*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : NY5775000
CHEMICAL NAME : Jacobine
CAS REGISTRY NUMBER : 6870-67-3
OTHER CAS REGISTRY NOS. : 471-14-7
BEILSTEIN REFERENCE NO. : 0054580
REFERENCE : 4-27-00-06827 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 10
MOLECULAR FORMULA : C18-H25-N-O6
MOLECULAR WEIGHT : 351.44
WISWESSER LINE NOTATION : T55-12- 1A Q EN IOVX OVO BUTJ M1 NQ N1 K-& BT3OX CHJ
C1
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
Natural Product
SYNONYMS/TRADE NAMES :
* 15,20-Epoxy-15,20-dihydro-12-hydroxysenecionan-11,16-dione
* NSC 89936
* Senecionan-11,16-dione, 15,20-epoxy-15,20-dihydro-12-hydroxy-,
(15-alpha,20S)-
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 77 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 75,69,1942
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
28,2237,1968
** MUTATION DATA **
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 20 umol/L
REFERENCE :
ZEVBA5 Zeitschrift fuer Vererbungslehre. (Berlin, Fed. Rep. Ger.) V.89-98,
1958-66. For publisher information, see MGGEAE. Volume(issue)/page/year:
91,74,1960
TYPE OF TEST : DNA damage
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 5 mg/kg
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 32,275,1986
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 1 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
45,3125,1985
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 10,275,1976
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 10,275,1976
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For
publisher information, see JNCIEQ. Volume(issue)/page/year: 60,1171,1976
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
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Kaur-16-en-15-one,7,20:14,20-diepoxy-1,6,7-trihydroxy-,(1-alpha,6-beta,7-alpha,14S,20S)-
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Kaur-16-en-15-one,7-alpha,20-epoxy-1-alpha,6-beta,7,14-tetrahydroxy-,(14R)-
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Kayea assamica King & Prain, extractSUBSTANCE DEFINITION :Plant belonging to the family ClusiaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 28,619,1990
| 28957-04-2 |
Jacobinia coccinea Hiern, extract
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Kazusamycin
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Kazusamycin B
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KChNr
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KDA 6SUBSTANCE DEFINITION :Water soluble perfluorinated organic of average molecular weight 600REFERENCE :MIVRA6 Microvascular Research. (Academic Press, Inc., 1 E. First St.,Duluth, MN 55802) V.1- 1968- Volume(issue)/page/year: 8,320,1974
| 59299-53-5 |
KDA 10SUBSTANCE DEFINITION :Water soluble perfluorinated organic of average molecular weight 1000REFERENCE :MIVRA6 Microvascular Research. (Academic Press, Inc., 1 E. First St.,Duluth, MN 55802) V.1- 1968- Volume(issue)/page/year: 8,320,1974
| 59299-53-5 |
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| 59299-53-5 |
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Kel-F
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Kevlar aramide fibers
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KEP
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Jacobine
| 6870-67-3 |
Kephalin
| 1405-71-6 |
Keracyanin
| 18719-76-1 |
Keratin
| 68238-35-7 |
Kerosene
| 8008-20-6 |
Kerosene (petroleum), hydrotreated
| 64742-47-8 |
Kerosene soot extractSUBSTANCE DEFINITION :Obtained through the burning of kerosene fuel in a continuous flow combustorand collected with a water cooled probeREFERENCE :JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)V.61-79, 1978-87. For publisher information, see JNCIEQ.Volume(issue)/page/year: 63,309,1979
| 64742-47-8 |
Kerosine, hydrodesulfurized
| 64742-81-0 |
Kessco X-159
| 101809-57-8 |
Kessco X-169
| 101809-58-9 |
Kessco X-188
| 8037-96-5 |
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| 8037-96-5 |
Ketene
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Ketipontrile, alpha,delta-diphenyl-
| 10471-29-1 |
Ketone, 1-adamantyldiazo methyl
| 5934-69-0 |
Ketone, 3-adamantyl hydroxymethyl
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Ketone, 3-adamantyl hydroxymethyl, oxime
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Ketone, 1-adamantyl(4-(o-methoxyphenyl)-1-piperazinyl)methyl,monohydrochloride
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Ketone, 1-adamantyl piperidinomethyl, hydrochloride
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Ketone, 2-amino-6-benzimidazolyl phenyl
| 52329-60-9 |
Ketone, 5-amino-1,3-dimethyl-4-pyrazolylo-fluorophenyl
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Ketone, 3-(2-aminoethyl)indol-5-yl methyl,hydrochloride
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Ketone, 4-amino-5-phenyl-3-pyrazolyl methyl
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Ketone, 4-amino-5-phenyl-3-pyrazolyl phenyl
| 91857-33-9 |
Ketone, (4-aminopiperidino)methyl indol-3-yl
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Ketone, 4-anilinopiperidino 2-phenylcyclopropyl,hydrochloride
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Ketone, 9-anthracenyl phenyl
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Ketone, 1-aziridinylm-(bis(2-chloroethyl)amino)phenyl
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Ketone, aziridinyl3-(bis(2-chloroethyl)amino)-p-tolyl, hydrate
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Ketone, 2-benzofuranyl methyl
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Ketone, benzo(b)thien-3-yl dimethylaminomethyl,hydrochloride
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Ketone, 3,4,5,6-benzo(c)thienyl methyl
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Janthinocin A
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Ketone, benzo(b)thien-3-yl morpholinomethyl,hydrochloride
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Ketone, benzo(b)thien-3-yl piperidinomethyl,hydrochloride
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