*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : AY3340000
CHEMICAL NAME : Alanine,
3-(p-(p-(bis(2-chloroethyl)amino)phenoxy)phenyl)-,
DL-
CAS REGISTRY NUMBER : 857-95-4
LAST UPDATED : 199807
DATA ITEMS CITED : 10
MOLECULAR FORMULA : C19-H22-Cl2-N2-O3
MOLECULAR WEIGHT : 397.33
WISWESSER LINE NOTATION : QVYZ1R DOR DN2G2G
COMPOUND DESCRIPTOR : Mutagen
SYNONYMS/TRADE NAMES :
* O-(4-(Bis(2-chloroethyl)amino)phenyl)-DL-tyrosine
* Fenitirin
* Phentyrin
* DL-Tyrosine, O-(4-(bis(2-chloroethyl)amino)phenyl)-
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 620 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
Liver - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 43,100,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 115 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
Liver - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 43,100,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 62 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
Liver - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 43,100,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 360 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
Liver - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 43,100,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 110 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
Liver - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 43,100,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 30 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
Liver - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 43,100,1980
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 15 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 43,100,1980
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 120 mg/kg/10D-I
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from large intestine
Blood - changes in bone marrow (not otherwise specified)
Related to Chronic Data - death
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 43,100,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 6 mg/kg/10D-I
TOXIC EFFECTS :
Cardiac - EKG changes not diagnostic of specified effects
Kidney, Ureter, Bladder - other changes
Blood - changes in spleen
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 43,100,1980
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
*** END OF RECORD ***
|
|
|
ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Alanine,3-(p((bis(2-chloroethyl)amino)methyl)phenyl)-,dihydrochloride
| 2185-97-9 |
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenoxy)-
| 2185-97-9 |
Alanine,3-(p-(p-(bis(2-chloroethyl)amino)phenoxy)phenyl)-,DL-
| 857-95-4 |
Alanine,3-(p-(p-(bis(2-chloroethyl)amino)phenoxy)phenyl)-,sodium salt
| 857-95-4 |
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-
| 857-95-4 |
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, D-
| 13045-94-8 |
3'-Adenylic acid, 5'-(dihydrogen phosphate),5'-anhydride with sulfuric acid
| 482-67-7 |
Alanine, 3-(m-(bis(2-chloroethyl)amino)phenyl)-, DL-
| 1088-79-5 |
Alanine, 3-(m-(bis(2-chloroethyl)amino)phenyl)-, L-
| 1088-80-8 |
Alanine, 3-(o-(bis(2-chloroethyl)amino)phenyl)-, DL-
| 342-95-0 |
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, DL-
| 531-76-0 |
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, L-
| 148-82-3 |
beta-Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-
| 1952-98-3 |
Alanine,N-((4-(bis(2-chloroethyl)amino)phenyl)acetyl)-3-(p-chlorophenyl)-, DL-
| 55327-81-6 |
Alanine,3-(p-(bis(2-chloroethyl)amino)phenyl)-N-(L-alanyl-L-lysyl)-, methyl ester, trihydrobromide
| 55327-81-6 |
Alanine,3-(p-(bis(2-chloroethyl)amino)phenyl)-N-(L-alanyl-L-valyl)-, ethyl ester, dihydrochloride, (-)-
| 55327-81-6 |
Alanine,3-(p-(bis(2-chloroethyl)amino)phenyl)-N-(L-arginyl-L-arginyl-L-norleucyl)-, methyl ester,hexahydrochloride
| 102516-63-2 |
5'-Adenylic acid, compd. with1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxyisoquinoline (1:1)
| 39024-96-9 |
Alanine,2-(5-(bis(2-chloroethyl)amino)-1-phenyl-2-benzimidazolyl)-
| 73712-01-3 |
Alanine,3-(p-(bis(2-chloroethyl)amino)phenyl)-N-formyl-, L-
| 35849-41-3 |
Alanine,N-(3-(2-(bis(2-chloroethyl)amino)phenyl)-N-formylalanyl)-3-phenyl-, ethyl ester
| 35849-41-3 |
Alanine,3-(p-(bis(2-chloroethyl)amino)phenyl)-N-formyl-,ethyl ester, (-)-
| 35849-41-3 |
Alanine, 3-(m-(bis(2-chloroethyl)amino)phenyl)-,hydrochloride, DL-
| 4213-34-7 |
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-,hydrochloride, D-
| 4213-32-5 |
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-,hydrochloride, DL
| 1465-26-5 |
Alanine,3-(p-(bis(2-chloroethyl)amino)phenyl)-N-L-leucyl-,ethyl ester, hydrochloride, hydrate, (-)-
| 1465-26-5 |
Alanine,3-(p-(bis(2-chloroethyl)amino)phenyl)-N-L-lysyl-,methyl ester, trihydrochloride
| 62978-57-8 |
Alanine,3-(p-(bis(2-chloroethyl)amino)phenyl)-N-(L-lysyl-L-valyl)-, hydrochloride
| 62978-50-1 |
5'-Adenylic acid, disodium salt
| 4578-31-8 |
Alanine,3-(p-(bis(2-chloroethyl)amino)phenyl)-2-methyl-
| 64977-06-6 |
L-Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-,methyl ester, monohydrochloride
| 64977-06-6 |
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-,monohydrochloride, L-
| 3223-07-2 |
Alanine,3-(p-(bis(2-chloroethyl)amino)phenyl)-N-(L-3-phenylalanyl)-, ethyl ester, hydrochloride, (-)-
| 3223-07-2 |
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-,sodium salt, D-
| 3223-07-2 |
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-,sodium salt, DL-
| 3223-07-2 |
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-,sodium salt, L-
| 3223-07-2 |
Alanine,3-(p-(bis(2-chloroethyl)amino)phenyl)-N-L-valyl-,ethyl ester, hydrochloride, hydrate, (-)-
| 3223-07-2 |
Alanine,3-(p-(bis(2-chloroethyl)amino)phenyl)-N-(valyl-L-glycyl)-, ethyl ester, dihydrochloride, (-)-
| 3223-07-2 |
Alanine,3-(p-(bis(2-chloroethyl)amino)phenyl)-N-(valylglycyl-L-glycyl)-, ethyl ester, dihydrochloride, dihydrate
| 3223-07-2 |
Adenosine, 2'-deoxy-, 5'-(tetrahydrogen triphosphate)
| 1927-31-7 |
5'-Adenylic acid, and glutathione, dihydrate
| 1927-31-7 |
D,L-Alanine,N-(((2-(bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin-4-yl) hydroxyamino)carbonyl)-, ethylester, P-oxide
| 97139-42-9 |
Alanine, 2,2-bis(2-chloroethyl)hydrazide,hydrobromide
| 92352-08-4 |
Alanine, N,N-bis(2-chloroethyl)-, hydrochloride
| 92352-08-4 |
Alanine, N,N'-bis(2-chloroethyl)-, hydrochloride
| 2752-21-8 |
beta-Alanine, N,N-bis(2-chloroethyl)-, hydrochloride
| 98435-03-1 |
Alanine, N,N-bis(2-chloroethyl)-, hydrochloride, DL-
| 3374-04-7 |
Alanine, N,N-bis(2-chloroethyl)-, N-oxide,hydrochloride
| 98435-06-4 |
Alanine,3-((4,6-bis(dimethylamino)-s-triazin-2-yl)thio)-
| 64124-19-2 |
Alanine, 3-(p-(bis(2-fluoroethyl)amino)phenyl)-
| 4252-40-8 |
|
|