*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : NI2922170
CHEMICAL NAME : 4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic
acid, 8-fluoro-5,6-dihydro-5-methyl-6- oxo-, ethyl
ester
CAS REGISTRY NUMBER : 78755-81-4
BEILSTEIN REFERENCE NO. : 4763661
LAST UPDATED : 199612
DATA ITEMS CITED : 15
MOLECULAR FORMULA : C15-H14-F-N3-O3
MOLECULAR WEIGHT : 303.32
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Anexate
* Ethyl
8-fluoro-5-methyl-5,6-dihydro-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine
-3-carboxylate
* Flumazenil
* Flumazepil
* Lanexat
* Ro-15-1788
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Human - man
DOSE/DURATION : 5700 ng/kg/C
TOXIC EFFECTS :
Cardiac - cardiomyopathy including infarction
Cardiac - arrhythmias (including changes in conduction)
Cardiac - change in rate
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
304,1415,1992
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 2 mg/kg/2D-I
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
Behavioral - excitement
Behavioral - aggression
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 339,488,1992
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 4 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Cardiac - EKG changes not diagnostic of specified effects
Cardiac - pulse rate increase, without fall in BP
REFERENCE :
PECAE5 Pediatric Emergency Care. (Williams & Wilkins, 428 E. Preston St.,
Baltimore, MD 21202) V.1- 1985- Volume(issue)/page/year: 11,186,1995
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4200 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Behavioral - rigidity (including catalepsy)
REFERENCE :
JTCEEM Journal de Toxicologie Clinique et Experimentale. (SPPIF, B.P.22,
F-41353 Vineuil, France) V.5- 1985- Volume(issue)/page/year: 7,223,1987
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1360 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540,
08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year:
7,402,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 85 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - rigidity (including catalepsy)
REFERENCE :
JTCEEM Journal de Toxicologie Clinique et Experimentale. (SPPIF, B.P.22,
F-41353 Vineuil, France) V.5- 1985- Volume(issue)/page/year: 7,223,1987
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1300 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Behavioral - rigidity (including catalepsy)
REFERENCE :
JTCEEM Journal de Toxicologie Clinique et Experimentale. (SPPIF, B.P.22,
F-41353 Vineuil, France) V.5- 1985- Volume(issue)/page/year: 7,223,1987
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540,
08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year:
7,402,1982
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 23,201,1992
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 143 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - rigidity (including catalepsy)
REFERENCE :
JTCEEM Journal de Toxicologie Clinique et Experimentale. (SPPIF, B.P.22,
F-41353 Vineuil, France) V.5- 1985- Volume(issue)/page/year: 7,223,1987
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : >640 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 23,201,1992
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : >30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 23,201,1992
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Behavioral - rigidity (including catalepsy)
REFERENCE :
JTCEEM Journal de Toxicologie Clinique et Experimentale. (SPPIF, B.P.22,
F-41353 Vineuil, France) V.5- 1985- Volume(issue)/page/year: 7,223,1987
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 21 mg/kg
SEX/DURATION : female 14-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
PNPPD7 Progress in Neuro-Psychopharmacology and Biological Psychiatry.
(Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6-
1982- Volume(issue)/page/year: 17,151,1993
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE : 220 mg/kg
SEX/DURATION : female 11-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview
Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 22,43,1991
*** END OF RECORD ***
|
|
|
ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Illicium anisatum L., leaf extractSUBSTANCE DEFINITION :Plant belonging to the family MagnoliaceaeREFERENCE :NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (NipponYakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year:55,524,1959
| 93196-20-4 |
Hydrazine, (2-(m-methoxyphenoxy)ethyl)-, maleate
| 70145-85-6 |
Illicium anisatum L., root extractSUBSTANCE DEFINITION :Plant belonging to the family MagnoliaceaeREFERENCE :NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (NipponYakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year:55,524,1959
| 70145-85-6 |
Illicium anisatum L., stem extractSUBSTANCE DEFINITION :Plant belonging to the family MagnoliaceaeREFERENCE :NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (NipponYakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year:55,524,1959
| 70145-85-6 |
Illicium griffithii Hook.f. & Thoms., extractexcluding rootsSUBSTANCE DEFINITION :Plant belonging to the family MagnoliaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 26,883,1988
| 70145-85-6 |
Imanin
| 11113-64-7 |
Imbrimycin
| 57515-29-4 |
Imferon
| 9004-66-4 |
Imgreite
| 24270-51-7 |
3H-Imidazo(2,1-b)(3)benzazepine,2,5,6,11-tetrahydro-, sulfate (1:1)
| 121771-84-4 |
8,11-Iminoazepino(1,2-b)isoquinoline-10-carboxylicacid, 5,7,8,9,10,11,11a,12-octahydro-1-chloro-7-cyano-5-(hydroxymethyl)-4-methoxy-13-methyl-
| 118560-27-3 |
9H-Imidazo(1,2-a)benzimidazole,2-(p-bromophenyl)-9-(2-(diethylamino)ethyl)-,dihydrochloride
| 38652-51-6 |
Hydrazine, (1-(o-methoxyphenoxymethyl)ethyl)-,hydrochloride
| 70145-88-9 |
9H-Imidazo(1,2-a)benzimidazole,2-tert-butyl-9-(2-(diethylamino)ethyl)-,dihydrochloride
| 72025-08-2 |
9H-Imidazo(1,2-a)benzimidazole-3-carboxylic acid,9-butyl-2-((methyltricyclo(3.3.1.1(sup3,7))dec-1-ylamino)methyl)-, methyl ester,dihydrochloride
| 119294-99-4 |
9H-Imidazo(1,2-a)benzimidazole-3-carboxylic acid,9-(2-(diethylamino)ethyl)-2-methyl-, methyl ester,dihydrochloride
| 41472-74-6 |
9H-Imidazo(1,2-a)benzimidazole-3-carboxylic acid,9-methyl-2-((methyltricyclo (3.3.1.1(sup3,7))dec-1-ylamino)methyl)-, ethyl ester,dihydrobromide
| 119294-98-3 |
9H-Imidazo(1,2-a)benzimidazole-3-carboxylic acid,9-methyl-2-((methyltricyclo (3.3.1.1(sup3,7))dec-1-ylamino)methyl)-, methyl ester,dihydrochloride
| 119294-97-2 |
9H-Imidazo(1,2-a)benzimidazole,9-(2-(diethylamino)ethyl)-2-(p-methoxyphenyl)-,dihydrochloride
| 72025-06-0 |
9H-Imidazo(1,2-a)benzimidazole,9-(2-(diethylamino)ethyl)-3-(methylcarbonyl)-2-phenyl-, dihydrochloride
| 41472-76-8 |
9H-Imidazo(1,2-a)benzimidazole,9-(2-(diethylamino)ethyl)-2-methyl-, dihydrochloride
| 23572-37-4 |
9H-Imidazo(1,2-a)benzimidazole,9-(2-(diethylamino)ethyl)-2-(1-naphthyl)-,dihydrochloride
| 72025-04-8 |
9H-Imidazo(1,2-a)benzimidazole,9-((2-diethylamino)ethyl)-2-phenyl-, dihydrochloride
| 23572-32-9 |
Hydrazine, (1-(p-methoxyphenoxymethyl)ethyl)-,maleate
| 70145-87-8 |
9H-Imidazo(1,2-A)benzimidazole,9-(2-(diethylamino)ethyl)-2-phenyl-, dinitrate
| 72025-10-6 |
9H-Imidazo(1,2-a)benzimidazole,9-(2-(diethylamino)ethyl)-2-phenyl-, sulfate
| 72025-11-7 |
3H-Imidazo(1,2-a)benzimidazole, 2,9-dihydro-9-butyl-,monohydrochloride
| 111679-07-3 |
3H-Imidazo(1,2-a)benzimidazole,2,9-dihydro-9-ethyl-2-phenyl-, monohydrochloride
| 111679-15-3 |
3H-Imidazo(1,2-a)benzimidazole,2,9-dihydro-9-methyl-, monohydrochloride
| 109753-62-0 |
9H-Imidazo(1,2-a)benzimidazole,2,3-dihydro-1-methyl-2-phenyl-, dihydrochloride
| 109753-62-0 |
3H-Imidazo(1,2-a)benzimidazole,2,9-dihydro-9-(2-(1-piperidinyl)ethyl)-,dihydrochloride
| 111679-14-2 |
3H-Imidazo(1,2-a)benzimidazole,2,9-dihydro-9-propyl-, monohydrochloride
| 111679-06-2 |
9H-Imidazo(1,2-a)benzimidazole,9-((3-dimethylamino)propyl)-2-(p-bromophenyl)-,dihydrochloride
| 38652-53-8 |
9H-Imidazo(1,2-a)benzimidazole,9-((3-dimethylamino)propyl)-2-(p-chlorophenyl)-,dihydrochloride
| 38652-52-7 |
Hydrazine, (3-(p-methoxyphenyl)-1-methylpropyl)-,oxalate (1:1)
| 38652-52-7 |
9H-Imidazo(1,2-a)benzimidazole, 1-methyl-2-phenyl-,dihydrochloride
| 38652-52-7 |
9H-Imidazo(1,2-a)benzimidazole,2-phenyl-9-(2-piperidinoethyl)-, dihydrochloride
| 23572-35-2 |
5H-Imidazo(2,1-c)(1,4)benzodiazepine
| 78105-30-3 |
5H-Imidazo(2,1-c)(1,4)benzodiazepine,8-benzyloxy-7-methoxy-
| 98234-93-6 |
4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylicacid, 8-fluoro-5,6-dihydro-5-methyl-6- oxo-, ethylester
| 78755-81-4 |
5H-Imidazo(2,1-c)(1,4)benzodiazepine, 7-chloro-
| 98234-95-8 |
4H-Imidazo(1,5-a)(1,4)benzodiazepine,8-chloro-6-(2-fluorophenyl)-1-methyl-
| 59467-70-8 |
4H-Imidazo(1,5-a)(1,4)benzodiazepine,8-chloro-6-(2-fluorophenyl)-1-methyl-,(Z)-2-butenedioate (1:1)
| 59467-94-6 |
4H-Imidazo(1,5-a)(1,4)benzodiazepine,8-chloro-6-(2-fluorophenyl)-1-methyl-, hydrochloride
| 59467-96-8 |
5H-Imidazo(2,1-c)(1,4)benzodiazepine, 10,11-dihydro-
| 78105-31-4 |
Hydrazine, (2-(p-methoxyphenylthio)ethyl)-, maleate
| 70145-82-3 |
Imidazo(4,5,1-jk)(1,4)benzodiazepine,4,5-dihydro-9-chloro-7-ethoxy-2-methyl-
| 66596-66-5 |
Imidazo(4,5,1-jk)(1,4)benzodiazepine,4,5-dihydro-9-chloro-7-ethoxy-2-(phenylmethyl)-
| 66596-71-2 |
5H-Imidazo(2,1-c)(1,4-benzodiazepine,9,10-dihydro-7,8-dimethoxy-
| 98234-96-9 |
5H-Imidazo(2,1-c)(1,4)benzodiazepine, 7,8-dimethoxy-
| 98234-92-5 |
|
|