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MSDS  : Acridine, 6-chloro-9-(3-((2-chloroethyl)amino)propyl)amino-2-me thoxy-, dihydrochloride
CAS  : 17070-45-0
SYNONYMS  : * ICR-191 * ICR-191A * ICR dihydrochloride * 2-Methoxy-6-chloro-9-(3-(2-chloroethyl)aminopropylamino) acridine, dihydrochloride * 1,3-Propanediamine, N-(2-chloroethyl)-N'-(6-chloro-2-methoxy-9-acridinyl)-, dihydrochloride
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : AR7678000
CHEMICAL NAME : Acridine,
6-chloro-9-(3-((2-chloroethyl)amino)propyl)amino-2-me
thoxy-, dihydrochloride
CAS REGISTRY NUMBER : 17070-45-0
LAST UPDATED : 199410
DATA ITEMS CITED : 41
MOLECULAR FORMULA : C19-H21-Cl2-N3-O.2Cl-H
MOLECULAR WEIGHT : 451.25
WISWESSER LINE NOTATION : T C666 BNJ EG IM3M2G LO1 &GH 2
COMPOUND DESCRIPTOR : Mutagen
SYNONYMS/TRADE NAMES :
* ICR-191
* ICR-191A
* ICR dihydrochloride
* 2-Methoxy-6-chloro-9-(3-(2-chloroethyl)aminopropylamino) acridine,
dihydrochloride
* 1,3-Propanediamine,
N-(2-chloroethyl)-N'-(6-chloro-2-methoxy-9-acridinyl)-, dihydrochloride

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD20 - Lethal Dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 41 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 15,739,1972

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 320 ng/plate
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
16,204,1990

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 500 ng/plate
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.1- 1915-
Volume(issue)/page/year: 72,5135,1975

TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 220 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 192,239,1987

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 93 umol/L
REFERENCE :
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl.
3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967-
Volume(issue)/page/year: 195,418,1984

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 400 ng/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 151,49,1985

TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 700 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 203,81,1988

TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 160 ng/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 158,19,1985

TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 300 ng/plate
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
43,2819,1983

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 38,271,1976

TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 125 ug/disc
REFERENCE :
AEMIDF Applied and Environmental Microbiology. (American Soc. for
Microbiology, 1913 I St., NW, Washington, DC 20006) V.31- 1976-
Volume(issue)/page/year: 43,177,1982

TYPE OF TEST : DNA damage
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 42,175,1977

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Serratia marcescens
DOSE/DURATION : 1 gm/L
REFERENCE :
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74.
For publisher information, see ARTODN. Volume(issue)/page/year: 28,93,1971

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Haemophilus influenzae
DOSE/DURATION : 90900 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 80,239,1981

TYPE OF TEST : DNA inhibition
TEST SYSTEM : Bacteria - Haemophilus influenzae
DOSE/DURATION : 250 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 80,249,1981

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 25 mg/L
REFERENCE :
GENRA8 Genetical Research. (Cambridge Univ. Press, 32 E. 57th St., New
York, NY 10022) V.1- 1960- Volume(issue)/page/year: 13,57,1969

TYPE OF TEST : DNA damage
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 2 umol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
22,46,1993

TYPE OF TEST : Gene conversion and mitotic recombination
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 10 umol/L
REFERENCE :
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser
Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70-
Volume(issue)/page/year: 3,99,1973

TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 1 umol/L/3H
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
Volume(issue)/page/year: 16,284,1975

TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 4 mg/L/24H
REFERENCE :
IMNGBK Immunogenetics. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.1- 1974- Volume(issue)/page/year:
4,437,1977

TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 300 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 125,95,1984

TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 10 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 3,11,1981

TYPE OF TEST : Micronucleus test
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 50 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 222,191,1989

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Rodent - mouse Bone marrow
DOSE/DURATION : 250 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 81,215,1981

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 2 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 95,297,1982

TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - mouse Embryo
DOSE/DURATION : 580 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 152,113,1985

TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - mouse Testis
DOSE/DURATION : 500 nmol/L/5H
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
37,195,1977

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 250 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 222,191,1989

TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Liver
DOSE/DURATION : 500 ug/L
REFERENCE :
SCGTDW Somatic Cell Genetics. (New York, NY) V.1-9, 1975-83. For
publisher information, see SCMGDN. Volume(issue)/page/year: 7,373,1981

TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Leukocyte
DOSE/DURATION : 2200 nmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
42,956,1982

TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 2200 nmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
42,956,1982

TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION : 2400 ug/L
REFERENCE :
43VMAC "Microsomes, Drug Oxidations, and Chemical Carcinogenesis,
International Symposium on Microsomes and Drug Oxidations, 4th, 1979," Coon,
M.J., et al., eds., New York, Academic Press, Inc., 1980
Volume(issue)/page/year: 4,1149,1980

TYPE OF TEST : Host-mediated assay
TEST SYSTEM : Rodent - mouse Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 500 umol/L/kg
REFERENCE :
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser
Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70-
Volume(issue)/page/year: 3,99,1973

TYPE OF TEST : Host-mediated assay
TEST SYSTEM : Rodent - mouse Bacteria - Salmonella typhimurium
DOSE/DURATION : 46 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 156,93,1985

TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 10 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
44,3270,1984

TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 500 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 139,95,1984

TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 1 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
42,817,1982

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Amphibian - frog Embryo
DOSE/DURATION : 1 umol/L
REFERENCE :
JCLLAX Journal of Cellular Physiology. (Alan R. Liss, Inc., 41 E. 11th St.,
New York, NY 10003) V.67- 1966- Volume(issue)/page/year: 94,187,1978

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay; Histidine
reversion-Ames test

EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion

EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
4-Acridinecarboxamide,9,9'-tetramethylenebis(sulfonylimino)bis(2-methoxy-p-phenyleneimino) bis-, dihydrochloride, sesquihydrate 113106-31-3
Acridan,9-methoxy-9-((4-methyl-1-piperazinyl)methyl)- 16299-13-1
4-Acridinecarboxamide,9,9'-tetramethylenedioxybis(4-methylsulfonamido-o-phenyleneimino) bis-, dihydrochloride, dihydrate 66724-96-7
3-Acridinecarboxamidine, 9-amino-7-methoxy-,monohydrochloride 66724-96-7
2-Acridinecarboxamidine, 9-amino-, monohydrochloride 66724-96-7
3-Acridinecarboxamidine, 9-amino-, monohydrochloride 66724-96-7
3-Acridinecarboxamidoxime, 9-amino- 66724-96-7
3-Acridinecarboxamidoxime, 9-amino-7-methoxy- 66724-96-7
2-Acridinecarboxylic acid 54328-73-3
2-Acridinecarboxylic acid, 9-amino- 64046-80-6
2-Acridinecarboxylic acid, 9-amino-, methyl ester 64046-78-2
Acridine-10(9H)-carboxylic acid,2-(diethylamino)ethyl ester, ethanedioate (1:1) 64046-78-2
9-Acridanone, 3-methoxy-4-(morpholinomethyl)- 58324-16-6
Acridine-9-carboxylic acid, 2-(diethylamino)ethylester, hydrochloride 64046-81-7
4-Acridinecarboxylic acid,9-((3-(dimethylamino)propyl)amino)-1-nitro-, methylester 116374-64-2
9-Acridinecarboxylic acid, methyl ester 5132-81-0
Acridine, 9-(p-chloroanilino)- 61462-75-7
Acridine, 9-(o-chloroanilino)-, hydrochloride 14408-86-7
Acridine, 9-(m-chloroanilino)-, methanesulfonate 75775-66-5
Acridine,6-chloro-9-(3-((2-chloroethyl)amino)propyl)amino-2-methoxy-, dihydrochloride 17070-45-0
Acridine,6-chloro-9-(3-(N-(2-chloroethyl)-N-ethylamino)propylamino)-2-methoxy-, dihydrochloride 146-59-8
Acridine,6-chloro-9-((3-((2-chloroethyl)thio)propyl)amino)-2-methoxy-, hydrochloride 99711-15-6
Acridine,6-chloro-9-((4-(diethylamino)butyl)amino)-2-methoxy-,dihydrochloride 6286-97-1
9-Acridanone, 3-methoxy-4-(piperidinomethyl)- 58324-15-5
Acridine,3-chloro-9-(4-(diethylamino)-1-(4-methoxyphenyl)butylamino)-7-methoxy-, dihydrochloride, hydrate 73680-44-1
Acridine,6-chloro-9-((4-(diethylamino)-1-methyl-2-butenyl)amino)-2-methoxy-, dihydrochloride, (E)- 40961-63-5
Acridine,6-chloro-9-((4-(diethylamino)-1-methyl-2-butenyl)amino)-2-methoxy-, dihydrochloride, (Z)- 40961-62-4
Acridine,6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxy- 83-89-6
Acridine,6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxy-, DL- 66777-81-9
Acridine,6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxy-, dihydrochloride 69-05-6
Acridine,6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxy-, dihydrochloride, dihydrate 6151-30-0
Acridine,6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxy-, dimethanesulfonate 316-05-2
Acridine,6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxy-, compd. with sodium nitrite (1:3) 316-05-2
Acridine,2-chloro-5-((4-dimethylamino-1-methylbutyl)amino)-7-methoxy- 64046-82-8
9-Acridanone, 3-methoxy-4-(1-pyrrolidinyl)methyl- 58324-14-4
Acridine,9-(2-((2-chloroethyl)amino)ethylamino)-6-chloro-2-methoxy-, dihydrochloride, hydrate 10072-24-9
Acridine,9-(3-(N-(2-chloroethyl)-N-ethylamino)propylamino)-4-methoxy-, dihydrochloride 38915-14-9
Acridine,3-chloro-9-(4-hydroxy-3-piperidinomethylanilino)-7-methoxy-, 10-oxide 73663-84-0
Acridine, 2-chloro-9-(4-quinazolinylthio)- 102244-08-6
Acridine, 9-cyclohexylamino- 64046-83-9
Acridine, 9,9'-(decamethylenediimino)bis- 21988-21-6
Acridine,9,9'-decamethylenedioxybis(o-phenyleneimino)bis-,dihydrochloride 66724-94-5
4,9-Acridinediamine, N(sup 4),N(sup 4)-dimethyl-N(sup9)-(3-(dimethylamino)propyl)-1-nitro- 116374-67-5
Acridine, 1,9-diamino- 23043-60-9
Acridine, 2,7-diamino- 23043-63-2
Acridan, 2-chloro-9-(3-(dimethylamino)propyl)-,phosphate (1:1) 22199-46-8
9-Acridanone, 6-methoxy-10-(p-tolylsulfonyl)- 102207-87-4
Acridine, 2,9-diamino- 23043-62-1
Acridine, 3,5-diamino- 40505-25-7
Acridine, 3,6-diamino- 92-62-6

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