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MSDS  : Indol-5-ol, 3-(2-aminoethyl)-, compd. with creatinine sulfate
CAS  : 971-74-4
SYNONYMS  : * 3-(2-Aminoethyl)indol-5-ol, creatinine sulfate * Creatinine, sulfate, compd. with 3-(2-aminoethyl)indole-5-ol (1:1:1), monohydrate * Creatinine, sulfate, compd. with 3-(2-aminoethyl)indol-5-ol (1:1:1) * 5-HT creatinine sulfate * 5-Hydroxytryptamine creatinine sulfate * 5-Hydroxytryptamine creatinine sulfate monohydrate * Serotonin creatinine sulfate monohydrate * Serotin creatinine sulfate
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : NM2550000
CHEMICAL NAME : Indol-5-ol, 3-(2-aminoethyl)-, compd. with creatinine
sulfate
CAS REGISTRY NUMBER : 971-74-4
LAST UPDATED : 199606
DATA ITEMS CITED : 23
MOLECULAR FORMULA : C10-H12-N2-O.C4-H7-N3-O.H2-O4-S.H2-O
MOLECULAR WEIGHT : 405.48
WISWESSER LINE NOTATION : T5NYMV EHJ A BUM &WSQQ &QH &622
COMPOUND DESCRIPTOR : Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* 3-(2-Aminoethyl)indol-5-ol, creatinine sulfate
* Creatinine, sulfate, compd. with 3-(2-aminoethyl)indole-5-ol (1:1:1),
monohydrate
* Creatinine, sulfate, compd. with 3-(2-aminoethyl)indol-5-ol (1:1:1)
* 5-HT creatinine sulfate
* 5-Hydroxytryptamine creatinine sulfate
* 5-Hydroxytryptamine creatinine sulfate monohydrate
* Serotonin creatinine sulfate monohydrate
* Serotin creatinine sulfate

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 257 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 105,80,1952

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 66 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 105,80,1952

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 405 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15
Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-
Volume(issue)/page/year: 94,1620,1974

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >1997 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 105,80,1952

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 352 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 105,80,1952

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 28 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - bronchiolar constriction
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 57,1543,1968

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 20 mg/kg
SEX/DURATION : female 5 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
Reproductive - Fertility - other measures of fertility
REFERENCE :
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W.
Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year:
29,151,1983

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 10 mg/kg
SEX/DURATION : female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK)
V.1-33, 1946-68. For publisher information, see BJPCBM.
Volume(issue)/page/year: 31,494,1967

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 5 mg/kg
SEX/DURATION : female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK)
V.1-33, 1946-68. For publisher information, see BJPCBM.
Volume(issue)/page/year: 31,494,1967

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 2 mg/kg
SEX/DURATION : female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK)
V.1-33, 1946-68. For publisher information, see BJPCBM.
Volume(issue)/page/year: 31,494,1967

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 20 mg/kg
SEX/DURATION : female 21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
REFERENCE :
JPBAA7 Journal of Pathology and Bacteriology. (London, UK) V.1-96,
1892-1968. For publisher information, see JPTLAS. Volume(issue)/page/year:
94,113,1967

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 10 mg/kg
SEX/DURATION : female 20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
REFERENCE :
AJPHAP American Journal of Physiology. (American Physiological Soc., 9650
Rockville Pike, Bethesda, MD 20814) V.1- 1898- Volume(issue)/page/year:
169,537,1952

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE : 20 mg/kg
SEX/DURATION : female 6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32,
Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-
Volume(issue)/page/year: 43,xxxiv,1969

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Implant
SPECIES OBSERVED : Rodent - rat
DOSE : 10 mg/kg
SEX/DURATION : male 4 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - other effects on male
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 170,464,1982

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravaginal
SPECIES OBSERVED : Rodent - rat
DOSE : 50 mg/kg
SEX/DURATION : female 6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
Reproductive - Fertility - other measures of fertility
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 44,53,1975

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE : 5 mg/kg
SEX/DURATION : female 16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022)
V.1- 1972- Volume(issue)/page/year: 2,295,1972

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE : 20 mg/kg
SEX/DURATION : female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
141,717,1963

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE : 20 mg/kg
SEX/DURATION : female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - body wall
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
141,717,1963

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE : 10 mg/kg
SEX/DURATION : female 15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - maternal-fetal exchange
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
Volume(issue)/page/year: 99,250,1967

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - mouse
DOSE : 40 mg/kg
SEX/DURATION : female 5 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32,
Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-
Volume(issue)/page/year: 43,xxxiv,1969

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3563
No. of Facilities: 10 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 53 (estimated)
No. of Female Employees: 26 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-whole sex chrom. loss

EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-reciprocal
translocation


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Indolo(1,7-ab)(1)benzazepine-1-ethanamine,6,7-dihydro-N-methyl-N-(phenylmethyl)-,monohydrochloride 57529-83-6
Indolo(1,7-ab)(1)benzazepine-1-ethanamine,6,7-dihydro-N,N,2-trimethyl- 57529-86-9
Indolo(1,7-ab)(1)benzazepine-1-methanamine,6,7-dihydro-N,N-dimethyl- 57529-89-2
Indolo(1,7-ab)(1)benzazepine-2-methanamine,6,7-dihydro-N,N-dimethyl-, monohydrochloride 41987-47-7
Indolo(1,7-ab)(1)benzazepine-2-methanamine,6,7-dihydro-N,N-dimethyl-1-phenyl- 57529-92-7
Indolo(1,7-ab)(1)benzazepine-2-methanamine,6,7-dihydro-N,N,1-trimethyl- 57529-91-6
2-Indolinone,3-(2-(tert-butylamino)ethyl)-1-(dimethylamino)-3-phenyl-, monohydrochloride 40713-82-4
7H-Indolo(3,4-gh)(1,4)benzoxazine,4,6,6a,8,9,10a-hexahydro-5-bromo-7-methyl-, oxalate,(+-)-(6-ars,10-ars)- 84132-04-7
7H-Indolo(3,4-gh)(1,4)benzoxazine,4,6,6a,8,9,10a-hexahydro-7-methyl-,monohydrochloride, (+-)-, (6-ars,10-ars)- 77291-63-5
7H-Indolo(3,4-gh)(1,4)benzoxazine,4,6,6a,8,9,10a-hexahydro-, monohydrochloride, (+-)-,(6-ars,10-ars) 80952-17-6
7H-Indolo(3,4-gh)(1,4)benzoxazine,4,6,6a,8,9,10a-hexahydro-7-propyl-,monohydrochloride, (+-)-, (6-ars,10-ars)- 80952-18-7
7H-Indolo(3,4-gh)(1,4)benzoxazine,4,5,5a,6,6a,8,9,10a-octahydro-7-propyl-, (+-)-,(5a-RS(5a-alpha,6a-beta,10a-alpha))- 84132-03-6
Indolo(7,6-g)indole-3,8-dimethanaminium,1,6-dihydro-N,N,N,N',N',N'-hexamethyl-, bis(methylsulfate) 84132-03-6
Indol-5-ol 1953-54-4
1H-Indol-5-ol,2-(4-(acetyloxy)phenyl)-1-ethyl-3-methyl-, acetate(ester) 86111-26-4
Indol-5-ol, 3-(2-aminoethyl)- 50-67-9
Indol-5-ol, 3-(2-aminoethyl)-, acetate (ester),adipate (1:1) 19628-29-6
2-Indolinone,1-((p-chlorobenzyl)methylamino)-3-(2-(diethylamino)ethyl)-3-phenyl- 33391-15-0
Indol-5-ol, 3-(2-aminoethyl)-, adipate 16031-83-7
Indol-5-ol, 3-(2-aminoethyl)-, p-aminobenzoate(ester), dihydrochloride 19616-00-3
Indol-5-ol, 3-(2-aminoethyl)-, benzoate (ester),monoacetate 18518-64-4
Indol-5-ol, 3-(2-aminoethyl)-,(m-chlorophenyl)carbamate, hydrochloride 73816-59-8
Indol-5-ol, 3-(2-aminoethyl)-, compd. with creatininesulfate 971-74-4
Indol-5-ol, 3-(2-aminoethyl)-, compd. with creatininesulfate monohydrate, mixed with sodium nitrite 971-74-4
Indol-5-ol, 3-(2-aminoethyl)-, diethylcarbamate,acetate 73816-60-1
Indol-5-ol, 3-(2-aminoethyl)-, maleate 18525-25-2
Indol-5-ol, 3-(2-aminoethyl)-, methylcarbamate,hydrochloride 73816-61-2
1H-Indol-5-ol, 3-(2-aminoethyl)-, monohydrochloride,nitrosated 73816-61-2
2-Indolinone,1-((o-chlorobenzyl)methylamino)-3-(3-(diethylamino)propyl)-3-phenyl- 33456-35-8
Indol-5-ol, 3-(2-aminoethyl)-, phenylcarbamate,hydrochloride 73816-62-3
Indol-5-ol, 3-(2-aminoethyl)-, propionate (ester),adipate (1:1) 19628-28-5
Indol-5-ol, 3-(2-aminoethyl)-, succinate 21716-89-2
Indol-5-ol, 3-(2-aminoethyl)-, sulfate 2906-14-1
1H-Indol-5-ol, 3-(2-(4-amino-1-piperidinyl)ethyl)-,hydrochloride, hydrate (2:4:1) 35633-80-8
Indol-5-ol, 3-(2-aminopropyl)-, hydrochloride 101651-82-5
Indol-6-ol, 3-(2-aminopropyl)-5-methoxy-,hydrochloride 101651-83-6
Indol-3-ol,2-(((p-(bis(2-chloroethyl)amino)phenyl)imino)methyl)- 101651-84-7
3-Indolol,5-bromo-2-(9-chloro-3-hydroxynaphtho(1,2-b)thien-2-yl)-, bis(hydrogen sulfate), disodium salt 101651-84-7
Indol-6-ol,4-chloro-2-(2,6-dichloro-4-hydroxyphenyl)-1-ethyl- 83364-03-8
2-Indolinone,1-((p-chlorobenzyl)methylamino)-3-(2-(dimethylamino)ethyl)-3-phenyl- 33391-14-9
Indol-6-ol,4-chloro-2-(2,6-dichloro-4-hydroxyphenyl)-1-methyl- 83364-02-7
Indol-5-ol, 3-(2,3-diaminopropyl)-, dihydrochloride 101651-85-8
Indol-5-ol, 3-(2-(dibutylamino)ethyl)-,monohydrochloride 101651-85-8
1H-Indol-4-ol,4-(2-(3,4-dimethoxyphenyl)ethenyl)octahydro-,(3a-alpha,4-beta,4(Z),7a- alpha)-(+-)-,(Z)-2-butenedioate (2:1) (salt) 66690-81-1
Indol-4-ol, 3-(2-(dimethylamino)ethyl)- 520-53-6
Indol-5-ol, 3-(2-(dimethylamino)ethyl)- 487-93-4
Indol-6-ol, 3-(2-(dimethylamino)ethyl)- 1476-33-1
1H-Indol-5-ol, 3-(2-(dimethylamino)ethyl)-, bioxalate 4382-50-7
Indol-4-ol, 3-(2-(dimethylamino)ethyl)-, dihydrogenphosphate 520-52-5
Indol-5-ol, 3-(2-(dimethylamino)ethyl)-, oxalate 2963-79-3

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