*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : PA0650000
CHEMICAL NAME : Methanamine, N-((3-methyl-2-quinoxalinyl)methylene)-,
trioxide
CAS REGISTRY NUMBER : 32160-34-2
BEILSTEIN REFERENCE NO. : 0888258
REFERENCE : 5-24-03-00461 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 8
MOLECULAR FORMULA : C11-H11-N3-O3
MOLECULAR WEIGHT : 233.25
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* alpha-(1,4-Dioxido-3-methylquinoxalin-2-yl)-N-methylnitrone
* N-((3-Methyl-2-quinoxalinyl)methylene)methanamine trioxide
* alpha-(3-Methyl-2-quinoxalinyl)-N-methylnitrone 1,4-dioxide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 20,557,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 596 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 20,557,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 596 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 20,557,1977
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 4500 mg/kg/90D-I
TOXIC EFFECTS :
Endocrine - other changes
Endocrine - changes in adrenal weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 8,229,1981
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3500 mg/kg/35D-C
TOXIC EFFECTS :
Endocrine - hypoglycemia
Endocrine - changes in adrenal weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
JEPOEC Journal of Environmental Pathology, Toxicology and Oncology.
(Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984-
Volume(issue)/page/year: 6(5-6),109,1985
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4500 mg/kg/90D-C
TOXIC EFFECTS :
Endocrine - hypoglycemia
Endocrine - other changes
Endocrine - changes in adrenal weight
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 8,229,1981
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 4050 mg/kg/90D-I
TOXIC EFFECTS :
Endocrine - other changes
Related to Chronic Data - death
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 8,229,1981
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 1005 mg/kg/33D-I
TOXIC EFFECTS :
Endocrine - other changes
Related to Chronic Data - death
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 8,229,1981
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Mandelic acid, alpha-(1-cyclopentenyl)-,(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)methyl ester
| 101756-60-9 |
Methacrylic acid, diester with tetraethylene glycol
| 109-17-1 |
Methacrylic acid, diester with triethylene glycol
| 109-16-0 |
Methacrylic acid, 2-(diethylamino)ethyl ester
| 105-16-8 |
Methacrylic acid,2-(dimethylamino)-1-((dimethylamino)methyl)ethylester
| 21476-57-3 |
Methacrylic acid, 2-(dimethylamino)ethyl ester
| 2867-47-2 |
Methacrylic acid, dodecyl ester
| 142-90-5 |
Methacrylic acid, 2,3-epoxypropyl ester
| 106-91-2 |
Methacrylic acid, ester with ethyl glycolate
| 20363-83-1 |
Methacrylic acid, ester with hydracryonitrile
| 4513-53-5 |
Methacrylic acid, ester with isopropyl glycolate
| 23684-11-9 |
Mandelic acid, alpha-(1-cyclopentenyl)-,3-quinuclidinyl ester
| 101756-61-0 |
Methacrylic acid, polymer with ethyl acrylate
| 25212-88-8 |
Methacrylic acid, ethylene ester
| 97-90-5 |
Methacrylic acid, ethyl ester
| 97-63-2 |
Methacrylic acid, 2-ethylhexyl ester
| 688-84-6 |
Methacrylic acid, 2-(ethylthio)ethyl ester
| 14216-25-2 |
Methacrylic acid, 2-hydroxyethyl ester
| 868-77-9 |
Methacrylic acid, 2-hydroxypropyl ester
| 923-26-2 |
Methacrylic acid, isobutylene ester
| 63869-10-3 |
Methacrylic acid, isobutyl ester
| 97-86-9 |
Metharcylic acid, 2-isocyanatoethyl ester
| 30674-80-7 |
Mandelic acid, alpha-cyclopentyl-,(1-azabicyclo(2.2.2)oct-2-en-3-yl)methyl ester,hydrochloride
| 101710-75-2 |
Methacrylic acid, isodecyl ester
| 29964-84-9 |
Methacrylic acid, isopropyl ester
| 4655-34-9 |
Methacrylic acid, methyl ester
| 80-62-6 |
Methacrylic acid, methyl ester, polymer with butylacrylate and styrene
| 80-62-6 |
Methacrylic acid, methyl ester, polymer with methylacrylate
| 9011-87-4 |
Methacrylic acid, nitrilotriethylene ester
| 13884-43-0 |
Methacrylic acid, 2-piperidinoethyl ester
| 19416-48-9 |
Methacrylic acid, polymer withN-(beta-hydroxy-alpha-methylphenethyl)-N-methylmethacrylamide
| 19416-48-9 |
Methacrylic acid, polymer with methyl methacrylate,sodium monoethanolamine salt
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Methacrylic acid, polymer with methyl methacrylate,sodium salt
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Mandelic acid, alpha-cyclopentyl-,1-benzyl-3-pyrrolidinyl ester
| 101710-76-3 |
Methacrylic acid, polymer with(+-)-N-(alpha-methylphenethyl)methacrylamide
| 101710-76-3 |
Methacrylic acid, polymer withN-phenethylmethacrylamide
| 37129-92-3 |
Methacrylic acid, propyl ester
| 2210-28-8 |
Methacrylic acid, 2-(vinyloxy)ethyl ester
| 1464-69-3 |
Methacrylic anhydride
| 760-93-0 |
Methacryloyl chloride
| 920-46-7 |
alpha-dl-Methadol
| 63869-11-4 |
Methanamine, N,N-dimethyl-
| 75-50-3 |
Methanamine, N,N-dimethyl-, compd. with borane (11)
| 75-22-9 |
Methanamine,N-(3,7-dimethyl-9-2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatraenylid ene)-, N-oxide, (all-E)-
| 126924-36-5 |
Mandelic acid, alpha-cyclopentyl-,1-butyl-3-pyrrolidinyl ester, hydrochloride
| 101710-77-4 |
Methanamine,N-(3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8- nonatetraenylidene)-, N-oxide, (Z,E,E,E,E)-
| 91488-26-5 |
Methanamine,N-(hexahydro-1-phenyl-3H-oxazolo(3,4-a)pyridin-3-ylidene)-1-methoxy-, trans-(+-)-
| 91488-26-5 |
Methanamine, hydrochloride
| 593-51-1 |
Methanamine,N-(3-(1-methyl-2-nitro-1H-imidazol-5-yl)-2-propenylidene)-, N-oxide, (E)-
| 62143-83-3 |
Methanamine, N-((3-methyl-2-quinoxalinyl)methylene)-,trioxide
| 32160-34-2 |
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