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MSDS  : Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, D-
CAS  : 13045-94-8
SYNONYMS  : * 4-(Bis(2-chloroethyl)amino)-D-phenylalanine * (+)-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine * D-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine * 3026 C.B. * CB-3026 * p-Di-(2-chloroethyl)-amino-D-phenylalanine * p-Di(2-chloroethyl)amino-d-phenylalanine * Medfalan * Medphalan * NSC-35051 * D-Phenylalanine, 4-(bis(2-chloroethyl)amino)- * D-Phenylalanine mustard * D-Sarcolysine
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : AY3370000
CHEMICAL NAME : Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, D-
CAS REGISTRY NUMBER : 13045-94-8
LAST UPDATED : 199510
DATA ITEMS CITED : 8
MOLECULAR FORMULA : C13-H18-Cl2-N2-O2
MOLECULAR WEIGHT : 305.23
WISWESSER LINE NOTATION : QVYZ1R DN2G2G -D
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* 4-(Bis(2-chloroethyl)amino)-D-phenylalanine
* (+)-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine
* D-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine
* 3026 C.B.
* CB-3026
* p-Di-(2-chloroethyl)-amino-D-phenylalanine
* p-Di(2-chloroethyl)amino-d-phenylalanine
* Medfalan
* Medphalan
* NSC-35051
* D-Phenylalanine, 4-(bis(2-chloroethyl)amino)-
* D-Phenylalanine mustard
* D-Sarcolysine

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intracerebral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 113 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
Volume(issue)/page/year: 18,760,1966

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 120 mg/kg/9W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Skin and Appendages - tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year:
10,363,1956

** MUTATION DATA **

TYPE OF TEST : Specific locus test
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 10700 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
30,195,1970

TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 10 mmol/L
REFERENCE :
JOGNAU Journal of Genetics. (Belghoria, India) V.1-63, 1910-77.
Discontinued. Volume(issue)/page/year: 54,146,1956

*** REVIEWS ***

IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 9,167,1975

IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 9,167,1975

IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Alanine,3-(p((bis(2-chloroethyl)amino)methyl)phenyl)-,dihydrochloride 2185-97-9
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenoxy)- 2185-97-9
Alanine,3-(p-(p-(bis(2-chloroethyl)amino)phenoxy)phenyl)-,DL- 857-95-4
Alanine,3-(p-(p-(bis(2-chloroethyl)amino)phenoxy)phenyl)-,sodium salt 857-95-4
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)- 857-95-4
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, D- 13045-94-8
3'-Adenylic acid, 5'-(dihydrogen phosphate),5'-anhydride with sulfuric acid 482-67-7
Alanine, 3-(m-(bis(2-chloroethyl)amino)phenyl)-, DL- 1088-79-5
Alanine, 3-(m-(bis(2-chloroethyl)amino)phenyl)-, L- 1088-80-8
Alanine, 3-(o-(bis(2-chloroethyl)amino)phenyl)-, DL- 342-95-0
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, DL- 531-76-0
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, L- 148-82-3
beta-Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)- 1952-98-3
Alanine,N-((4-(bis(2-chloroethyl)amino)phenyl)acetyl)-3-(p-chlorophenyl)-, DL- 55327-81-6
Alanine,3-(p-(bis(2-chloroethyl)amino)phenyl)-N-(L-alanyl-L-lysyl)-, methyl ester, trihydrobromide 55327-81-6
Alanine,3-(p-(bis(2-chloroethyl)amino)phenyl)-N-(L-alanyl-L-valyl)-, ethyl ester, dihydrochloride, (-)- 55327-81-6
Alanine,3-(p-(bis(2-chloroethyl)amino)phenyl)-N-(L-arginyl-L-arginyl-L-norleucyl)-, methyl ester,hexahydrochloride 102516-63-2
5'-Adenylic acid, compd. with1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxyisoquinoline (1:1) 39024-96-9
Alanine,2-(5-(bis(2-chloroethyl)amino)-1-phenyl-2-benzimidazolyl)- 73712-01-3
Alanine,3-(p-(bis(2-chloroethyl)amino)phenyl)-N-formyl-, L- 35849-41-3
Alanine,N-(3-(2-(bis(2-chloroethyl)amino)phenyl)-N-formylalanyl)-3-phenyl-, ethyl ester 35849-41-3
Alanine,3-(p-(bis(2-chloroethyl)amino)phenyl)-N-formyl-,ethyl ester, (-)- 35849-41-3
Alanine, 3-(m-(bis(2-chloroethyl)amino)phenyl)-,hydrochloride, DL- 4213-34-7
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-,hydrochloride, D- 4213-32-5
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-,hydrochloride, DL 1465-26-5
Alanine,3-(p-(bis(2-chloroethyl)amino)phenyl)-N-L-leucyl-,ethyl ester, hydrochloride, hydrate, (-)- 1465-26-5
Alanine,3-(p-(bis(2-chloroethyl)amino)phenyl)-N-L-lysyl-,methyl ester, trihydrochloride 62978-57-8
Alanine,3-(p-(bis(2-chloroethyl)amino)phenyl)-N-(L-lysyl-L-valyl)-, hydrochloride 62978-50-1
5'-Adenylic acid, disodium salt 4578-31-8
Alanine,3-(p-(bis(2-chloroethyl)amino)phenyl)-2-methyl- 64977-06-6
L-Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-,methyl ester, monohydrochloride 64977-06-6
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-,monohydrochloride, L- 3223-07-2
Alanine,3-(p-(bis(2-chloroethyl)amino)phenyl)-N-(L-3-phenylalanyl)-, ethyl ester, hydrochloride, (-)- 3223-07-2
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-,sodium salt, D- 3223-07-2
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-,sodium salt, DL- 3223-07-2
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-,sodium salt, L- 3223-07-2
Alanine,3-(p-(bis(2-chloroethyl)amino)phenyl)-N-L-valyl-,ethyl ester, hydrochloride, hydrate, (-)- 3223-07-2
Alanine,3-(p-(bis(2-chloroethyl)amino)phenyl)-N-(valyl-L-glycyl)-, ethyl ester, dihydrochloride, (-)- 3223-07-2
Alanine,3-(p-(bis(2-chloroethyl)amino)phenyl)-N-(valylglycyl-L-glycyl)-, ethyl ester, dihydrochloride, dihydrate 3223-07-2
Adenosine, 2'-deoxy-, 5'-(tetrahydrogen triphosphate) 1927-31-7
5'-Adenylic acid, and glutathione, dihydrate 1927-31-7
D,L-Alanine,N-(((2-(bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin-4-yl) hydroxyamino)carbonyl)-, ethylester, P-oxide 97139-42-9
Alanine, 2,2-bis(2-chloroethyl)hydrazide,hydrobromide 92352-08-4
Alanine, N,N-bis(2-chloroethyl)-, hydrochloride 92352-08-4
Alanine, N,N'-bis(2-chloroethyl)-, hydrochloride 2752-21-8
beta-Alanine, N,N-bis(2-chloroethyl)-, hydrochloride 98435-03-1
Alanine, N,N-bis(2-chloroethyl)-, hydrochloride, DL- 3374-04-7
Alanine, N,N-bis(2-chloroethyl)-, N-oxide,hydrochloride 98435-06-4
Alanine,3-((4,6-bis(dimethylamino)-s-triazin-2-yl)thio)- 64124-19-2
Alanine, 3-(p-(bis(2-fluoroethyl)amino)phenyl)- 4252-40-8

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