*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : AR7175000
CHEMICAL NAME : Acridine
CAS REGISTRY NUMBER : 260-94-6
BEILSTEIN REFERENCE NO. : 0120200
REFERENCE : 5-20-08-00199 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 18
MOLECULAR FORMULA : C13-H9-N
MOLECULAR WEIGHT : 179.23
WISWESSER LINE NOTATION : T C666 BNJ
COMPOUND DESCRIPTOR : Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Akridin
* 9-Azaanthracene
* 10-Azaanthracene
* Benzo(b)quinoline
* 2,3-Benzoquinoline
* Coal tar pitch volatiles:acridine
* Dibenzo(b,e)pyridine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - necrotic changes
Blood - changes in erythrocyte (RBC) count
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 14(9),56,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - somnolence (general depressed activity)
Behavioral - excitement
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 14(9),56,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJEPA5 British Journal of Experimental Pathology. (Blackwell Scientific
Pub. Ltd., POB 88, Oxford, UK) V.1- 1920- Volume(issue)/page/year:
28,1,1947
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJEPA5 British Journal of Experimental Pathology. (Blackwell Scientific
Pub. Ltd., POB 88, Oxford, UK) V.1- 1920- Volume(issue)/page/year:
28,1,1947
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4500 mg/kg/45D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Blood - pigmented or nucleated red blood cells
Blood - changes in other cell count (unspecified)
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 14(9),56,1970
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 230 nmol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 3,11,1981
TYPE OF TEST : DNA adduct
TEST SYSTEM : Mammal - species unspecified Lymphocyte
DOSE/DURATION : 100 umol/L
REFERENCE :
JMOBAK Journal of Molecular Biology. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,18,1961
TYPE OF TEST : DNA adduct
TEST SYSTEM : Bird - chicken Leukocyte
DOSE/DURATION : 100 umol/L
REFERENCE :
JMOBAK Journal of Molecular Biology. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,18,1961
*** U.S. STANDARDS AND REGULATIONS ***
OSHA PEL (Gen Indu):8H TWA 0.2 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.2 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.2 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.2 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 03490
No. of Facilities: 17 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 34 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 03490
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 70 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: S cerevisiae-forward mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Acrylic acid, 3-mercapto-, dibutylcarbamate
| 1330-61-6 |
9-Acridinamine,1,2,3,4-tetrahydro-N-(2-methylpropyl)-
| 34811-11-5 |
Acrylic acid, 3-(p-methoxybenzoyl)-
| 34811-11-5 |
Acrylic acid, 3-(o-methoxyphenyl)-2-phenyl- (E)-
| 21140-85-2 |
Acrylic acid, 2-(p-methoxyphenyl)-3-(2-thienyl)-,3-tropanyl ester, hydrochloride
| 66922-77-8 |
Acrylic acid, methylcarbamylethyl ester
| 59163-97-2 |
Acrylic acid, methyl ester
| 96-33-3 |
Acrylic acid, 3-(2-(methyl-aci-nitro)acetamido)-,(E)-
| 3552-16-7 |
Acrylic acid, 2-methylthio-, S-p-chlorophenyl ester
| 3552-16-7 |
Acrylic acid, 2-(methylthio)ethyl ester
| 4836-09-3 |
Acrylic acid, 2-morpholinoethyl ester
| 4836-09-3 |
Acrylic acid, 3-(5-nitro-2-furyl)-, ethyl ester
| 1874-12-0 |
9-Acridinamine,1,2,3,4-tetrahydro-N-(2-methylpropyl)-,monohydrochloride
| 113106-69-7 |
Acrylic acid, 5-norbornen-2-ylmethyl ester
| 95-39-6 |
Acrylic acid, 2-norbornyl ester
| 10027-06-2 |
Acrylic acid, 3-(phenylsulfinyl)-, ethyl ester
| 73663-93-1 |
Acrylic acid, 3-(phenylthio)-, ethyl ester
| 64050-18-6 |
Acrylic acid, polymer with maleic anhydride
| 26677-99-6 |
Acrylic acid, polymers
| 9003-01-4 |
Acrylic acid, polymer with sucrose polyallyl ether
| 9007-16-3 |
Acrylic acid, propylenebis(oxypropylene) ester
| 42978-66-5 |
Acrylic acid, 3-salicyloyl-
| 86416-35-5 |
Acrylic acid, telomer with carbon tetrachloride (14)
| 86416-35-5 |
9-Acridinamine, 1,2,3,4-tetrahydro-N-propyl-,monohydrochloride
| 113106-68-6 |
Acrylic acid,((3a,4,7,7a-tetrahydro)4,7-methanoindenyl) ester
| 50976-02-8 |
Acrylic acid, 2,4,5-trichlorophenyl ester compd. withaziridine
| 101952-47-0 |
Acrylic acid,2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptyl ester
| 559-11-5 |
Acrylic acid, tridecyl ester
| 3076-04-8 |
Acrylic acid, triester with2-ethyl-2-(hydroxymethyl)-1,3-propanediol
| 15625-89-5 |
Acrylic acid, triester with3,3',3''-((1,2,3-propanetriyl)trioxy)tri-1-propanol
| 15625-89-5 |
Acrylic acid, 3-(2,3,4-trimethoxybenzoyl)-, (E)-
| 39901-44-5 |
1',1'-Acrylonaphthone, 3-chloro-
| 25872-02-0 |
Acrylonitrile
| 107-13-1 |
Acrylonitrile, 2,3-bis(p-chlorophenyl)-
| 3695-94-1 |
Acridine
| 260-94-6 |
Acrylonitrile, 2-chloro-
| 920-37-6 |
Acrylonitrile, 2-(chloromethyl)-
| 7659-44-1 |
Acrylonitrile, 3-(p-chlorophenyl)-2-(p-nitrophenyl)-
| 2900-72-3 |
Acrylonitrile, 2-(p-chlorophenyl)-3-phenyl-
| 3695-93-0 |
Acrylonitrile, 3-(p-chlorophenyl)-2-phenyl-
| 3695-92-9 |
Acrylonitrile, 2,3-dichloro-
| 22410-58-8 |
Acrylonitrile, 3,3-dicyclopropyl-2-(ethoxycarbonyl)-
| 5232-99-5 |
Acrylonitrile, 2,3-diphenyl-
| 2510-95-4 |
Acrylonitrile, 3-ethoxy-
| 61310-53-0 |
Acrylonitrile, 2-(p-methoxyphenyl)-3,3-diphenyl-
| 16143-89-8 |
10(9H)-Acridineacetamide,N-(3-(dimethylamino)propyl)-9-oxo-, monohydrochloride
| 77778-92-8 |
Acrylonitrile, 2-nitro-3-(5-nitrofurfuryl)-
| 77778-92-8 |
Acrylonitrile, 2-(p-nitrophenyl)-3-phenyl-
| 3695-95-2 |
Acrylonitrile, polymer with 1,3-butadiene and styrene
| 9003-56-9 |
Acrylonitrile, polymer with 1,3-butadiene, andstyrene, combustion products
| 9003-56-9 |
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