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MSDS  : Indole, 1-((2-(dimethylamino)ethyl)methylamino)-3-phenyl-, hydrochloride
CAS  : 57647-35-5
SYNONYMS  : * Binedaline hydrochloride * Binodaline hydrochloride * Binodalin-hydrochlorid * 1-(Dimethylaminoethyl-methyl)amino-3-phenylindole hydrochloride * 1-(omega-Dimethylaminoethylmethyl)amino-3-phenylindole hydrochloride * Ethylenediamine, N'-(3-phenyl-1-indolyl)-N,N,N'-trimethyl-, hydrochloride * Ixprim * RU-39780 * Scha-1059 * Sgd-scha 1059 * N,N,N'-Trimethyl-N'-(3-phenyl-1H-indol-1-yl)-1,2-ethanediamine monohydrochloride
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : NL7440000
CHEMICAL NAME : Indole,
1-((2-(dimethylamino)ethyl)methylamino)-3-phenyl-,
hydrochloride
CAS REGISTRY NUMBER : 57647-35-5
LAST UPDATED : 199406
DATA ITEMS CITED : 7
MOLECULAR FORMULA : C19-H23-N3.Cl-H
MOLECULAR WEIGHT : 329.91
WISWESSER LINE NOTATION : T56 BNJ BN1&2N1&1 DR &GH
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Binedaline hydrochloride
* Binodaline hydrochloride
* Binodalin-hydrochlorid
* 1-(Dimethylaminoethyl-methyl)amino-3-phenylindole hydrochloride
* 1-(omega-Dimethylaminoethylmethyl)amino-3-phenylindole hydrochloride
* Ethylenediamine, N'-(3-phenyl-1-indolyl)-N,N,N'-trimethyl-, hydrochloride
* Ixprim
* RU-39780
* Scha-1059
* Sgd-scha 1059
* N,N,N'-Trimethyl-N'-(3-phenyl-1H-indol-1-yl)-1,2-ethanediamine
monohydrochloride

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1160 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - antipsychotic
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 33,726,1983

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 26 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 33,726,1983

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 760 mg/kg
TOXIC EFFECTS :
Behavioral - antipsychotic
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 33,726,1983

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 54 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 33,726,1983

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : >20 mg/kg
TOXIC EFFECTS :
Cardiac - arrhythmias (including changes in conduction)
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - nausea or vomiting
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 33,726,1983

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 50800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 33,726,1983

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 6 gm/kg/3W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 33,726,1983

*** END OF RECORD ***
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