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MSDS  : Isonicotinamide, 2-ethylthio-
CAS  : 536-33-4
SYNONYMS  : * Aetina * Aetiva * Amidazin * Amidazine * Bayer 5312 * Ethina * Ethinamide * Ethimide * Ethionamide * Ethioniamide * alpha-Ethylisonicotinic acid thioamide * 2-Ethylisonicotinic acid thioamide * 2-Ethylisonicotinic thioamide * alpha-Ethylisonicotinoylthioamide * Ethylisothiamide * alpha-Ethylisothionicotinamide * 2-Ethylisothionicotinamide * 2-Ethyl-4-pyridinecarbothioamide * 2-Ethyl-4-thioamidylpyridine * 2-Ethyl-4-thiocarbamoylpyridine * alpha-Ethylthioisonicotinamide * 2-Ethylthioisonicotinamide * Ethyonomide * Etimid * Etiocidan * Etionamid * Etionid * Etionizina * Etionizine * Fatoliamid * F.I. 58-30 * Iridocin * Iridozin * Isothin * Isotiamida * Itiocide * Nizotin * NCI-C01694 * Rigenicid * Sertinon * Teberus * 1314 TH * TH 1314 * Thianid * Thianide * Thioamide * Tio-Mid * Trecator * Trescatyl * Trescazide * Tubermin * Tuberoid * Tuberoson
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : NS0350000
CHEMICAL NAME : Isonicotinamide, 2-ethylthio-
CAS REGISTRY NUMBER : 536-33-4
BEILSTEIN REFERENCE NO. : 0116474
REFERENCE : 5-22-02-00360 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 30
MOLECULAR FORMULA : C8-H10-N2-S
MOLECULAR WEIGHT : 166.26
WISWESSER LINE NOTATION : T6NJ B2 DYZUS
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Aetina
* Aetiva
* Amidazin
* Amidazine
* Bayer 5312
* Ethina
* Ethinamide
* Ethimide
* Ethionamide
* Ethioniamide
* alpha-Ethylisonicotinic acid thioamide
* 2-Ethylisonicotinic acid thioamide
* 2-Ethylisonicotinic thioamide
* alpha-Ethylisonicotinoylthioamide
* Ethylisothiamide
* alpha-Ethylisothionicotinamide
* 2-Ethylisothionicotinamide
* 2-Ethyl-4-pyridinecarbothioamide
* 2-Ethyl-4-thioamidylpyridine
* 2-Ethyl-4-thiocarbamoylpyridine
* alpha-Ethylthioisonicotinamide
* 2-Ethylthioisonicotinamide
* Ethyonomide
* Etimid
* Etiocidan
* Etionamid
* Etionid
* Etionizina
* Etionizine
* Fatoliamid
* F.I. 58-30
* Iridocin
* Iridozin
* Isothin
* Isotiamida
* Itiocide
* Nizotin
* NCI-C01694
* Rigenicid
* Sertinon
* Teberus
* 1314 TH
* TH 1314
* Thianid
* Thianide
* Thioamide
* Tio-Mid
* Trecator
* Trescatyl
* Trescazide
* Tubermin
* Tuberoid
* Tuberoson

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 856 mg/kg
TOXIC EFFECTS :
Liver - jaundice, other or unclassified
Liver - change in gall bladder structure or function
REFERENCE :
ARDSBL American Review of Respiratory Disease. (American Lung Assoc., 1740
Broadway, New York, NY 10019) V.80- 1959- Volume(issue)/page/year:
84,890,1961

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 482 mg/kg/5W
TOXIC EFFECTS :
Liver - jaundice, other or unclassified
Liver - change in gall bladder structure or function
REFERENCE :
ARDSBL American Review of Respiratory Disease. (American Lung Assoc., 1740
Broadway, New York, NY 10019) V.80- 1959- Volume(issue)/page/year:
87,896,1963

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,111,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 490 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,111,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,111,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 21,452,1962

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland)
V.18-24, 1966-72. For publisher information, see PJPPAA.
Volume(issue)/page/year: 23,383,1971

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1580 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,111,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 550 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UBZHD4 Ukrainskii Biokhimicheskii Zhurnal. Ukranian Biochemical Journal.
(V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.50- 1978-
Volume(issue)/page/year: 52,593,1980

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 24 gm/kg/50W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Endocrine - thyroid tumors
REFERENCE :
LAPPA5 Lavori dell'Istituto di Anatomia e Istologia Patologica, Universita
Degli Studi Perugia. (Perugia, Italy) V.1-38, 1939-78. Discontinued.
Volume(issue)/page/year: 24,145,1964

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - woman
DOSE : 600 mg/kg
SEX/DURATION : female 36-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
REFERENCE :
POMJAC Polish Medical Journal. (Warsaw, Poland) V.1-11, 1962-72.
Discontinued. Volume(issue)/page/year: 5,1152,1966

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - woman
DOSE : 5400 mg/kg
SEX/DURATION : female 12 week(s) pre-mating
female 1-38 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
POMJAC Polish Medical Journal. (Warsaw, Poland) V.1-11, 1962-72.
Discontinued. Volume(issue)/page/year: 5,1152,1966

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 1800 mg/kg
SEX/DURATION : female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - body wall
REFERENCE :
OSDIAF Osaka Shiritsu Daigaku Igaku Zasshi. Journal of the Osaka City
Medical Center. (Osaka, Japan) V.4-23, 1955-74. For publisher
information, see OIGZDE. Volume(issue)/page/year: 16,313,1967

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 900 mg/kg
SEX/DURATION : female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
OSDIAF Osaka Shiritsu Daigaku Igaku Zasshi. Journal of the Osaka City
Medical Center. (Osaka, Japan) V.4-23, 1955-74. For publisher
information, see OIGZDE. Volume(issue)/page/year: 16,313,1967

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 1800 mg/kg
SEX/DURATION : female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o
Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
information, see CGANE7. Volume(issue)/page/year: 5,236,1965

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 486 mg/kg
SEX/DURATION : female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland)
V.18-24, 1966-72. For publisher information, see PJPPAA.
Volume(issue)/page/year: 23,383,1971

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 2430 mg/kg
SEX/DURATION : female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
REFERENCE :
DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland)
V.18-24, 1966-72. For publisher information, see PJPPAA.
Volume(issue)/page/year: 23,383,1971

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 450 mg/kg
SEX/DURATION : female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
PSDTAP Proceedings of the European Society for the Study of Drug Toxicity.
(Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see
PESTD5. Volume(issue)/page/year: 10,235,1969

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE : 108 mg/kg
SEX/DURATION : female 7-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland)
V.18-24, 1966-72. For publisher information, see PJPPAA.
Volume(issue)/page/year: 23,383,1971

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE : 216 mg/kg
SEX/DURATION : female 7-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
REFERENCE :
DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland)
V.18-24, 1966-72. For publisher information, see PJPPAA.
Volume(issue)/page/year: 23,383,1971

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE : 900 mg/kg
SEX/DURATION : female 8-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
PSDTAP Proceedings of the European Society for the Study of Drug Toxicity.
(Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see
PESTD5. Volume(issue)/page/year: 10,235,1969

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE : 450 mg/kg
SEX/DURATION : female 8-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
REFERENCE :
PSDTAP Proceedings of the European Society for the Study of Drug Toxicity.
(Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see
PESTD5. Volume(issue)/page/year: 10,235,1969

** MUTATION DATA **

TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 500 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 368,59,1996

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Fibroblast
DOSE/DURATION : 400 mg/L
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year:
(96),55,1978

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 540 mg/L
REFERENCE :
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring
St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year:
27,95,1981

*** REVIEWS ***

IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 13,83,1977

IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 13,83,1977

IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5544
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 307 (estimated)
No. of Female Employees: 251 (estimated)

*** STATUS IN U.S. ***

NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-46,78


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Isonicotinamide, N-(2-aminoethyl)- 74484-66-5
Isonicotinamide, N-(5-(p-aminophenoxy)pentyl)- 101578-27-2
Isonicotinamide, N-(3,3-bis(p-chlorophenyl)propyl)- 102311-16-0
Isonicotinamide,N-(3,5-bis(4-pyridyl)-1H-1,2,4-triazolyl)-,dihydrochloride 67292-79-9
Isonicotinamide, N-cyclopropyl- 25764-75-4
Isonicotinamide, 2,6-dichloro-N-cyclopropyl-N-ethyl- 20373-56-2
Isonicotinamide, N,N-diethyl- 530-40-5
Isonicotinamide, N-(2-(diethylamino)ethyl)- 6011-13-8
Isonicotinamide, N-(3-difluoromethoxyphenyl)-,hydrochloride 54231-56-0
Isonicotinamide,N-(5,5-dimethyl-2-oxotetrahydro-3-furyl)- 77694-36-1
1H-Isoindole-1,3(2H)-dione,2-(2-((1-piperidinyl)methyl)-1H-benzimidazol-2-ylmethyl)- 115398-74-8
Isonicotinamide, N-(2,3-dimethylphenyl)-,hydrochloride 54231-55-9
Isonicotinamide, N-(3,4-dimethylphenyl)-,hydrochloride 54231-54-8
Isonicotinamide, N-(2,5-dimethylpyrrol-1-yl)- 5588-11-4
Isonicotinamide, N,N'-ethylenedi- 5588-11-4
Isonicotinamide, 2-ethylthio- 536-33-4
Isonicotinamide, N-(hydroxymethyl)- 13538-44-8
Isonicotinamide, N-(2-indol-2-ylethyl)- 63183-58-4
Isonicotinamide, N-(3-indolylmethyl)- 63183-54-0
Isonicotinamide, N-(3-(3-indolyl)propyl)-,hydrochloride, hydrate 72612-06-7
Isonicotinamide, N-(2-(5-methoxyindol-3-yl)ethyl)- 29745-43-5
1H-Isoindole-1,3(2H)-dione,2-(2-(4-(2-pyridyl)-1-piperazinyl)ethyl)-,hydrochloride 117992-70-8
Isonicotinamide, N-(3-(5-methoxy-3-indolyl)propyl)- 72612-10-3
Isonicotinamide, N,N'-methylenebis(thio-, hydrate 63905-50-0
Isonicotinamide, N-(2-(2-methyl-3-indolyl)ethyl)- 63183-56-2
Isonicotinamide, N-(2-methyl-5-phenylpyrrol-1-yl)- 93317-30-7
Isonicotinamide, N-(4-methyl-1-piperazinylmethyl)- 38221-52-2
Isonicotinamide, N-(morpholinomethyl)- 38221-50-0
Isonicotinamide, N-(4-oxo-2-thioxo-3-thiazolidinyl)- 38221-50-0
Isonicotinamide, 2-propylthio- 14222-60-7
Isonicotinamide, thio-, 1-oxide 63919-16-4
Isonicotinamidine, N-(p-chlorophenyl)- 23565-10-8
1H-Isoindole-1,3(2H)-dione,2-((1-(4-morpholinylmethyl)-1H-benzimidazol-2-yl)methyl)- 115398-75-9
1H-Isoindole-1,3(2H)-dione,2-((4-(1-pyrrolidinyl)-2-butynyl)oxy)-, ethanedioate(2:1) 74500-82-6
Isonicotinamidine, N-(3-chloro-p-tolyl)- 23564-67-2
Isonicotinamidine, N-(3,4-dichlorophenyl)- 23564-32-1
Isonicotinamidine, N-(2,5-dimethoxyphenyl)- 23564-31-0
Isonicotinamidine, N-(m-fluorophenyl)- 23565-11-9
Isonicotinamidine, N-(o-hydroxyphenyl)- 23564-33-2
Isonicotinamidine, N-(o-methoxyphenyl)- 23565-14-2
Isonicotinamidine, N-(p-methoxyphenyl)- 23565-15-3
Isonicotinamidine, N-1-naphthyl- 23565-16-4
Isonicotinamidine, N-2-naphthyl- 23564-66-1
Isonicotinamidine, N-phenyl- 23573-51-5
1H-Isoindole-1,3(2H)-dione,4,5,6,7-tetrahydro-2-(4-chlorophenyl)- 88402-43-1
Isonicotinamidine, N-(2-(2-pyridyl)-4-quinazolinyl)- 91748-42-4
Isonicotinamidine, N-p-tolyl- 23564-34-3
Isonicotinamidine,N-(alpha,alpha,alpha-trifluoro-m-tolyl)- 23565-12-0
Isonicotinamidoxime 1594-57-6
Isonicotinanilide, 4'-(bis(2-chloroethyl)amino)- 21908-17-8

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