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MSDS  : Indol-5-ol, 3-(2-aminoethyl)-
CAS  : 50-67-9
SYNONYMS  : * 3-(beta-Aminoethyl)-5-hydroxyindole * 3-(2-Aminoethyl)indol-5-ol * Antemoqua * Antemovis * Ds substance * Enteramine * Hippophain * 5-HT * 5-Hta * 5-Hydroxy-3-(beta-aminoethyl)indole * 5-Hydroxytryptamine * Serotonin * Serotonine * Substance DS * Substanz DS * Thrombocytin * Thrombotonin * Tryptamine, 5-hydroxy-
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : NM2450000
CHEMICAL NAME : Indol-5-ol, 3-(2-aminoethyl)-
CAS REGISTRY NUMBER : 50-67-9
BEILSTEIN REFERENCE NO. : 0143524
REFERENCE : 5-22-12-00016 (Beilstein Handbook Reference)
LAST UPDATED : 199709
DATA ITEMS CITED : 27
MOLECULAR FORMULA : C10-H12-N2-O
MOLECULAR WEIGHT : 176.24
WISWESSER LINE NOTATION : T56 BMJ D2Z GQ
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* 3-(beta-Aminoethyl)-5-hydroxyindole
* 3-(2-Aminoethyl)indol-5-ol
* Antemoqua
* Antemovis
* Ds substance
* Enteramine
* Hippophain
* 5-HT
* 5-Hta
* 5-Hydroxy-3-(beta-aminoethyl)indole
* 5-Hydroxytryptamine
* Serotonin
* Serotonine
* Substance DS
* Substanz DS
* Thrombocytin
* Thrombotonin
* Tryptamine, 5-hydroxy-

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 285 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3,
1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year:
2,17,1963

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3,
1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year:
2,17,1963

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MZUZA8 Meditsinskii Zhurnal Uzbekistana. (V/O Mezhdunarodnaya Kniga, 113095
Moscow, USSR) No.1- 1957- Volume(issue)/page/year: (3),61,1985

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IJPPAZ Indian Journal of Physiology and Pharmacology. (All India Institute
of Medical Sciences, Dept. of Physiology, Ansari Nagar, New Delhi 110 029,
India) V.1- 1957- Volume(issue)/page/year: 17,31,1973

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 601 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 26,10,1963

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 81 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 26,10,1963

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 112,319,1957

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca
Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(1),122,1982

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 5 mg/kg
TOXIC EFFECTS :
Cardiac - other changes
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 26,10,1963

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 12800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 168,373,1967

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 10 mg/kg
SEX/DURATION : female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
FKGCAR Fortschritte der Kiefer-und Gesichts-Chirurgie. (Georg Thieme
Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1955-
Volume(issue)/page/year: 21,226,1976

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 10 mg/kg
SEX/DURATION : female 18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50;
V.70-99, 1960-75. For publisher information, see APLMAS.
Volume(issue)/page/year: 81,257,1966

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 20 mg/kg
SEX/DURATION : female 6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
REFERENCE :
ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY
10003) V.1- 1906/08- Volume(issue)/page/year: 196,71A,1980

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 110 mg/kg
SEX/DURATION : female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - body wall
REFERENCE :
JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial
Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year:
63,394,1963

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 110 mg/kg
SEX/DURATION : female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial
Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year:
63,394,1963

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 10 mg/kg
SEX/DURATION : female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 25,626,1975

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 100 mg/kg
SEX/DURATION : male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
accessory glands
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston
St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year:
71,827,1962

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 240 mg/kg
SEX/DURATION : female 1-6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32,
Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-
Volume(issue)/page/year: 26,85,1963

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 320 mg/kg
SEX/DURATION : female 14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32,
Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-
Volume(issue)/page/year: 26,85,1963

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE : 10 mg/kg
SEX/DURATION : female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 58,406,1969

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE : 10 mg/kg
SEX/DURATION : female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 58,406,1969

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE : 1 mg/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - body wall
Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 58,406,1969

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE : 240 mg/kg
SEX/DURATION : female 11-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
131,1101,1960

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE : 10 mg/kg
SEX/DURATION : female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 58,406,1969

*** REVIEWS ***

TOXICOLOGY REVIEW
ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For
publisher information, see ARPTDI. Volume(issue)/page/year: 5,447,1965

TOXICOLOGY REVIEW
PRSMA4 Proceedings of the Royal Society of Medicine. (New York, NY) V.1-70,
1907-77. For publisher information, see JRSMD9. Volume(issue)/page/year:
62,317,1969

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6095
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 202 (estimated)
No. of Female Employees: 195 (estimated)


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Indolo(1,7-ab)(1)benzazepine-1-ethanamine,6,7-dihydro-N-methyl-N-(phenylmethyl)-,monohydrochloride 57529-83-6
Indolo(1,7-ab)(1)benzazepine-1-ethanamine,6,7-dihydro-N,N,2-trimethyl- 57529-86-9
Indolo(1,7-ab)(1)benzazepine-1-methanamine,6,7-dihydro-N,N-dimethyl- 57529-89-2
Indolo(1,7-ab)(1)benzazepine-2-methanamine,6,7-dihydro-N,N-dimethyl-, monohydrochloride 41987-47-7
Indolo(1,7-ab)(1)benzazepine-2-methanamine,6,7-dihydro-N,N-dimethyl-1-phenyl- 57529-92-7
Indolo(1,7-ab)(1)benzazepine-2-methanamine,6,7-dihydro-N,N,1-trimethyl- 57529-91-6
2-Indolinone,3-(2-(tert-butylamino)ethyl)-1-(dimethylamino)-3-phenyl-, monohydrochloride 40713-82-4
7H-Indolo(3,4-gh)(1,4)benzoxazine,4,6,6a,8,9,10a-hexahydro-5-bromo-7-methyl-, oxalate,(+-)-(6-ars,10-ars)- 84132-04-7
7H-Indolo(3,4-gh)(1,4)benzoxazine,4,6,6a,8,9,10a-hexahydro-7-methyl-,monohydrochloride, (+-)-, (6-ars,10-ars)- 77291-63-5
7H-Indolo(3,4-gh)(1,4)benzoxazine,4,6,6a,8,9,10a-hexahydro-, monohydrochloride, (+-)-,(6-ars,10-ars) 80952-17-6
7H-Indolo(3,4-gh)(1,4)benzoxazine,4,6,6a,8,9,10a-hexahydro-7-propyl-,monohydrochloride, (+-)-, (6-ars,10-ars)- 80952-18-7
7H-Indolo(3,4-gh)(1,4)benzoxazine,4,5,5a,6,6a,8,9,10a-octahydro-7-propyl-, (+-)-,(5a-RS(5a-alpha,6a-beta,10a-alpha))- 84132-03-6
Indolo(7,6-g)indole-3,8-dimethanaminium,1,6-dihydro-N,N,N,N',N',N'-hexamethyl-, bis(methylsulfate) 84132-03-6
Indol-5-ol 1953-54-4
1H-Indol-5-ol,2-(4-(acetyloxy)phenyl)-1-ethyl-3-methyl-, acetate(ester) 86111-26-4
Indol-5-ol, 3-(2-aminoethyl)- 50-67-9
Indol-5-ol, 3-(2-aminoethyl)-, acetate (ester),adipate (1:1) 19628-29-6
2-Indolinone,1-((p-chlorobenzyl)methylamino)-3-(2-(diethylamino)ethyl)-3-phenyl- 33391-15-0
Indol-5-ol, 3-(2-aminoethyl)-, adipate 16031-83-7
Indol-5-ol, 3-(2-aminoethyl)-, p-aminobenzoate(ester), dihydrochloride 19616-00-3
Indol-5-ol, 3-(2-aminoethyl)-, benzoate (ester),monoacetate 18518-64-4
Indol-5-ol, 3-(2-aminoethyl)-,(m-chlorophenyl)carbamate, hydrochloride 73816-59-8
Indol-5-ol, 3-(2-aminoethyl)-, compd. with creatininesulfate 971-74-4
Indol-5-ol, 3-(2-aminoethyl)-, compd. with creatininesulfate monohydrate, mixed with sodium nitrite 971-74-4
Indol-5-ol, 3-(2-aminoethyl)-, diethylcarbamate,acetate 73816-60-1
Indol-5-ol, 3-(2-aminoethyl)-, maleate 18525-25-2
Indol-5-ol, 3-(2-aminoethyl)-, methylcarbamate,hydrochloride 73816-61-2
1H-Indol-5-ol, 3-(2-aminoethyl)-, monohydrochloride,nitrosated 73816-61-2
2-Indolinone,1-((o-chlorobenzyl)methylamino)-3-(3-(diethylamino)propyl)-3-phenyl- 33456-35-8
Indol-5-ol, 3-(2-aminoethyl)-, phenylcarbamate,hydrochloride 73816-62-3
Indol-5-ol, 3-(2-aminoethyl)-, propionate (ester),adipate (1:1) 19628-28-5
Indol-5-ol, 3-(2-aminoethyl)-, succinate 21716-89-2
Indol-5-ol, 3-(2-aminoethyl)-, sulfate 2906-14-1
1H-Indol-5-ol, 3-(2-(4-amino-1-piperidinyl)ethyl)-,hydrochloride, hydrate (2:4:1) 35633-80-8
Indol-5-ol, 3-(2-aminopropyl)-, hydrochloride 101651-82-5
Indol-6-ol, 3-(2-aminopropyl)-5-methoxy-,hydrochloride 101651-83-6
Indol-3-ol,2-(((p-(bis(2-chloroethyl)amino)phenyl)imino)methyl)- 101651-84-7
3-Indolol,5-bromo-2-(9-chloro-3-hydroxynaphtho(1,2-b)thien-2-yl)-, bis(hydrogen sulfate), disodium salt 101651-84-7
Indol-6-ol,4-chloro-2-(2,6-dichloro-4-hydroxyphenyl)-1-ethyl- 83364-03-8
2-Indolinone,1-((p-chlorobenzyl)methylamino)-3-(2-(dimethylamino)ethyl)-3-phenyl- 33391-14-9
Indol-6-ol,4-chloro-2-(2,6-dichloro-4-hydroxyphenyl)-1-methyl- 83364-02-7
Indol-5-ol, 3-(2,3-diaminopropyl)-, dihydrochloride 101651-85-8
Indol-5-ol, 3-(2-(dibutylamino)ethyl)-,monohydrochloride 101651-85-8
1H-Indol-4-ol,4-(2-(3,4-dimethoxyphenyl)ethenyl)octahydro-,(3a-alpha,4-beta,4(Z),7a- alpha)-(+-)-,(Z)-2-butenedioate (2:1) (salt) 66690-81-1
Indol-4-ol, 3-(2-(dimethylamino)ethyl)- 520-53-6
Indol-5-ol, 3-(2-(dimethylamino)ethyl)- 487-93-4
Indol-6-ol, 3-(2-(dimethylamino)ethyl)- 1476-33-1
1H-Indol-5-ol, 3-(2-(dimethylamino)ethyl)-, bioxalate 4382-50-7
Indol-4-ol, 3-(2-(dimethylamino)ethyl)-, dihydrogenphosphate 520-52-5
Indol-5-ol, 3-(2-(dimethylamino)ethyl)-, oxalate 2963-79-3

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