*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : RO0375000
CHEMICAL NAME : 1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-phenethyl-,
monohydrochloride
CAS REGISTRY NUMBER : 5053-08-7
LAST UPDATED : 199012
DATA ITEMS CITED : 8
MOLECULAR FORMULA : C15-H20-N2-O2.Cl-H
MOLECULAR WEIGHT : 296.83
WISWESSER LINE NOTATION : T6N CXTJ A2R& C-& DT5MVOX EHJ &GH
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Chlorhydrate de phenethyl-8-oxa-1-diaza-3,8-spiro(4,5)decanone-2
* Decaspir
* Decaspiride hydrochloride
* Espiran
* 8-N-Fenetil-1-oxa-2-oxo-3,8-diazaspiro-(4,5)-decano cloridrato
* Fenspiride
* Fenspiride hydrochloride
* Fluiden
* JP 428 hydrochloride
* NAT-333 hydrochloride
* NDR-5998A hydrochloride
* 8-(2-Phenylethyl)-1-oxa-3,8-diazaspiro(4.5)decan-2-one hydrochloride
* Phenethyl-8-oxa-1-diaza-3,8-spiro(4,5)decanone-2-hydrochloride
* Pneumorel
* Respiride
* Tegencia hydrochloride
* Viarespan hydrochloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 437 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 19,1263,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 122 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 193,111,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 250 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 193,111,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 230 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 19,1263,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 106 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 19,1263,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 74 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Behavioral - aggression
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica,
Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year:
117,343,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 260 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 193,111,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 210 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 193,111,1971
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,3-ethyl-4-methylene-8-(2-phenylethyl)-
| 134069-67-3 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(3-(p-fluorobenzoyl)propyl)-3,4-dimethyl-,hydrochloride
| 102504-25-6 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(p-fluorophenethyl)-
| 5500-76-5 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(4-fluorophenyl)ethyl)-4-hydroxy-3,4-dimethyl-
| 134070-06-7 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(4-fluorophenyl)ethyl)-4-hydroxy-4-methyl-3-(phenylmethyl)-, monohydrochloride
| 134070-05-6 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(4-fluorophenyl)ethyl)-4-hydroxy-4-methyl-3-(1-methylethyl)-
| 134070-11-4 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(4-fluorophenyl)ethyl)-4-hydroxy-4-methyl-3-propyl-, monohydrochloride
| 134070-14-7 |
4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid,3-(2-hydroxyethylidene)-7-oxo-,(2R-(2-alpha,3Z,5-alpha))-
| 58001-44-8 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(4-fluorophenyl)ethyl)-4-hydroxy-4-methyl-3-(1-naphthalenyl)-, monohydrochloride
| 134070-18-1 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(4-fluorophenyl)ethyl)-4-hydroxy-4-methyl-3-phenyl-, monohydrochloride
| 134070-23-8 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(4-fluorophenyl)ethyl)-4-methylene-3-(phenylmethyl)-
| 134069-53-7 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(4-fluorophenyl)ethyl)-4-methylene-3-(1-methylethyl)-
| 134069-74-2 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(4-fluorophenyl)ethyl)-4-methylene-3-(1-naphthalenyl)-
| 134069-88-8 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(4-fluorophenyl)ethyl)-4-methylene-3-phenyl-
| 134069-66-2 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(4-fluorophenyl)ethyl)-4-methylene-3-propyl-
| 134069-76-4 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(4-fluorophenyl)ethyl)-3-methyl-4-methylene-
| 134069-72-0 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(3-(2-furyl)propyl)-, hydrochloride
| 23805-00-7 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,4-hydroxy-3,4-dimethyl-8-(2-phenylethyl)-
| 134070-04-5 |
4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid,3-(2-hydroxyethylidene)-7-oxo-, (2R-(2-alpha,3Z,5-alpha))-, mixt. with(2S-(2-alpha,5-alpha,6-beta(S*)))-6-((carboxy-3-thienylacetyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane- 2-carboxylic acid
| 86482-18-0 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(4-hydroxy-3-(methoxycarbonyl))benzyl-, succinate
| 74195-67-8 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-hydroxy-3-phenyl)propyl-
| 5229-85-6 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(beta-methoxyphenethyl)-, hydrochloride
| 23804-90-2 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(p-methoxyphenethyl)-, hydrochloride
| 23804-74-2 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(o-methoxyphenoxy)ethyl)-, hydrochloride
| 23804-93-5 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(3,4-(methylenedioxy)phenethyl)-
| 5229-89-0 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,4-methylene-8-(2-phenylethyl)-3-propyl-
| 134069-98-0 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,4-methylene-3-phenyl-8-(2-phenylethyl)-
| 134069-60-6 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,3-methyl-4-methylene-8-(2-phenylethyl)-
| 134069-62-8 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-((alpha-methyl)phenethyl)-
| 5053-09-8 |
4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid,3-(2-hydroxyethylidene)-7-oxo-, monopotassium salt,(2R-(2-alpha,3Z,5-alpha))-
| 61177-45-5 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(p-methylphenethyl)-, hydrochloride
| 23804-73-1 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-(phenacyl)-,hydrochloride
| 23804-95-7 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-phenethyl-
| 5053-06-5 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-phenethyl-,monohydrochloride
| 5053-08-7 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-phenoxyethyl)-, hydrochloride
| 5052-99-3 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(3-phenylpropenyl)-
| 23804-85-5 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(3-phenyl)propyl-, hydrochloride
| 6110-67-4 |
1-Oxa-3,8-diazaspiro(4.5)decan-9-one,8-(p-propionamido)phenethyl-, hydrochloride
| 69382-12-3 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(2-pyridyl)ethyl)-
| 23804-98-0 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(4-pyridyl)ethyl)-, dihydrochloride
| 23804-99-1 |
Osbeckia aspera (L.) Bl. var. travancorica (bedd. exGamble) Hanson, extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family MelastomataceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,487,1984
| 23804-99-1 |
4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid,3-(2-hydroxyethylidene)-7-oxo-, monopotassium salt,(2R-(2-alpha,3Z,5-alpha))-, mixt. with(2S-(2-alpha,5-alpha,6-beta(S*)))-6-((amino(4-hydroxyphenyl)acetyl)amino)-3,3-dimethyl-7-oxo-4- thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid (1:2)
| 74469-00-4 |
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(m-(trifluoromethyl)phenethyl)-, hydrochloride
| 23804-75-3 |
9-Oxa-2,4-diazaspiro(5.5)undecane-1,3,5-trione,8,10-bis(bromomethyl)-
| 99359-52-1 |
9-Oxa-2,4-diazaspiro(5.5)undecane-1,3,5-trione,8,10-bis(iodomethyl)-
| 56865-28-2 |
9-Oxa-2,4-diazaspiro(5.5)undecane-1,3,5-trione,8-(bromomethyl)-10-methyl-
| 56865-27-1 |
9-Oxa-2,4-diazaspiro(5.5)undecane-1,3,5-trione,8-(iodomethyl)-10-methyl-
| 99074-75-6 |
1-Oxa-3,9-diazaspiro(5.5)undecan-2-one,9-(3-(p-chlorobenzoyl)propyl)-
| 54981-19-0 |
1-Oxa-3,9-diazaspiro(5.5)undecan-2-one,9-(3-(p-chlorobenzoyl)propyl)-5-methyl-
| 54981-20-3 |
1-Oxa-3,9-diazaspiro(5.5)undecan-2-one,5-ethyl-9-(3-(p-chlorobenzoyl)propyl)-
| 54981-21-4 |
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