D-Glucuronic acid, compd. with
5-methyl-6-(((3,4,5-trimethoxyphenyl)amino)methyl)-2,
4- quinazolinediamine (1:1)
CAS  
:
82952-64-5
SYNONYMS  
:
* CI 898
* 6-(((3,4,5-Trimethoxyphenyl)amino)methyl)-5-methyl-2,4-quinazolinediamine
glucuronate
* Trimetrexate glucuronate
*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : LZ8945000
CHEMICAL NAME : D-Glucuronic acid, compd. with
5-methyl-6-(((3,4,5-trimethoxyphenyl)amino)methyl)-2,
4- quinazolinediamine (1:1)
CAS REGISTRY NUMBER : 82952-64-5
LAST UPDATED : 199412
DATA ITEMS CITED : 5
MOLECULAR FORMULA : C19-H23-N5-O3.C6-H10-O7
MOLECULAR WEIGHT : 563.63
COMPOUND DESCRIPTOR : Drug
Mutagen
Human
SYNONYMS/TRADE NAMES :
* CI 898
* 6-(((3,4,5-Trimethoxyphenyl)amino)methyl)-5-methyl-2,4-quinazolinediamine
glucuronate
* Trimetrexate glucuronate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Human
DOSE/DURATION : 2027 ug/kg
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section
Gastrointestinal - other changes
Blood - thrombocytopenia
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
47,3303,1987
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Human
DOSE/DURATION : 4054 mg/kg/3W-I
TOXIC EFFECTS :
Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
47,3303,1987
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
18,115,1992
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 50 mg/kg/5D-C
TOXIC EFFECTS :
Blood - changes in leukocyte (WBC) count
Blood - changes in platelet count
Related to Chronic Data - changes in testicular weight
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
18,115,1992
** MUTATION DATA **
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - mouse Leukocyte
DOSE/DURATION : 500 nmol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
40,1981,1990
*** END OF RECORD ***
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