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MSDS  : 1,3,4-Metheno-2H-cyclobuta(cd)pentalen-2-one, 1,1a,3,3a,4,5,5,5a,5b,6-decachloroctahydro-
CAS  : 143-50-0
SYNONYMS  : * Ciba 8514 * Chlordecone * Clordecone * Compound 1189 * 1,2,3,5,6,7,8,9,10,10-Decachloro(5.2.1.0(sup 2,6).0(sup 3,9).0(sup 5,8))decano-4-one * Decachloroketone * Decachloro-1,3,4-metheno-2H-cyclobuta(cd)pentalen-2-one * Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta(cd)pentalen-2-one * 1,1a,3,3a,4,5,5,5a,5b,6-Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta(c d)pentalen-2-one * Decachloropentacyclo(5.2.1.0(sup 2,6).0(sup 3,9).0(sup 5,8))decan-4-one * Decachloropentacyclo(5.3.0.0(sup 2,6).0(sup 4,10).0(sup 5,9))decan-3-one * Decachlorotetracyclodecanone * Decachlorotetrahydro-4,7-methanoindeneone * ENT 16,391 * GC 1189 * General chemicals 1189 * Kepone * NCI-C00191 * RCRA waste number U142
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : PC8575000
CHEMICAL NAME : 1,3,4-Metheno-2H-cyclobuta(cd)pentalen-2-one,
1,1a,3,3a,4,5,5,5a,5b,6-decachloroctahydro-
CAS REGISTRY NUMBER : 143-50-0
LAST UPDATED : 199710
DATA ITEMS CITED : 61
MOLECULAR FORMULA : C10-Cl10-O
MOLECULAR WEIGHT : 490.60
WISWESSER LINE NOTATION : L545 BH C5 D 4ABCE J DVTJ AG BG CG EG FG GG HG HG IG
JG
COMPOUND DESCRIPTOR : Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Ciba 8514
* Chlordecone
* Clordecone
* Compound 1189
* 1,2,3,5,6,7,8,9,10,10-Decachloro(5.2.1.0(sup 2,6).0(sup 3,9).0(sup
5,8))decano-4-one
* Decachloroketone
* Decachloro-1,3,4-metheno-2H-cyclobuta(cd)pentalen-2-one
* Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta(cd)pentalen-2-one
* 1,1a,3,3a,4,5,5,5a,5b,6-Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta(c
d)pentalen-2-one
* Decachloropentacyclo(5.2.1.0(sup 2,6).0(sup 3,9).0(sup 5,8))decan-4-one
* Decachloropentacyclo(5.3.0.0(sup 2,6).0(sup 4,10).0(sup 5,9))decan-3-one
* Decachlorotetracyclodecanone
* Decachlorotetrahydro-4,7-methanoindeneone
* ENT 16,391
* GC 1189
* General chemicals 1189
* Kepone
* NCI-C00191
* RCRA waste number U142

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 91300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
5,91,1983

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
14,515,1969

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 250 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
45,331,1978

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 65 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,642,1966

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 345 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada,
171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year: 6,96,1973

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - quail
DOSE/DURATION : 237 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 48,371,1976

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 126 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag
New York, Inc., 1971 Volume(issue)/page/year: -,65,1971

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 307 mg/kg/15W-I
TOXIC EFFECTS :
Behavioral - alteration of operant conditioning
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
5,91,1983

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 912 mg/kg/2Y-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
48,29,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 100 mg/kg/10D-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Blood - changes in other cell count (unspecified)
Immunological Including Allergic - decreased immune response
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 15,561,1985

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 162 mg/kg/90D-C
TOXIC EFFECTS :
Biochemical - Neurotransmitters or modulators (putative) - dopamine in
striatum
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
59,262,1981

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 287 mg/kg/35D-C
TOXIC EFFECTS :
Liver - other changes
Liver - changes in liver weight
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
58,132,1981

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 75 mg/kg/3D-I
TOXIC EFFECTS :
Behavioral - tremor
Musculoskeletal - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
07094) V.1- 1966- Volume(issue)/page/year: 25,262,1980

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 12500 ug/kg/5D-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
etc.)
REFERENCE :
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1971- Volume(issue)/page/year:
18,113,1982

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 180 mg/kg/18D-I
TOXIC EFFECTS :
Behavioral - ataxia
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR
72203) V.1- 1979- Volume(issue)/page/year: 2,113,1981

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 150 mg/kg/3D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Behavioral - tremor
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 6,275,1980

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 320 mg/kg/10W-I
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
07094) V.1- 1966- Volume(issue)/page/year: 39,615,1987

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 560 mg/kg/2.5Y-C
TOXIC EFFECTS :
Cardiac - changes in heart weight
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
48,29,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - quail
DOSE/DURATION : 1470 mg/kg/42D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Related to Chronic Data - death
Related to Chronic Data - changes in testicular weight
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
43,535,1978

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 200 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4-
1957- Volume(issue)/page/year: 26,231,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1200 mg/kg/80W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-b,1976

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 670 mg/kg/80W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-b,1976

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1340 mg/kg/80W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
37,680,1976

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1550 mg/kg/80W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
37,680,1976

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 63 mg/kg
SEX/DURATION : female 2-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 4,247,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 42 mg/kg
SEX/DURATION : female 2-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
41,142,1977

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 100 mg/kg
SEX/DURATION : female 7-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - urogenital system
Reproductive - Specific Developmental Abnormalities - homeostasis
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
38,189,1976

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 60 mg/kg
SEX/DURATION : female 7-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
38,189,1976

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 17 mg/kg
SEX/DURATION : female 1-22 day(s) after conception
lactating female 12 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 40,667,1981

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 18 mg/kg
SEX/DURATION : male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 30,237,1986

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 25 mg/kg
SEX/DURATION : female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
REFERENCE :
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year:
5,65,1991

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 50 mg/kg
SEX/DURATION : female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
Reproductive - Fertility - mating performance (e.g. # sperm positive females
per # females mated; # copulations per # estrus cycles)
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
8,121,1986

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 50 mg/kg
SEX/DURATION : female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
REFERENCE :
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year:
1,105,1987/1988

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 75 mg/kg
SEX/DURATION : female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year:
5,65,1991

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 2 mg/kg
SEX/DURATION : female 2 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 16,131,1978

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 10 mg/kg
SEX/DURATION : female 2 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 16,131,1978

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 16500 ug/kg
SEX/DURATION : male 4 week(s) pre-mating
female 4 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
JEENAI Journal of Economic Entomology. (Entomological Soc. of America, 4603
Calvert Rd., College Park, MD 20740) V.1- 1908- Volume(issue)/page/year:
58,754,1965

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 120 mg/kg
SEX/DURATION : female 7-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
38,189,1976

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 100 mg/kg
SEX/DURATION : female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 10,541,1982

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 120 mg/kg
SEX/DURATION : female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth)
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
per # born alive)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year:
6,361,1986

** MUTATION DATA **

TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 100 umol/L
REFERENCE :
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview
Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 4,179,1990

TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 1700 ug/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
10(Suppl 10),1,1987

TYPE OF TEST : Sperm Morphology
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Bird - quail
DOSE/DURATION : 200 ppm/42D (Continuous)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
43,535,1978

*** REVIEWS ***

IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 20,67,1979

IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 20,67,1979

IARC Cancer Review:Group 2B
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987

TOXICOLOGY REVIEW
STEVA8 Science of the Total Environment. (Elsevier Science Pub. B.V., POB
211, 1000 AE Amsterdam, Netherlands) V.1- 1972- Volume(issue)/page/year:
9,1,1978

TOXICOLOGY REVIEW
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 4,895,1978

TOXICOLOGY REVIEW
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher
information, see JTCTDW. Volume(issue)/page/year: 13,231,1978

TOXICOLOGY REVIEW
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest
South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
Volume(issue)/page/year: 2(3),671,1979

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-FRANCE;Carcinogen JAN 1993

OEL-GERMANY;Carcinogen JAN 1993

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO KEPONE-air:10H CA TWA 0.001 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M2969
No. of Facilities: 280 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 12600 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat

EPA GENETOX PROGRAM 1988, Inconclusive: Sperm morphology-human

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8899

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

NIOSH Analytical Method, 1994: Kepone, 5508

NTP 7th Annual Report on Carcinogens, 1992 : anticipated to be carcinogen


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Methanone,(2-(((methylaminocarbonyl)oxy)phenyl)phenyl)-,O-((methylamino)carbonyl)oxime 52174-16-0
Methanone,(3-(((methylaminocarbonyl)oxy)phenyl)phenyl)-,O-((methylamino)carbonyl)oxime 52174-17-1
Methanone,(2-(1-methylethyl-1H-indol-3-yl)-3-pyridinyl)- 36504-64-0
Methanone,(1-methyl-1H-indol-3-yl)(4,5,6,7-tetrahydro-1H-benzimidazol-5-yl)-, monohydrochloride, (R)- 132907-72-3
Methanone,(1-methyl-2-(1-methylethyl)-1H-indol-3-yl)-3-pyridinyl- 54270-10-9
Methanone,(2-methylphenyl)(5-methyl-2-(beta-D-xylopyranosyloxy)phenyl)- 83355-19-5
Methanone,(2-methylphenyl)(3-(beta-D-xylopyranosyloxy)phenyl)- 83355-11-7
Methanone,(4-methylphenyl)(3-(beta-D-xylopyranosyloxy)phenyl)- 83355-08-2
Methanone,(4-methylphenyl)(4-(beta-D-xylopyranosyloxy)phenyl)-,hydrate 83354-79-4
Methanone,(2-(4-morpholinyl)-2H-1-benzopyran-3-yl)phenyl- 122438-01-1
Methanone, (3-bromophenyl)-2-dibenzothienyl- 98257-48-8
Methanone,(3-(4-morpholinyl)-3H-naphtho(2,1-b)pyran-2-yl)phenyl- 122438-10-2
Methanone,(2-(4-morpholinyl)-6-nitro-2H-1-benzopyran-3-yl)phenyl- 122438-06-6
Methanone,(3-nitrophenyl)(4-(beta-D-xylopyranosyloxy)phenyl)- 83354-70-5
Methanone,(4-nitrophenyl)(3-(beta-D-xylopyranosyloxy)phenyl)- 83355-06-0
Methanone,(4-nitrophenyl)(4-(alpha-D-xylopyranosyloxy)phenyl)- 147029-72-9
Methanone,(4-nitrophenyl)(4-(beta-D-xylopyranosyloxy)phenyl)- 83354-69-2
Methanone,(2,3,5,6,8,9,11,12-octahydro-1,4,7,10,13-benzopentaoxacyclopentadecin-15-y l)phenyl- 87251-56-7
Methanone, 1,4-phenylenebis((4-methylphenyl)- 87251-56-7
Methanone,phenyl(4-(3-(4-phenyl-1-piperazinyl)propoxy)phenyl)- 65976-21-8
Methanone,phenyl(4-((2-(1-piperazinyl)-4-thiazolyl)methyl)phenyl)-, hydrochloride, hydrate (2:4:1) 73553-73-8
Methanone,(4-bromophenyl)(2,3-dihydro-1,4-benzodioxin-6-yl)- 101018-99-9
Methanone,phenyl(6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-,O-(2-(dimethylamino)ethyl) oxime, monohydrochloride 51490-40-5
Methanone,phenyl(6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-,O-(3-(dimethylamino)propyl) oxime, hydrochloride,hydrate (2:2:1) 51490-41-6
Methanone,phenyl(2,3,4,5-tetrahydro-1-benzoxepin-7-yl)- 147394-48-7
Methanone, phenyl(3-(beta-D-xylopyranosyloxy)phenyl)- 83355-05-9
Methanone, phenyl(4-(beta-D-xylopyranosyloxy)phenyl)- 83354-85-2
Methanone,phenyl(2-((2-thienylmethylene)amino)phenyl)- 41242-38-0
Methanone,(4-(trifluoromethyl)phenyl)(4-(beta-D-xylopyranosyloxy)phenyl)- 83354-78-3
Methanone,(2,3,4-trihydroxyphenyl)(3,4,5-trihydroxyphenyl)- 52479-85-3
3b-beta,6-Methano-36H-oxireno(3',4')cyclopenta(1',2'3,4)heptaleno(1,2-d)- 1,3-dioxole-5,9,11a-alpha(4H)-triol,3a-alpha,5,6-alpha,7,8,8a-alpha,9,9a-alpha,9b-beta,10a-beta,11,11b-beta-dodecahydro-2,2,5-alpha,9-alpha,11,11-hexamethyl- 28836-76-2
4H-9,11a-Methanooxireno(3',4')cyclopenta(1',2'3,4)heptaleno(2,3-d)-1,3-di oxol-12(12aH)-one,decahydro-6,10-dihydroxy-2,2,4,4,6,10-hexamethyl-,(4aR-(3aR*,4a-alpha,5a-alpha,5b-alpha,6-alpha,6a-beta,9-alpha,10-alpha,11a-alpha,12a-alpha))- 35356-26-4
Methanone,(2-butyl-3-benzofuranyl)(4-(2-(ethylamino)ethoxy)-3,5-diiodophenyl)- 83409-32-9
6,9-Methano-8H-pyrido(1',2'1,2)azepino(4,5-b)indole-6(6ah)-carboxylic acid, 7,8,9,10,12,13-hexahydro-6-ethyl-13a-hydroxy-, methyl ester,hydrochloride 4503-12-2
4,7-Methanoselenophene,octahydro-2,2,3,3-tetrafluoro- 102489-70-3
3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-,(1aR-(1a-alpha,2a-beta,3-beta,6-beta,6a-beta,8as*,8b-beta,9R*))- 17617-45-7
1,3,4-Metheno-1H-cyclobuta(cd)pentalene,1,1a,2,2,3,3a,4,5,5,5a,5b,6- dodecachlorooctahydro- 2385-85-5
1,3,4-Metheno-1H-cyclobuta(c,d)-pentalene-2-levulinicacid, 1,1a,3,3a,4,5,5a,5b,6-decachlorooctahydro-2-hydroxy-, ethyl ester 4234-79-1
1,3,4-Metheno-1H-cyclobuta(cd)pentalene,1,1a,2,2,3,3a,4,5,5,5a,5-undecachlorooctahydro- 39801-14-4
1,3,4-Metheno-2H-cyclobuta(cd)pentalen-2-one,1,1a,3,3a,4,5,5,5a,5b,6-decachloroctahydro- 143-50-0
1,3,5-Methenocyclopenta(cd)pentalen-2-amine,decahydro-N-butyl-1-methyl-, hydrochloride,(1-alpha,2-alpha,2a-beta,3-alpha,4a-beta,5-alpha,6a-beta,6b-beta,7R*)-(+-)- 93660-80-1
1,3,5-Methenocyclopenta(cd)pentalen-2-amine,decahydro-N,1-diethyl-, hydrochloride,(1-alpha,2-alpha,2a-beta,3-alpha,4a-beta,5-alpha,6a-beta,6b-beta,7R*)-(+-)- 93660-80-1
1,3,5-Methenocyclopenta(cd)pentalen-2-amine,decahydro-N-ethyl-1-methyl-, hydrochloride,(1-alpha,2-alpha,2a-beta,3-alpha,4a-beta,5-alpha,6a-beta,6b-beta,7R*)-(+-)- 93660-75-4
Methanone,(5-chloro-2-(((4,5-dihydro-4-(4-ethoxyphenyl)-5-thioxo-1H-1,2,4-triazol-3- yl) methyl)amino)phenyl)phenyl- 111070-78-1
1,3,5-Methenocyclopenta(cd)pentalen-2-amine,decahydro-N-ethyl-1-phenyl-, hydrochloride,(1-alpha,2-beta,2a-alpha,3-beta,4a-alpha,5-beta,6a-alpha,6b-alpha,7S*)-(+- )- 111070-78-1
1,3,5-Methenocyclopenta(cd)pentalen-2-amine,decahydro-1-methyl-, hydrochloride,(1-alpha,2-alpha,2a-beta,3-alpha,4a-beta,5-alpha,6a-beta,6b-beta,7R*)-(+-)- 111070-78-1
1,3,5-Methenocyclopenta(cd)pentalen-2-amine,decahydro-1-methyl-N-(2-phenylethyl)-, hydrochloride,(1-alpha,2-alpha,2a-beta,3-alpha,4a-beta,5-alpha,6a-beta,6b-beta,7R*)-(+-)- 111070-78-1
1,3,5-Methenocyclopenta(cd)pentalen-2-amine,decahydro-1-methyl-N-(phenylmethyl)-, hydrochloride,(1-alpha,2-alpha,2a-beta,3-alpha,4a-beta,5-alpha,6a-beta,6b-beta,7R*)-(+-)- 111070-78-1
1,3,5-Methenocyclopenta(cd)pentalen-2-amine,decahydro-1-phenyl-, hydrochloride,(1-alpha,2-beta,2a-alpha,3-beta,4a-alpha,5-beta,6a-alpha,6b-alpha,7R*)-(+- )- 111070-78-1
2,4,7-Metheno-1H-cyclopenta(a)pentalene,1,1,2,3,3a,7a-hexachloro-5,6-epoxydecahydro-,stereoisomer 13366-73-9

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