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MSDS  : Lactic acid, compd. with 6,9-diamino-2-ethoxyacridine (1:1)
CAS  : 1837-57-6
SYNONYMS  : * 6,9-Acridinediamine, 2-ethoxy-, 2-hydroxypropanoate (1:1) * Acridine, 6,9-diamino-2-ethoxy-, compd. with lactic acid (1:1) * Acridine, 6,9-diamino-2-ethoxy-, monolactate * Acrinol * Acrolactine * 2-Aethoxy-6,9-diaminoacridinlactat * 2,5-Diamino-7-ethoxyacridine lactate * 6,9-Diamino-2-ethoxyacridine lactate * 6,9-Diamino-2-oxyethylacridine lactate * Ethacridine lactate * Ethodin * 2-Ethoxy-6,9-diaminoacridine lactate * 2-Ethoxy-6,9-diaminoacridine lactate hydrate * 2-Ethoxy-6,9-diaminoacridinium lactate * Flavitrol * Metifex * Rimaon * Rivanol * Rivinol * Vucine
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : OD4725000
CHEMICAL NAME : Lactic acid, compd. with 6,9-diamino-2-ethoxyacridine
(1:1)
CAS REGISTRY NUMBER : 1837-57-6
LAST UPDATED : 199806
DATA ITEMS CITED : 11
MOLECULAR FORMULA : C15-H15-N3-O.C3-H6-O3
MOLECULAR WEIGHT : 343.42
WISWESSER LINE NOTATION : T C666 BNJ EZ IZ LO2
COMPOUND DESCRIPTOR : Drug
Mutagen
SYNONYMS/TRADE NAMES :
* 6,9-Acridinediamine, 2-ethoxy-, 2-hydroxypropanoate (1:1)
* Acridine, 6,9-diamino-2-ethoxy-, compd. with lactic acid (1:1)
* Acridine, 6,9-diamino-2-ethoxy-, monolactate
* Acrinol
* Acrolactine
* 2-Aethoxy-6,9-diaminoacridinlactat
* 2,5-Diamino-7-ethoxyacridine lactate
* 6,9-Diamino-2-ethoxyacridine lactate
* 6,9-Diamino-2-oxyethylacridine lactate
* Ethacridine lactate
* Ethodin
* 2-Ethoxy-6,9-diaminoacridine lactate
* 2-Ethoxy-6,9-diaminoacridine lactate hydrate
* 2-Ethoxy-6,9-diaminoacridinium lactate
* Flavitrol
* Metifex
* Rimaon
* Rivanol
* Rivinol
* Vucine

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJEPA5 British Journal of Experimental Pathology. (Blackwell Scientific
Pub. Ltd., POB 88, Oxford, UK) V.1- 1920- Volume(issue)/page/year:
28,1,1947

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,6,1995

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 20 mg/kg
TOXIC EFFECTS :
Vascular - shock
REFERENCE :
BSPHAV Bulletin des Sciences Pharmacologiques. (Paris, France) V.1-49,
1899-1942. For publisher information, see APFRAD. Volume(issue)/page/year:
40,582,1933

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 48 gm/kg/30D-C
TOXIC EFFECTS :
Endocrine - other changes
Endocrine - changes in thymus weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 16,337,1978

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 420 mg/kg/21D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in spleen weight
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
Volume(issue)/page/year: 16,1038,1978

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 16 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 144,9,1985

TYPE OF TEST : DNA adduct
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 5 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981

TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 1 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 193,21,1988

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 250 mg/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.1- 1915-
Volume(issue)/page/year: 56,500,1966

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5763
No. of Facilities: 23 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 23 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY


*** END OF RECORD ***
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