MSDS   | : | Glutamic acid,
N-(p-(((2-amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridi
nyl)methyl)amino) benzoyl)-, L-
| CAS   | : | 135-16-0 | SYNONYMS   | : | * Tetrahydrofolic acid
* 5,6,7,8-Tetrahydrofolic acid
* Tetrahydropteroylglutamic acid
|
| |
|
|
*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : MA0600800
CHEMICAL NAME : Glutamic acid,
N-(p-(((2-amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridi
nyl)methyl)amino) benzoyl)-, L-
CAS REGISTRY NUMBER : 135-16-0
LAST UPDATED : 199707
DATA ITEMS CITED : 5
MOLECULAR FORMULA : C19-H23-N7-O6
MOLECULAR WEIGHT : 445.49
COMPOUND DESCRIPTOR : Reproductive Effector
SYNONYMS/TRADE NAMES :
* Tetrahydrofolic acid
* 5,6,7,8-Tetrahydrofolic acid
* Tetrahydropteroylglutamic acid
*** HEALTH HAZARD DATA ***
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 18 gm/kg/5W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Blood - normocytic anemia
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 7,1104,1973
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 6 gm/kg/6D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - changes in bladder weight
Related to Chronic Data - death
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 7,1128,1973
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 46800 mg/kg/26W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 7,1114,1973
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 70 mg/kg
SEX/DURATION : female 8-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - physical
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 7,1132,1973
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE : 70 mg/kg
SEX/DURATION : female 7-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 7,1132,1973
*** END OF RECORD ***
|
|
|
ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Glucosylamine, N-(6-butoxy-3-pyridyl)-
| 554-18-7 |
beta-D-Glucosylamine, N-methyl-N-nitroso-
| 31364-55-3 |
alpha-D-Glucopyranoside,beta-D-fructofuranosyl-O-alpha-D-galactopyranosyl-(1-6)-, hexadecanoate
| 31364-55-3 |
Glucothiose
| 31364-55-3 |
Glucuronamide
| 3789-97-7 |
D-Glucuronamide, N-(4-(aminosulfonyl)phenyl)-
| 3789-97-7 |
Glucuronic acid, O-(4-biphenylylamino)-
| 3789-97-7 |
Glucuronic acid, O-(2-fluorenylamino)-
| 3789-97-7 |
Glucuronic acid, gamma-lactone, D-
| 32449-92-6 |
Glucuronic acid, gamma-lactone,1-(isonicotinoylhydrazone), D-
| 3691-74-5 |
D-Glucuronic acid, compd. with5-methyl-6-(((3,4,5-trimethoxyphenyl)amino)methyl)-2,4- quinazolinediamine (1:1)
| 82952-64-5 |
Glucuronic acid, monosodium salt
| 7182-77-6 |
Glucuronidase, beta-
| 9001-45-0 |
alpha-D-Glucopyranoside,beta-D-fructofuranosyl-O-alpha-D-galactopyranosyl-(1-6)-, octadecanoate
| 9001-45-0 |
Glutaconic acid, 3-hydroxy-, dimethyl ester, diethylphosphate
| 50708-20-8 |
Glutaconic acid, 3-hydroxy-, dimethyl ester, dimethylphosphate
| 122-10-1 |
Glutaconic acid, 3-hydroxy-, dimethyl ester, dimethylphosphate, (E)-
| 15272-77-2 |
Glutaconic acid, 3-hydroxy-, dimethyl ester, dimethylphosphate, (Z)-
| 15272-78-3 |
Glutaconic acid, 3-hydroxy-, dimethyl ester, O-esterwith O,O-dimethylphosphorothioate, (E)-
| 21395-86-8 |
Glutaconimide, 2-amino-4-ethyl-4-phenyl-
| 14387-60-1 |
Glutaconimide, 4-ethyl-2-hydroxy-4-phenyl-
| 14387-62-3 |
Glutaconimide, 4-ethyl-2-methoxy-N-methyl-4-phenyl-
| 56392-81-5 |
L-Glutamamide,L-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl-N-(((1-carboxy-3-methylbutyl) amino)carbonyl)glycyl-N(sup1)-(1-methyl-2-oxoethyl)-, stereoisomer
| 51798-45-9 |
L-Glutamamide, N(sup2)-(3-hydroxy-1-oxododecyl)-L-asparaginyl-N(sup1)-(1-(dimethoxymethyl)- 3-methylbutyl)-
| 125850-33-1 |
alpha-D-Glucopyranoside,beta-D-fructofuranosyl-O-alpha-D-galactopyranosyl-(1-6)-, (Z)-9-octadecenoate
| 96352-58-8 |
L-Glutamamide, N(sup2)-(3-hydroxy-1-oxododecyl)-L-asparaginyl-N(sup1)-(1-formyl-3- methylbutyl)-
| 125882-62-4 |
Glutamic acid, DL-
| 617-65-2 |
Glutamic acid, L-
| 56-86-0 |
L-Glutamic acid, N-acetyl-
| 1188-37-0 |
L-Glutamic acid,N-(3-(2-(4-(acetylamino)-1-oxobutyl)-5-chlorophenyl)-1-oxopropyl)-, diethyl ester
| 122186-90-7 |
Glycine,N-(3-(2-(4-(acetylamino)-1-oxobutyl)-5-chlorophenyl)-1-oxopropyl)-, ethyl ester
| 122186-87-2 |
DL-Glutamic acid, N-acetyl-,bis(2-(dimethoxyphosphinyl)ethyl)ester
| 152819-37-9 |
Glycine,N-((2-acetyl-7-butoxy-4-benzofuranyl)sulfonyl)-N-methyl-
| 105642-02-2 |
Glycine,N-((2-acetyl-7-((4-chlorophenyl)methoxy)-4-benzofuranyl)sulfonyl)-N-((4- chlorophenyl)methyl)-
| 105627-73-4 |
Glutamic acid, N-acetyl-, compd. with2-(dimethylamino)ethanol (1:1), L-
| 3342-61-8 |
alpha-D-Glucopyranoside,beta-D-fructofuranosyl-O-alpha-D-galactopyranosyl-(1-6)-, tetradecanoate
| 3342-61-8 |
Glutamic acid, N-acetyl-, compd. with2-(dimethylamino)ethanol (1:2), L-
| 3342-61-8 |
Glutamic acid, N-acetyl-, L-, compd. with L-lysine
| 24577-75-1 |
L-Glutamic acid, N-(aminocarbonyl)-
| 1188-38-1 |
L-Glutamic acid,N-(4-(((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-, mixed with L-cysteine
| 8064-47-9 |
L-Glutamic acid,N-(4-(((2-amino-1,4-dihydro-4-oxo-6-quinazolinyl)methyl)-2-propynylamino) benzoyl)-
| 76849-19-9 |
Glutamic acid,N-(p-(((2-amino-5-formyl-5,6,7,8-tetrahydro-3-hydroxy-6-pteridinyl)methyl) amino)benzoyl)-, calcium salt(1:1), L-
| 1492-18-8 |
Glutamic acid,N-(p-(((2-amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino) benzoyl)-, L-
| 135-16-0 |
L-Glutamic acid,N-(N-(4-(((2-amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)formylamino)benzoyl)-L-gamma-glutamyl)-, hydrate(1:5)
| 29552-62-3 |
L-Glutamic acid,N-(4-(2-(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-d)pyrimidin-6-yl) ethyl)benzoyl)-
| 95693-76-8 |
Glutamic acid,N-(p-((2-(2-amino-4-hydroxy-6-pteridinyl)ethyl)amino)benzoyl)-
| 3566-25-4 |
beta-D-Glucopyranoside,1a,1b,2,5a,6,6a-hexahydro-6-((4-hydroxybenzoyl)oxy)-1a-(hydroxymethyl)oxireno(4,5)cyclopenta(1,2-c)pyran-2-yl, (1aS-(1a-alpha,1b-beta,2-beta,5a-beta,6-beta,6a-alpha))-
| 6736-85-2 |
Glutamic acid,N-(p-((1-(2-amino-4-hydroxy-6-pteridinyl)ethyl)amino)benzoyl)- L-
| 2179-16-0 |
Glutamic acid,N-(p-(((2-amino-4-hydroxy-6-pteridyl)methyl)methylamino)benzoyl)-
| 2410-93-7 |
L-Glutamic acid,N-(1,5-anhydro-2,4-dideoxy-3-C-methyl-L-threo-pentitol-2-yl)-
| 134309-96-9 |
|
|