*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : OZ4725000
CHEMICAL NAME : Methacrylic acid, 2-hydroxyethyl ester
CAS REGISTRY NUMBER : 868-77-9
BEILSTEIN REFERENCE NO. : 1071583
REFERENCE : 4-02-00-01530 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 18
MOLECULAR FORMULA : C6-H10-O3
MOLECULAR WEIGHT : 130.16
WISWESSER LINE NOTATION : Q2OVY1&U1
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Ethylene glycol methacrylate
* Ethylene glycol, monomethacrylate
* Glycol methacrylate
* Glycol monomethacrylate
* Hydroxyethyl methacrylate
* beta-Hydroxyethyl methacrylate
* 2-Hydroxyethyl methacrylate
* Mhoromer
* Monomer MG-1
* Monomethacrylic ether of ethylene glycol
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5050 mg/kg
TOXIC EFFECTS :
Behavioral - coma
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 54(9),75,1989
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de
Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946-
Volume(issue)/page/year: 36,58,1975
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 3275 mg/kg
TOXIC EFFECTS :
Behavioral - coma
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 54(9),75,1989
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 497 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 62,778,1973
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 99200 nL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 63,376,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 4680 mg/kg
TOXIC EFFECTS :
Behavioral - coma
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 54(9),75,1989
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 612 mg/kg/35W-I
TOXIC EFFECTS :
Liver - other changes
Blood - changes in spleen
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 52(11),81,1987
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2850 mg/kg/30D-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Blood - changes in leukocyte (WBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other transferases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 54(9),75,1989
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 3062 mg/kg
SEX/DURATION : female 35 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 52(11),81,1987
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 3062 mg/kg
SEX/DURATION : male 35 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 52(11),81,1987
*** REVIEWS ***
TOXICOLOGY REVIEW
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
Volume(issue)/page/year: 11,141,1975
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-THE NETHERLANDS:.TWA 04 ppm. (24 mg/m3) JAN 1993
OEL-RUSSIA:STEL 20 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - A1338
No. of Facilities: 158 (estimated)
No. of Industries: 5
No. of Occupations: 8
No. of Employees: 2245 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - A1338
No. of Facilities: 420 (estimated)
No. of Industries: 17
No. of Occupations: 20
No. of Employees: 16031 (estimated)
No. of Female Employees: 5273 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
47,26992,82
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Mandelic acid, alpha-(1-cyclopentenyl)-,(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)methyl ester
| 101756-60-9 |
Methacrylic acid, diester with tetraethylene glycol
| 109-17-1 |
Methacrylic acid, diester with triethylene glycol
| 109-16-0 |
Methacrylic acid, 2-(diethylamino)ethyl ester
| 105-16-8 |
Methacrylic acid,2-(dimethylamino)-1-((dimethylamino)methyl)ethylester
| 21476-57-3 |
Methacrylic acid, 2-(dimethylamino)ethyl ester
| 2867-47-2 |
Methacrylic acid, dodecyl ester
| 142-90-5 |
Methacrylic acid, 2,3-epoxypropyl ester
| 106-91-2 |
Methacrylic acid, ester with ethyl glycolate
| 20363-83-1 |
Methacrylic acid, ester with hydracryonitrile
| 4513-53-5 |
Methacrylic acid, ester with isopropyl glycolate
| 23684-11-9 |
Mandelic acid, alpha-(1-cyclopentenyl)-,3-quinuclidinyl ester
| 101756-61-0 |
Methacrylic acid, polymer with ethyl acrylate
| 25212-88-8 |
Methacrylic acid, ethylene ester
| 97-90-5 |
Methacrylic acid, ethyl ester
| 97-63-2 |
Methacrylic acid, 2-ethylhexyl ester
| 688-84-6 |
Methacrylic acid, 2-(ethylthio)ethyl ester
| 14216-25-2 |
Methacrylic acid, 2-hydroxyethyl ester
| 868-77-9 |
Methacrylic acid, 2-hydroxypropyl ester
| 923-26-2 |
Methacrylic acid, isobutylene ester
| 63869-10-3 |
Methacrylic acid, isobutyl ester
| 97-86-9 |
Metharcylic acid, 2-isocyanatoethyl ester
| 30674-80-7 |
Mandelic acid, alpha-cyclopentyl-,(1-azabicyclo(2.2.2)oct-2-en-3-yl)methyl ester,hydrochloride
| 101710-75-2 |
Methacrylic acid, isodecyl ester
| 29964-84-9 |
Methacrylic acid, isopropyl ester
| 4655-34-9 |
Methacrylic acid, methyl ester
| 80-62-6 |
Methacrylic acid, methyl ester, polymer with butylacrylate and styrene
| 80-62-6 |
Methacrylic acid, methyl ester, polymer with methylacrylate
| 9011-87-4 |
Methacrylic acid, nitrilotriethylene ester
| 13884-43-0 |
Methacrylic acid, 2-piperidinoethyl ester
| 19416-48-9 |
Methacrylic acid, polymer withN-(beta-hydroxy-alpha-methylphenethyl)-N-methylmethacrylamide
| 19416-48-9 |
Methacrylic acid, polymer with methyl methacrylate,sodium monoethanolamine salt
| 82153-85-3 |
Methacrylic acid, polymer with methyl methacrylate,sodium salt
| 26950-79-8 |
Mandelic acid, alpha-cyclopentyl-,1-benzyl-3-pyrrolidinyl ester
| 101710-76-3 |
Methacrylic acid, polymer with(+-)-N-(alpha-methylphenethyl)methacrylamide
| 101710-76-3 |
Methacrylic acid, polymer withN-phenethylmethacrylamide
| 37129-92-3 |
Methacrylic acid, propyl ester
| 2210-28-8 |
Methacrylic acid, 2-(vinyloxy)ethyl ester
| 1464-69-3 |
Methacrylic anhydride
| 760-93-0 |
Methacryloyl chloride
| 920-46-7 |
alpha-dl-Methadol
| 63869-11-4 |
Methanamine, N,N-dimethyl-
| 75-50-3 |
Methanamine, N,N-dimethyl-, compd. with borane (11)
| 75-22-9 |
Methanamine,N-(3,7-dimethyl-9-2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatraenylid ene)-, N-oxide, (all-E)-
| 126924-36-5 |
Mandelic acid, alpha-cyclopentyl-,1-butyl-3-pyrrolidinyl ester, hydrochloride
| 101710-77-4 |
Methanamine,N-(3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8- nonatetraenylidene)-, N-oxide, (Z,E,E,E,E)-
| 91488-26-5 |
Methanamine,N-(hexahydro-1-phenyl-3H-oxazolo(3,4-a)pyridin-3-ylidene)-1-methoxy-, trans-(+-)-
| 91488-26-5 |
Methanamine, hydrochloride
| 593-51-1 |
Methanamine,N-(3-(1-methyl-2-nitro-1H-imidazol-5-yl)-2-propenylidene)-, N-oxide, (E)-
| 62143-83-3 |
Methanamine, N-((3-methyl-2-quinoxalinyl)methylene)-,trioxide
| 32160-34-2 |
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