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MSDS  : Acridine, 6-chloro-9-(3-(N-(2-chloroethyl)-N-ethylamino)propyla mino)-2-methoxy-, dihydrochloride
CAS  : 146-59-8
SYNONYMS  : * Acridine mustard * 6-Chloro-9-(3-(ethyl-2-chloroethyl)aminopropylamino)-2-methoxyacridine dihydrochloride * 9-(3-(Ethyl(2-chloroethyl)amino)propylamino)-6-chloro-2-methoxyacridine dihydrochloride * ICR 170 * 1,3-Propanediamine, N-(2-chloroethyl)-N'-(6-chloro-2-methoxy-9-acridinyl)-N-ethyl-, 2HCl
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : AR7680000
CHEMICAL NAME : Acridine,
6-chloro-9-(3-(N-(2-chloroethyl)-N-ethylamino)propyla
mino)-2-methoxy-, dihydrochloride
CAS REGISTRY NUMBER : 146-59-8
LAST UPDATED : 199710
DATA ITEMS CITED : 47
MOLECULAR FORMULA : C21-H25-Cl2-N3-O.2Cl-H
MOLECULAR WEIGHT : 479.31
WISWESSER LINE NOTATION : T C666 BNJ EG IM3N2&2G LO1 &GH &GH
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Acridine mustard
* 6-Chloro-9-(3-(ethyl-2-chloroethyl)aminopropylamino)-2-methoxyacridine
dihydrochloride
* 9-(3-(Ethyl(2-chloroethyl)amino)propylamino)-6-chloro-2-methoxyacridine
dihydrochloride
* ICR 170
* 1,3-Propanediamine,
N-(2-chloroethyl)-N'-(6-chloro-2-methoxy-9-acridinyl)-N-ethyl-, 2HCl

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD20 - Lethal Dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 15,739,1972

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 5 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
36,2423,1976

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4800 ug/kg/28D-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
36,2423,1976

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 4 mg/kg
SEX/DURATION : female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 13,171,1971

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 500 ng/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 136,185,1984

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 10 ug/plate
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.1- 1915-
Volume(issue)/page/year: 72,5135,1975

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 5 mg/L
REFERENCE :
JMOBAK Journal of Molecular Biology. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 46,1,1969

TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 3 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 203,81,1988

TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 230 ng/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 133,161,1984

TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 60 ng/plate
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
43,2819,1983

TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 60 ug/disc
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 97,1,1982

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 25 mg/L
REFERENCE :
GENRA8 Genetical Research. (Cambridge Univ. Press, 32 E. 57th St., New
York, NY 10022) V.1- 1960- Volume(issue)/page/year: 13,57,1969

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 10 mg/L
REFERENCE :
GENRA8 Genetical Research. (Cambridge Univ. Press, 32 E. 57th St., New
York, NY 10022) V.1- 1960- Volume(issue)/page/year: 29,65,1977

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 3700 nmol/L
REFERENCE :
GENTAE Genetics. (Genetics Business Office, POB 64025, Baltimore, MD 21264)
V.1- 1916- Volume(issue)/page/year: 90,1,1978

TYPE OF TEST : Specific locus test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 20860 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 6,153,1984

TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 2100 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
30,195,1970

TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Multiple routes
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 200 mg/L
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.1- 1945- Volume(issue)/page/year: 23,266,1967

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Mold - Neurospora crassa
DOSE/DURATION : 12 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 53,297,1978

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 5 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 10,11,1970

TYPE OF TEST : Gene conversion and mitotic recombination
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 500 umol/L
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp.,
233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year:
17,915,1981

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Mold - Aspergillus nidulans
DOSE/DURATION : 270 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 8,255,1969

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Yeast - Schizosaccharomyces pombe
DOSE/DURATION : 5 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 9,199,1970

TYPE OF TEST : DNA repair
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 1 umol/L/1H (Continuous)
REFERENCE :
36YFAG "Biological Reactive Intermediates, Formation, Toxicity and
Inactivation, Proceedings of the International Conference, Turku, Finland,
1975," Jollow, D.J., et al., eds., New York, Plenum Pub. Corp., 1977
Volume(issue)/page/year: -,483,1977

TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 1 umol/L/1H
REFERENCE :
33AQAA "Biology of Radiation Carcinogenesis, Symposium, 1975," Yuhas, J.M.,
et al., eds., New York, Raven Press, 1976 Volume(issue)/page/year:
-,103,1976

TYPE OF TEST : DNA inhibition
TEST SYSTEM : Human HeLa cell
DOSE/DURATION : 50 nmol/L/30M (Continuous)
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest
South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
Volume(issue)/page/year: 2(1),65,1978

TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 800 ug/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.1- 1915-
Volume(issue)/page/year: 75,3337,1978

TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 10 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 3,11,1981

TYPE OF TEST : Micronucleus test
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 100 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 222,191,1989

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 10 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 222,191,1989

TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 50 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 222,191,1989

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 30 nmol/L
REFERENCE :
MOTOEX Molecular Toxicology. (Taylor & Francis, Inc., 242 Cherry St.,
Philadelphia, PA USA 19106) V.1- 1987- Volume(issue)/page/year:
1,217,1987

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 100 ug/L
REFERENCE :
CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San
Francisco, CA 94103) V.1- 1929- Volume(issue)/page/year: 54,149,1989

TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 100 ug/L
REFERENCE :
CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San
Francisco, CA 94103) V.1- 1929- Volume(issue)/page/year: 54,149,1989

TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 700 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 151,293,1985

TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 100 ug/L
REFERENCE :
CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San
Francisco, CA 94103) V.1- 1929- Volume(issue)/page/year: 54,149,1989

TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Mammal - species unspecified Lymphocyte
DOSE/DURATION : 1 umol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
8,113,1974

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Positive: N crassa-forward mutation; N
crassa-reversion

EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test

EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal

EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation

EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion

EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-forward mutation; S
cerevisiae-homozygosis

EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-reversion

EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat

EPA GENETOX PROGRAM 1988, Inconclusive: Rodent dominant lethal; Mouse
specific locus

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
4-Acridinecarboxamide,9,9'-tetramethylenebis(sulfonylimino)bis(2-methoxy-p-phenyleneimino) bis-, dihydrochloride, sesquihydrate 113106-31-3
Acridan,9-methoxy-9-((4-methyl-1-piperazinyl)methyl)- 16299-13-1
4-Acridinecarboxamide,9,9'-tetramethylenedioxybis(4-methylsulfonamido-o-phenyleneimino) bis-, dihydrochloride, dihydrate 66724-96-7
3-Acridinecarboxamidine, 9-amino-7-methoxy-,monohydrochloride 66724-96-7
2-Acridinecarboxamidine, 9-amino-, monohydrochloride 66724-96-7
3-Acridinecarboxamidine, 9-amino-, monohydrochloride 66724-96-7
3-Acridinecarboxamidoxime, 9-amino- 66724-96-7
3-Acridinecarboxamidoxime, 9-amino-7-methoxy- 66724-96-7
2-Acridinecarboxylic acid 54328-73-3
2-Acridinecarboxylic acid, 9-amino- 64046-80-6
2-Acridinecarboxylic acid, 9-amino-, methyl ester 64046-78-2
Acridine-10(9H)-carboxylic acid,2-(diethylamino)ethyl ester, ethanedioate (1:1) 64046-78-2
9-Acridanone, 3-methoxy-4-(morpholinomethyl)- 58324-16-6
Acridine-9-carboxylic acid, 2-(diethylamino)ethylester, hydrochloride 64046-81-7
4-Acridinecarboxylic acid,9-((3-(dimethylamino)propyl)amino)-1-nitro-, methylester 116374-64-2
9-Acridinecarboxylic acid, methyl ester 5132-81-0
Acridine, 9-(p-chloroanilino)- 61462-75-7
Acridine, 9-(o-chloroanilino)-, hydrochloride 14408-86-7
Acridine, 9-(m-chloroanilino)-, methanesulfonate 75775-66-5
Acridine,6-chloro-9-(3-((2-chloroethyl)amino)propyl)amino-2-methoxy-, dihydrochloride 17070-45-0
Acridine,6-chloro-9-(3-(N-(2-chloroethyl)-N-ethylamino)propylamino)-2-methoxy-, dihydrochloride 146-59-8
Acridine,6-chloro-9-((3-((2-chloroethyl)thio)propyl)amino)-2-methoxy-, hydrochloride 99711-15-6
Acridine,6-chloro-9-((4-(diethylamino)butyl)amino)-2-methoxy-,dihydrochloride 6286-97-1
9-Acridanone, 3-methoxy-4-(piperidinomethyl)- 58324-15-5
Acridine,3-chloro-9-(4-(diethylamino)-1-(4-methoxyphenyl)butylamino)-7-methoxy-, dihydrochloride, hydrate 73680-44-1
Acridine,6-chloro-9-((4-(diethylamino)-1-methyl-2-butenyl)amino)-2-methoxy-, dihydrochloride, (E)- 40961-63-5
Acridine,6-chloro-9-((4-(diethylamino)-1-methyl-2-butenyl)amino)-2-methoxy-, dihydrochloride, (Z)- 40961-62-4
Acridine,6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxy- 83-89-6
Acridine,6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxy-, DL- 66777-81-9
Acridine,6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxy-, dihydrochloride 69-05-6
Acridine,6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxy-, dihydrochloride, dihydrate 6151-30-0
Acridine,6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxy-, dimethanesulfonate 316-05-2
Acridine,6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxy-, compd. with sodium nitrite (1:3) 316-05-2
Acridine,2-chloro-5-((4-dimethylamino-1-methylbutyl)amino)-7-methoxy- 64046-82-8
9-Acridanone, 3-methoxy-4-(1-pyrrolidinyl)methyl- 58324-14-4
Acridine,9-(2-((2-chloroethyl)amino)ethylamino)-6-chloro-2-methoxy-, dihydrochloride, hydrate 10072-24-9
Acridine,9-(3-(N-(2-chloroethyl)-N-ethylamino)propylamino)-4-methoxy-, dihydrochloride 38915-14-9
Acridine,3-chloro-9-(4-hydroxy-3-piperidinomethylanilino)-7-methoxy-, 10-oxide 73663-84-0
Acridine, 2-chloro-9-(4-quinazolinylthio)- 102244-08-6
Acridine, 9-cyclohexylamino- 64046-83-9
Acridine, 9,9'-(decamethylenediimino)bis- 21988-21-6
Acridine,9,9'-decamethylenedioxybis(o-phenyleneimino)bis-,dihydrochloride 66724-94-5
4,9-Acridinediamine, N(sup 4),N(sup 4)-dimethyl-N(sup9)-(3-(dimethylamino)propyl)-1-nitro- 116374-67-5
Acridine, 1,9-diamino- 23043-60-9
Acridine, 2,7-diamino- 23043-63-2
Acridan, 2-chloro-9-(3-(dimethylamino)propyl)-,phosphate (1:1) 22199-46-8
9-Acridanone, 6-methoxy-10-(p-tolylsulfonyl)- 102207-87-4
Acridine, 2,9-diamino- 23043-62-1
Acridine, 3,5-diamino- 40505-25-7
Acridine, 3,6-diamino- 92-62-6

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