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MSDS  : 4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, (2R-(2- alpha,3Z,5-alpha))-, mixt. with (2S-(2-alpha,5-alpha,6-beta(S*)))-6-((carboxy-3- thienylacetyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azab icyclo(3.2.0)heptane- 2-carboxylic acid
CAS  : 86482-18-0
SYNONYMS  : * BRL 28500 * Clavulanic acid - ticarcillin mixt. * Ticarcillin - clavulanic acid mixt. * Timentin
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : RN6802600
CHEMICAL NAME : 4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid,
3-(2-hydroxyethylidene)-7-oxo-, (2R-(2-
alpha,3Z,5-alpha))-, mixt. with
(2S-(2-alpha,5-alpha,6-beta(S*)))-6-((carboxy-3-
thienylacetyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azab
icyclo(3.2.0)heptane- 2-carboxylic acid
CAS REGISTRY NUMBER : 86482-18-0
LAST UPDATED : 199506
DATA ITEMS CITED : 9
MOLECULAR FORMULA : C15-H16-N2-O6-S2.C8-H9-N-O5
MOLECULAR WEIGHT : 583.63
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* BRL 28500
* Clavulanic acid - ticarcillin mixt.
* Ticarcillin - clavulanic acid mixt.
* Timentin

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 12990 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
34(Suppl 4),69,1986

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 7295 mg/kg
TOXIC EFFECTS :
Skin and Appendages - hair
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
34(Suppl 4),69,1986

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4968 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
34(Suppl 4),69,1986

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
34(Suppl 4),69,1986

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 12635 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
34(Suppl 4),69,1986

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 7118 mg/kg
TOXIC EFFECTS :
Skin and Appendages - hair
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
34(Suppl 4),69,1986

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 3792 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
34(Suppl 4),69,1986

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
34(Suppl 4),69,1986

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 56 gm/kg/5W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - normocytic anemia
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
34(Suppl 4),96,1986

*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,3-ethyl-4-methylene-8-(2-phenylethyl)- 134069-67-3
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(3-(p-fluorobenzoyl)propyl)-3,4-dimethyl-,hydrochloride 102504-25-6
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(p-fluorophenethyl)- 5500-76-5
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(4-fluorophenyl)ethyl)-4-hydroxy-3,4-dimethyl- 134070-06-7
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(4-fluorophenyl)ethyl)-4-hydroxy-4-methyl-3-(phenylmethyl)-, monohydrochloride 134070-05-6
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(4-fluorophenyl)ethyl)-4-hydroxy-4-methyl-3-(1-methylethyl)- 134070-11-4
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(4-fluorophenyl)ethyl)-4-hydroxy-4-methyl-3-propyl-, monohydrochloride 134070-14-7
4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid,3-(2-hydroxyethylidene)-7-oxo-,(2R-(2-alpha,3Z,5-alpha))- 58001-44-8
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(4-fluorophenyl)ethyl)-4-hydroxy-4-methyl-3-(1-naphthalenyl)-, monohydrochloride 134070-18-1
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(4-fluorophenyl)ethyl)-4-hydroxy-4-methyl-3-phenyl-, monohydrochloride 134070-23-8
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(4-fluorophenyl)ethyl)-4-methylene-3-(phenylmethyl)- 134069-53-7
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(4-fluorophenyl)ethyl)-4-methylene-3-(1-methylethyl)- 134069-74-2
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(4-fluorophenyl)ethyl)-4-methylene-3-(1-naphthalenyl)- 134069-88-8
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(4-fluorophenyl)ethyl)-4-methylene-3-phenyl- 134069-66-2
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(4-fluorophenyl)ethyl)-4-methylene-3-propyl- 134069-76-4
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(4-fluorophenyl)ethyl)-3-methyl-4-methylene- 134069-72-0
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(3-(2-furyl)propyl)-, hydrochloride 23805-00-7
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,4-hydroxy-3,4-dimethyl-8-(2-phenylethyl)- 134070-04-5
4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid,3-(2-hydroxyethylidene)-7-oxo-, (2R-(2-alpha,3Z,5-alpha))-, mixt. with(2S-(2-alpha,5-alpha,6-beta(S*)))-6-((carboxy-3-thienylacetyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane- 2-carboxylic acid 86482-18-0
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(4-hydroxy-3-(methoxycarbonyl))benzyl-, succinate 74195-67-8
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-hydroxy-3-phenyl)propyl- 5229-85-6
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(beta-methoxyphenethyl)-, hydrochloride 23804-90-2
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(p-methoxyphenethyl)-, hydrochloride 23804-74-2
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(o-methoxyphenoxy)ethyl)-, hydrochloride 23804-93-5
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(3,4-(methylenedioxy)phenethyl)- 5229-89-0
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,4-methylene-8-(2-phenylethyl)-3-propyl- 134069-98-0
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,4-methylene-3-phenyl-8-(2-phenylethyl)- 134069-60-6
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,3-methyl-4-methylene-8-(2-phenylethyl)- 134069-62-8
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-((alpha-methyl)phenethyl)- 5053-09-8
4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid,3-(2-hydroxyethylidene)-7-oxo-, monopotassium salt,(2R-(2-alpha,3Z,5-alpha))- 61177-45-5
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(p-methylphenethyl)-, hydrochloride 23804-73-1
1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-(phenacyl)-,hydrochloride 23804-95-7
1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-phenethyl- 5053-06-5
1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-phenethyl-,monohydrochloride 5053-08-7
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-phenoxyethyl)-, hydrochloride 5052-99-3
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(3-phenylpropenyl)- 23804-85-5
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(3-phenyl)propyl-, hydrochloride 6110-67-4
1-Oxa-3,8-diazaspiro(4.5)decan-9-one,8-(p-propionamido)phenethyl-, hydrochloride 69382-12-3
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(2-pyridyl)ethyl)- 23804-98-0
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(2-(4-pyridyl)ethyl)-, dihydrochloride 23804-99-1
Osbeckia aspera (L.) Bl. var. travancorica (bedd. exGamble) Hanson, extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family MelastomataceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,487,1984 23804-99-1
4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid,3-(2-hydroxyethylidene)-7-oxo-, monopotassium salt,(2R-(2-alpha,3Z,5-alpha))-, mixt. with(2S-(2-alpha,5-alpha,6-beta(S*)))-6-((amino(4-hydroxyphenyl)acetyl)amino)-3,3-dimethyl-7-oxo-4- thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid (1:2) 74469-00-4
1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(m-(trifluoromethyl)phenethyl)-, hydrochloride 23804-75-3
9-Oxa-2,4-diazaspiro(5.5)undecane-1,3,5-trione,8,10-bis(bromomethyl)- 99359-52-1
9-Oxa-2,4-diazaspiro(5.5)undecane-1,3,5-trione,8,10-bis(iodomethyl)- 56865-28-2
9-Oxa-2,4-diazaspiro(5.5)undecane-1,3,5-trione,8-(bromomethyl)-10-methyl- 56865-27-1
9-Oxa-2,4-diazaspiro(5.5)undecane-1,3,5-trione,8-(iodomethyl)-10-methyl- 99074-75-6
1-Oxa-3,9-diazaspiro(5.5)undecan-2-one,9-(3-(p-chlorobenzoyl)propyl)- 54981-19-0
1-Oxa-3,9-diazaspiro(5.5)undecan-2-one,9-(3-(p-chlorobenzoyl)propyl)-5-methyl- 54981-20-3
1-Oxa-3,9-diazaspiro(5.5)undecan-2-one,5-ethyl-9-(3-(p-chlorobenzoyl)propyl)- 54981-21-4

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