RTECS NUMBER : MI7601180
CHEMICAL NAME : Heptanamide,
7-((aminoiminomethyl)amino)-N-(2-((4-((3-aminopropyl)
amino)butyl)amino)- 1-hydroxy-2-oxoethyl)-,
trihydrochloride, dihydrate
CAS REGISTRY NUMBER : 85468-01-5
LAST UPDATED : 199206
DATA ITEMS CITED : 4
MOLECULAR FORMULA : C17-H37-N7-O3.3Cl-H.2H2-O
MOLECULAR WEIGHT : 531.01
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* 1-Amino-19-guanidino-11-hydroxy-4,9,12-triazononadecane-10,13-dione
trihydrochloride 2H2O
* (-)-15-Deoxyspergualine trihydrochloride dihydrate
* NKT-01 trihydrochloride dihydrate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 35 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8
Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968-
Volume(issue)/page/year: 35,1665,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 35 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8
Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968-
Volume(issue)/page/year: 35,1665,1982
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 61 mg/kg/13W-C
TOXIC EFFECTS :
Endocrine - other changes
Endocrine - changes in thymus weight
Blood - normocytic anemia
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 25,927,1991
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 27300 ug/kg/13W-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 25,2954,1991
*** END OF RECORD ***
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