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MSDS  : Methanol, (methyl-ONN-azoxy)-
CAS  : 590-96-5
SYNONYMS  : * 1-Hydroxymethyl-2-methylditmide-2-oxide * Methylazoxymethanol
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : PC2625000
CHEMICAL NAME : Methanol, (methyl-ONN-azoxy)-
CAS REGISTRY NUMBER : 590-96-5
BEILSTEIN REFERENCE NO. : 1921057
LAST UPDATED : 199709
DATA ITEMS CITED : 35
MOLECULAR FORMULA : C2-H6-N2-O2
MOLECULAR WEIGHT : 90.10
WISWESSER LINE NOTATION : Q1NUNO&1
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* 1-Hydroxymethyl-2-methylditmide-2-oxide
* Methylazoxymethanol

*** HEALTH HAZARD DATA ***

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 50 mg/kg/2W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 12,335,1991

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 234 mg/kg/39W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
REFERENCE :
DICRAG Diseases of the Colon and Rectum. (Lippincott/Harper, Journal
Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1958-
Volume(issue)/page/year: 16,438,1973

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 10 mg/kg/9W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
Liver - tumors
REFERENCE :
25NJAN "International Cancer Congress, Abstracts, 10th, Houston, TX, 1970,"
Cumley, R.W., and J.E. McCay, eds., Chicago, IL, Year Book Medical Pub.,
Inc., 1970 Volume(issue)/page/year: -,24,1970

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 1800 ug/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
Liver - tumors
REFERENCE :
25NJAN "International Cancer Congress, Abstracts, 10th, Houston, TX, 1970,"
Cumley, R.W., and J.E. McCay, eds., Chicago, IL, Year Book Medical Pub.,
Inc., 1970 Volume(issue)/page/year: -,24,1970

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 20 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - colon tumors
Liver - tumors
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
Volume(issue)/page/year: 10,86,1969

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 80 mg/kg/35W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - colon tumors
REFERENCE :
APAVAY Virchows Archiv fuer Pathologische, Anatomie und Physiologie, und
fuer Klinische Medizin. (Berlin, Ger.) V.1-343, 1847-1967. For publisher
information, see VAAPB7. Volume(issue)/page/year: 340,151,1965

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 18 mg/kg/3W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
Liver - tumors
REFERENCE :
25NJAN "International Cancer Congress, Abstracts, 10th, Houston, TX, 1970,"
Cumley, R.W., and J.E. McCay, eds., Chicago, IL, Year Book Medical Pub.,
Inc., 1970 Volume(issue)/page/year: -,24,1970

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 20 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
IGKEAO Igaku Kenkyu. Medical Research. (Daido Gakkan Shuppanbu, Kyushu
Daigaku Igakubu, Hoigaku Kyoshitsu, Fukuoka 812, Japan) V.1- 1927-
Volume(issue)/page/year: 44,211,1974

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 50 mg/kg/2W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 6,1529,1985

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 20 mg/kg/2W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
Liver - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60,
1940-78. For publisher information, see JJIND8. Volume(issue)/page/year:
37,217,1966

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 50 mg/kg/2W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
REFERENCE :
NUCADQ Nutrition and Cancer. (Franklin Institute Press, POB 2266,
Phildelphia, PA 19103) V.1- 1978- Volume(issue)/page/year: 15,229,1991

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 14 mg/kg
SEX/DURATION : female 15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 25(2),42A,1982

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 20 mg/kg
SEX/DURATION : female 15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - hepatobiliary system
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 1(2),114,1976

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 20 mg/kg
SEX/DURATION : female 14-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
163,88,1969

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 20 mg/kg
SEX/DURATION : female 15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
NDKIA2 Kankyo Igaku Kenkyusho Nenpo (Nagoya Daigaku). Annual Report of the
Research Institute of Environmental Medicine, Nagoya University. (Nagoya
Daigaku Kankyo Igaku Kenkyusho, Furo-cho, Chikosa-ku, Nagoya 464, Japan)
V.1- 1949- Volume(issue)/page/year: 33,299,1982

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE : 45 mg/kg
SEX/DURATION : female 11-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Effects on Newborn - behavioral
REFERENCE :
NERADN Neuroscience Research (Shannon, Ireland). (Elsevier Scientific
Publishers Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1984-
Volume(issue)/page/year: 11,209,1991

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE : 20 mg/kg
SEX/DURATION : female 14-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
XENOBH Xenobiotica. (Taylor & Francis Ltd., 4 John St., London WC1N 2ET,
UK) V.1- 1971- Volume(issue)/page/year: 3,271,1973

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - hamster
DOSE : 20 mg/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 124,476,1967

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - hamster
DOSE : 23 mg/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 124,476,1967

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - hamster
DOSE : 25 mg/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 124,476,1967

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 10 umol/plate
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
39,3780,1979

TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 90 ng
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 125,988,1967

TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 1350 nmol/plate
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
47,5939,1987

TYPE OF TEST : Host-mediated assay
TEST SYSTEM : Rodent - mouse Bacteria - Salmonella typhimurium
DOSE/DURATION : 1200 mg/kg
REFERENCE :
22XWAN "Chemical Mutagenesis in Mammals and Man," Vogel, F., and G.
Roehrborn, eds., Berlin, Fed. Rep. Ger., Springer, 1970
Volume(issue)/page/year: -,260,1970

TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 2500 ug/L
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 235,278,1972

TYPE OF TEST : DNA damage
TEST SYSTEM : Mammal - species unspecified Lymphocyte
DOSE/DURATION : 1 mol/L
REFERENCE :
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce
Way, Colchester, Essex CO2 8HP, UK) V.1- 1906- Volume(issue)/page/year:
98,20c,1966

*** REVIEWS ***

IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 10,121,1976

IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 10,121,1976

IARC Cancer Review:Group 2B
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987

TOXICOLOGY REVIEW
PRNPAM Progress in Neuropathology. (New York, NY) V.1-5, 1971-82.
Discontinued. Volume(issue)/page/year: 2,91,1973

TOXICOLOGY REVIEW
85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer
Congress," Chicago, Year Book Medical Pub., 1971 Volume(issue)/page/year:
5,196,1970

TOXICOLOGY REVIEW
CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For
publisher information, see JNCIEQ. Volume(issue)/page/year: 60,1171,1976

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal
assay

EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal

EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
4,7-Methano-1H-isoindole-1,3(2H)-dione,3a,4,7,7a-tetrahydro-2-(4-(2-propynyloxy)phenyl)- 39488-06-7
4,7-Methano-1H-isoindole-1,3(2H)-dione,3a,4,7,7a-tetrahydro-2-(4-(1-pyrrolidinyl)-2-butynyl)-, monohydrochloride 39488-11-4
4,7-Methanoisoindole-2-ethanol, 4,7-dihydro- 78593-81-4
4,7-Methanoisoindole-2-ethanol, 4,5,6,7-tetrahydro- 63023-85-8
Methanearsonic acid, compd. with2,2',2''-nitrilotriethanol 5902-97-6
Methaneperoxic acid 107-32-4
4,7-Methanoisoindole,4,5,6,7-tetrahydro-2-tert-butyl- 78593-85-8
4,7-Methanoisoindole, 4,5,6,7-tetrahydro-2-phenyl- 78593-82-5
4,7-Methanoisoindole, 4,5,6,7-tetrahydro-2-(p-tolyl)- 30451-37-7
4,7-Methanoisoindoline,3a,7a-dihydro-2-(diethylaminoethyl)- 74037-58-4
4,7-Methanoisoindoline,3a,7a-dihydro-2-(3-morpholinopropyl)- 73855-76-2
4,7-Methanoisoindoline-2-ethanol, hexahydro- 63023-83-6
4,7-Methanoisoindoline, hexahydro-2-tert-butyl- 78593-87-0
4,7-Methanoisoindoline, hexahydro-2-phenyl- 78593-86-9
4,7-Methanoisoindoline, 3a,4,7,7a-tetrahydro-,hydrochloride 15997-94-1
4,7-Methanoisoindolinium,3a,7a-dihydro-2-(2-(diethylmethylammonio)ethyl)-2-methyl-, diiodide 74051-64-2
Methanesulfenyl chloride, dichlorofluoro- 2712-93-8
4,7-Methanoisoindolinium,3a,7a-dihydro-2-methyl-2-(3-(4-methyl-4-morpholinio)propyl)-, diiodide 74037-59-5
Methanol 67-56-1
Methanol, benzoyl-, compd with morpholine acetate 67-56-1
Methanol, (benzylnitrosamino)-, acetate (ester) 63531-81-7
Methanol,(4,6-bis(bis(butoxymethyl)amino)-s-triazin-2-ylimino)di- 74037-60-8
Methanol,((6-bis(2-chloroethoxymethyl)amino)-s-triazine-2,4-diyl)(N,N'-bis(2-chloro ethoxy methyldinitrilo))di- 74037-61-9
Methanol, bis(p-chlorophenyl)cyclopropyl- 14088-71-2
Methanol,((4,6-bis(dimethylamino)-s-triazin-2-yl)methylamino)- 16269-01-5
Methanol,((6-bis(1-hydroxy-2-propenyl)amino)-s-triazine-2,4-diyl)dinitrilotetra- 74037-62-0
Methanol, (butyldimethylsilyl)-, carbamate 3124-39-8
Methanesulfenyl chloride, trichloro- 594-42-3
Methanol, (tert-butyldioxy)- 17742-78-8
Methanol, (butylmethylsilylene)di-, dicarbamate(ester) 3124-49-0
Methanol, (butylnitrosoamino)- 76671-53-9
Methanol,(5-chloro-3-(5-chloro-2-hydroxybenzyl)-2-hydroxyphenyl)- 76671-53-9
Methanol, cyclohexylphenyl- 945-49-3
Methanol, cyclopropyldiphenyl- 5785-66-0
Methanol, compd. with(+-)-alpha-(2-dimethylamino)-1-methylethyl-alpha-phenylphenethyl propionate (1:1) 2621-61-6
Methanol, (dimethylethylsilyl)-, carbamate 2621-61-6
Methanol, (dimethylphosphino)- 33796-25-7
Methanol, (dimethylpropylsilyl)-, carbamate 3124-41-2
Methanesulfinic acid, 1-(p-butoxyanilino)-, sodiumsalt 3124-41-2
Methanol, diphenyl(2-(4-pyridyl)cyclopropyl)-, (E)- 4904-00-1
Methanol, diphenyl(2-(4-pyridyl)cyclopropyl)-,hydrochloride 2364-72-9
Methanol, (1,2-ethanediylbis(nitroimino))bis-,diacetate (ester) 14168-48-0
Methanol, (ethylnitrosoamino)- 86860-62-0
Methanol, methoxy-ONN-azoxy-, acetate (ester) 67293-86-1
Methanol, (methyl-ONN-azoxy)- 590-96-5
Methanol, (methyl-ONN-azoxy)-, acetate (ester) 592-62-1
Methanol, (methylazoxy)-, benzoate (ester) 3527-05-7
Methanol,methyl-3-cyclohexenyl 17264-01-6
Methanol, (methylnitramino)- 32818-80-7
Methanesulfinic acid, 1-((6-butoxy-3-pyridyl)amino)-,sodium salt 32818-80-7

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