RTECS NUMBER : OO7340000
CHEMICAL NAME : Mandelic acid, alpha-cyclopentyl-,
1-methyl-3-pyrrolidinyl ester, hydrochloride
CAS REGISTRY NUMBER : 13118-10-0
LAST UPDATED : 198910
DATA ITEMS CITED : 3
MOLECULAR FORMULA : C18-H25-N-O3.Cl-H
MOLECULAR WEIGHT : 339.90
WISWESSER LINE NOTATION : T5NTJ A1 COVXQR&- AL5TJ &GH
COMPOUND DESCRIPTOR : Drug
Human
SYNONYMS/TRADE NAMES :
* AHR 376
* alpha-Cyclopentylmandelic acid 1-methyl-3-pyrrolidinyl ester
hydrochloride
* 1-Methyl-3-pyrrolidyl alpha-phenylcyclopentaneglycolate hydrochloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 14 ug/kg/D
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
Behavioral - toxic psychosis
REFERENCE :
CPAJAK Canadian Psychiatric Association Journal. (Ottawa, Ont., Canada)
V.1-23, 1956-78. For publisher information, see CJPSDF.
Volume(issue)/page/year: 11,S141,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC)
V.1-5, 1959-62. For publisher information, see JMCMAR.
Volume(issue)/page/year: 2,523,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 250 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC)
V.1-5, 1959-62. For publisher information, see JMCMAR.
Volume(issue)/page/year: 2,523,1960
*** END OF RECORD ***
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