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MSDS   | : | 6,9-Methano-8H-pyrido(1',2'1,2)azepino(4,5-b)indole-
6(6ah)-carboxylic acid, 7,8,9,10,12,13-
hexahydro-6-ethyl-13a-hydroxy-, methyl ester,
hydrochloride
| CAS   | : | 4503-12-2 | SYNONYMS   | : | * Coronaridine hydrochloride
* (-)-Coronaridine monohydrochloride
* Ibogamine-18-carboxylic acid, methyl ester, hydrochloride
* Ibogamine-18-carboxylic acid, methyl ester, monohydrochloride
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*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : PC5080000
CHEMICAL NAME : 6,9-Methano-8H-pyrido(1',2':1,2)azepino(4,5-b)indole-
6(6ah)-carboxylic acid, 7,8,9,10,12,13-
hexahydro-6-ethyl-13a-hydroxy-, methyl ester,
hydrochloride
CAS REGISTRY NUMBER : 4503-12-2
LAST UPDATED : 198910
DATA ITEMS CITED : 7
MOLECULAR FORMULA : C21-H26-N2-O2.Cl-H
MOLECULAR WEIGHT : 374.95
COMPOUND DESCRIPTOR : Reproductive Effector
SYNONYMS/TRADE NAMES :
* Coronaridine hydrochloride
* (-)-Coronaridine monohydrochloride
* Ibogamine-18-carboxylic acid, methyl ester, hydrochloride
* Ibogamine-18-carboxylic acid, methyl ester, monohydrochloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 52,598,1963
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 20 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
Gastrointestinal - nausea or vomiting
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 52,598,1963
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 10 mg/kg
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 52,598,1963
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 50 mg/kg
SEX/DURATION : female 10 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 62,1199,1973
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 30 mg/kg
SEX/DURATION : female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart
1, Fed. Rep. Ger.) V.1- 1953- Volume(issue)/page/year: 33,345,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 50 mg/kg
SEX/DURATION : female 10 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 62,1199,1973
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 30 mg/kg
SEX/DURATION : female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart
1, Fed. Rep. Ger.) V.1- 1953- Volume(issue)/page/year: 33,345,1978
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
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Methanone,(3-(((methylaminocarbonyl)oxy)phenyl)phenyl)-,O-((methylamino)carbonyl)oxime
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Methanone,(2-(1-methylethyl-1H-indol-3-yl)-3-pyridinyl)-
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Methanone,(1-methyl-1H-indol-3-yl)(4,5,6,7-tetrahydro-1H-benzimidazol-5-yl)-, monohydrochloride, (R)-
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Methanone,(1-methyl-2-(1-methylethyl)-1H-indol-3-yl)-3-pyridinyl-
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Methanone,(2-methylphenyl)(5-methyl-2-(beta-D-xylopyranosyloxy)phenyl)-
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Methanone,(2-methylphenyl)(3-(beta-D-xylopyranosyloxy)phenyl)-
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Methanone,(4-methylphenyl)(3-(beta-D-xylopyranosyloxy)phenyl)-
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Methanone,(4-methylphenyl)(4-(beta-D-xylopyranosyloxy)phenyl)-,hydrate
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Methanone,(2-(4-morpholinyl)-2H-1-benzopyran-3-yl)phenyl-
| 122438-01-1 |
Methanone, (3-bromophenyl)-2-dibenzothienyl-
| 98257-48-8 |
Methanone,(3-(4-morpholinyl)-3H-naphtho(2,1-b)pyran-2-yl)phenyl-
| 122438-10-2 |
Methanone,(2-(4-morpholinyl)-6-nitro-2H-1-benzopyran-3-yl)phenyl-
| 122438-06-6 |
Methanone,(3-nitrophenyl)(4-(beta-D-xylopyranosyloxy)phenyl)-
| 83354-70-5 |
Methanone,(4-nitrophenyl)(3-(beta-D-xylopyranosyloxy)phenyl)-
| 83355-06-0 |
Methanone,(4-nitrophenyl)(4-(alpha-D-xylopyranosyloxy)phenyl)-
| 147029-72-9 |
Methanone,(4-nitrophenyl)(4-(beta-D-xylopyranosyloxy)phenyl)-
| 83354-69-2 |
Methanone,(2,3,5,6,8,9,11,12-octahydro-1,4,7,10,13-benzopentaoxacyclopentadecin-15-y l)phenyl-
| 87251-56-7 |
Methanone, 1,4-phenylenebis((4-methylphenyl)-
| 87251-56-7 |
Methanone,phenyl(4-(3-(4-phenyl-1-piperazinyl)propoxy)phenyl)-
| 65976-21-8 |
Methanone,phenyl(4-((2-(1-piperazinyl)-4-thiazolyl)methyl)phenyl)-, hydrochloride, hydrate (2:4:1)
| 73553-73-8 |
Methanone,(4-bromophenyl)(2,3-dihydro-1,4-benzodioxin-6-yl)-
| 101018-99-9 |
Methanone,phenyl(6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-,O-(2-(dimethylamino)ethyl) oxime, monohydrochloride
| 51490-40-5 |
Methanone,phenyl(6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-,O-(3-(dimethylamino)propyl) oxime, hydrochloride,hydrate (2:2:1)
| 51490-41-6 |
Methanone,phenyl(2,3,4,5-tetrahydro-1-benzoxepin-7-yl)-
| 147394-48-7 |
Methanone, phenyl(3-(beta-D-xylopyranosyloxy)phenyl)-
| 83355-05-9 |
Methanone, phenyl(4-(beta-D-xylopyranosyloxy)phenyl)-
| 83354-85-2 |
Methanone,phenyl(2-((2-thienylmethylene)amino)phenyl)-
| 41242-38-0 |
Methanone,(4-(trifluoromethyl)phenyl)(4-(beta-D-xylopyranosyloxy)phenyl)-
| 83354-78-3 |
Methanone,(2,3,4-trihydroxyphenyl)(3,4,5-trihydroxyphenyl)-
| 52479-85-3 |
3b-beta,6-Methano-36H-oxireno(3',4')cyclopenta(1',2'3,4)heptaleno(1,2-d)- 1,3-dioxole-5,9,11a-alpha(4H)-triol,3a-alpha,5,6-alpha,7,8,8a-alpha,9,9a-alpha,9b-beta,10a-beta,11,11b-beta-dodecahydro-2,2,5-alpha,9-alpha,11,11-hexamethyl-
| 28836-76-2 |
4H-9,11a-Methanooxireno(3',4')cyclopenta(1',2'3,4)heptaleno(2,3-d)-1,3-di oxol-12(12aH)-one,decahydro-6,10-dihydroxy-2,2,4,4,6,10-hexamethyl-,(4aR-(3aR*,4a-alpha,5a-alpha,5b-alpha,6-alpha,6a-beta,9-alpha,10-alpha,11a-alpha,12a-alpha))-
| 35356-26-4 |
Methanone,(2-butyl-3-benzofuranyl)(4-(2-(ethylamino)ethoxy)-3,5-diiodophenyl)-
| 83409-32-9 |
6,9-Methano-8H-pyrido(1',2'1,2)azepino(4,5-b)indole-6(6ah)-carboxylic acid, 7,8,9,10,12,13-hexahydro-6-ethyl-13a-hydroxy-, methyl ester,hydrochloride
| 4503-12-2 |
4,7-Methanoselenophene,octahydro-2,2,3,3-tetrafluoro-
| 102489-70-3 |
3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-,(1aR-(1a-alpha,2a-beta,3-beta,6-beta,6a-beta,8as*,8b-beta,9R*))-
| 17617-45-7 |
1,3,4-Metheno-1H-cyclobuta(cd)pentalene,1,1a,2,2,3,3a,4,5,5,5a,5b,6- dodecachlorooctahydro-
| 2385-85-5 |
1,3,4-Metheno-1H-cyclobuta(c,d)-pentalene-2-levulinicacid, 1,1a,3,3a,4,5,5a,5b,6-decachlorooctahydro-2-hydroxy-, ethyl ester
| 4234-79-1 |
1,3,4-Metheno-1H-cyclobuta(cd)pentalene,1,1a,2,2,3,3a,4,5,5,5a,5-undecachlorooctahydro-
| 39801-14-4 |
1,3,4-Metheno-2H-cyclobuta(cd)pentalen-2-one,1,1a,3,3a,4,5,5,5a,5b,6-decachloroctahydro-
| 143-50-0 |
1,3,5-Methenocyclopenta(cd)pentalen-2-amine,decahydro-N-butyl-1-methyl-, hydrochloride,(1-alpha,2-alpha,2a-beta,3-alpha,4a-beta,5-alpha,6a-beta,6b-beta,7R*)-(+-)-
| 93660-80-1 |
1,3,5-Methenocyclopenta(cd)pentalen-2-amine,decahydro-N,1-diethyl-, hydrochloride,(1-alpha,2-alpha,2a-beta,3-alpha,4a-beta,5-alpha,6a-beta,6b-beta,7R*)-(+-)-
| 93660-80-1 |
1,3,5-Methenocyclopenta(cd)pentalen-2-amine,decahydro-N-ethyl-1-methyl-, hydrochloride,(1-alpha,2-alpha,2a-beta,3-alpha,4a-beta,5-alpha,6a-beta,6b-beta,7R*)-(+-)-
| 93660-75-4 |
Methanone,(5-chloro-2-(((4,5-dihydro-4-(4-ethoxyphenyl)-5-thioxo-1H-1,2,4-triazol-3- yl) methyl)amino)phenyl)phenyl-
| 111070-78-1 |
1,3,5-Methenocyclopenta(cd)pentalen-2-amine,decahydro-N-ethyl-1-phenyl-, hydrochloride,(1-alpha,2-beta,2a-alpha,3-beta,4a-alpha,5-beta,6a-alpha,6b-alpha,7S*)-(+- )-
| 111070-78-1 |
1,3,5-Methenocyclopenta(cd)pentalen-2-amine,decahydro-1-methyl-, hydrochloride,(1-alpha,2-alpha,2a-beta,3-alpha,4a-beta,5-alpha,6a-beta,6b-beta,7R*)-(+-)-
| 111070-78-1 |
1,3,5-Methenocyclopenta(cd)pentalen-2-amine,decahydro-1-methyl-N-(2-phenylethyl)-, hydrochloride,(1-alpha,2-alpha,2a-beta,3-alpha,4a-beta,5-alpha,6a-beta,6b-beta,7R*)-(+-)-
| 111070-78-1 |
1,3,5-Methenocyclopenta(cd)pentalen-2-amine,decahydro-1-methyl-N-(phenylmethyl)-, hydrochloride,(1-alpha,2-alpha,2a-beta,3-alpha,4a-beta,5-alpha,6a-beta,6b-beta,7R*)-(+-)-
| 111070-78-1 |
1,3,5-Methenocyclopenta(cd)pentalen-2-amine,decahydro-1-phenyl-, hydrochloride,(1-alpha,2-beta,2a-alpha,3-beta,4a-alpha,5-beta,6a-alpha,6b-alpha,7R*)-(+- )-
| 111070-78-1 |
2,4,7-Metheno-1H-cyclopenta(a)pentalene,1,1,2,3,3a,7a-hexachloro-5,6-epoxydecahydro-,stereoisomer
| 13366-73-9 |
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