*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : RA0780000
CHEMICAL NAME : Nitrous acid, butyl ester
CAS REGISTRY NUMBER : 544-16-1
BEILSTEIN REFERENCE NO. : 1701036
REFERENCE : 4-01-00-01523 (Beilstein Handbook Reference)
LAST UPDATED : 199709
DATA ITEMS CITED : 11
MOLECULAR FORMULA : C4-H9-N-O2
MOLECULAR WEIGHT : 103.14
WISWESSER LINE NOTATION : ONO4
COMPOUND DESCRIPTOR : Mutagen
Human
SYNONYMS/TRADE NAMES :
* Butyl nitrite
* n-Butyl nitrite
* NCI-C56553
* Nitrous acid, n-butyl ester
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 153 mg/kg
TOXIC EFFECTS :
Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200
Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year:
92,570,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 83 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
Behavioral - rigidity (including catalepsy)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
Volume(issue)/page/year: 1,30,1981
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 420 ppm/4H
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - excitement
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
8,101,1987
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 171 mg/kg
TOXIC EFFECTS :
Liver - other changes
Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
RCSADO Research Communications in Substances Abuse. (PJD Pub. Ltd., P.O.Box
966, Westbury, NY 11590) V.1- 1980- Volume(issue)/page/year: 3,233,1982
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 567 ppm/1H
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - cyanosis
Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
1,448,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 158 mg/kg
TOXIC EFFECTS :
Liver - other changes
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
Volume(issue)/page/year: 26,75,1979
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 300 ppm/7H/60D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight
Endocrine - changes in spleen weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
etc.)
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
Volume(issue)/page/year: 5,134,1985
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 1 mg/plate
REFERENCE :
BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale. (Casa
Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy) V.2- 1927-
Volume(issue)/page/year: 56,816,1980
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 2820 umol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
14,115,1989
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 1 mg/m3 JAN 1993
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
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Nitrosporin
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Nitrous acid
| 7782-77-6 |
Nitrous acid, butyl ester
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Nitrous acid, sec-butyl ester
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Nitrous acid, t-butyl ester
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Nitrous acid, isobutyl ester
| 542-56-3 |
Nitrous acid, ethyl ester
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Nitrous acid, isopropyl ester
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Nicotinamide, N-(3-(3-indolyl)propyl)-, hydrochloride
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Nitrous acid, methyl ester
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Nitrous acid, nickel (2+) salt
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Nitrous acid, pentyl ester
| 463-04-7 |
Nitrous acid, propyl ester
| 543-67-9 |
Nitrous acid, sodium salt
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Nitroxide, di-tert-butyl
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NK 154183A
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NK 154183B
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NN-105
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Noboritomycin A
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Nicotinamide, N-isopentyl-2-(p-methylanilino)-
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Noboritomycin A, 4-demethyl-4-ethyl-
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Nocardicin complex
| 76631-42-0 |
Nocardin
| 101975-69-3 |
Nocardorubin
| 1404-14-4 |
NOF-005SUBSTANCE DEFINITION :Chief ingredient of tricaprylinREFERENCE :KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, KandaSuda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-Volume(issue)/page/year: 28,7,1994
| 1404-14-4 |
Nogalamycin
| 1404-15-5 |
Nomate blockaide
| 85800-68-6 |
Nonactin,5,14,23,32-tetrademethyl-5,14,23,32-tetraethyl-
| 33956-61-5 |
2,3-Nonadecanediamine, dihydrochloride, (+-)-
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1,2,3-Nonadecanetricarboxylic acid, 2-hydroxy-
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Nicotinamide, 2-(p-methoxyanilino)-N-methyl-
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1,2,3-Nonadecanetricarboxylic acid, 2-hydroxy-,sodium salt
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10-Nonadecanone, 1,19-difluoro-
| 462-17-9 |
2,10,12,16,18-Nonadecapentanoic acid,19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl- 6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-
| 87081-35-4 |
2,10,12,16,18-Nonadecapentaenoic acid,19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo-
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5,9,13,17-Nonadecatetraen-2-one,6,10,14,18-tetramethyl-
| 6809-52-5 |
10-Nonadecenamide,N-((4-hydroxy-3-methoxyphenyl)methyl)-, (Z)-
| 95548-11-1 |
2,6-Nonadienal, (E,Z)-
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2,6-Nonadien-1-al, 3,7-dimethyl-
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2,6-Nonadienenitrile, 3,7-dimethyl-
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2,6-Nonadienol
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Nicotinamide, 2-(p-methoxyanilino)-N-propyl-
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1,6-Nonadien-3-ol, 3,7-dimethyl-
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5,7-Nonadiyn-4-one, 9-(2-naphthalenyloxy)-
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