/page/year: 2,31,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1558 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CMJODS Chinese Medical Journal (Beijing, English Edition). (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1-
1975- Adopted vol. no. 92 in 1979. Volume(issue)/page/year:
92,811,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CMJODS Chinese Medical Journal (Beijing, English Edition). (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1-
1975- Adopted vol. no. 92 in 1979. Volume(issue)/page/year:
92,811,1979
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for
Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972-
Volume(issue)/page/year: 37,1108,1993
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : >800 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JTCMEC Journal of Traditional Chinese Medicine (English Edition). (All-China
Assoc. of Traditional Chinese Medicine, Academy of Traditional Chinese
Medicine) V.1- 1981- Volume(issue)/page/year: 2,31,1982
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 3200 mg/kg/4D-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11-
1980- Volume(issue)/page/year: 21,134,1990
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 1344 mg/kg/14D-I
TOXIC EFFECTS :
Cardiac - other changes
Blood - changes in bone marrow (not otherwise specified)
Blood - other changes
REFERENCE :
JTCMEC Journal of Traditional Chinese Medicine (English Edition). (All-China
Assoc. of Traditional Chinese Medicine, Academy of Traditional Chinese
Medicine) V.1- 1981- Volume(issue)/page/year: 2,31,1982
*** END OF RECORD ***
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