*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : SH1225000
CHEMICAL NAME : Phenethylamine, p-chloro-alpha,alpha-dimethyl-,
hydrochloride
CAS REGISTRY NUMBER : 151-06-4
LAST UPDATED : 199503
DATA ITEMS CITED : 11
MOLECULAR FORMULA : C10-H14-Cl-N.Cl-H
MOLECULAR WEIGHT : 220.16
WISWESSER LINE NOTATION : ZX1&1&1R DG &GH
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Avicol
* Benzeneethanamine, 4-chloro-alpha,alpha-dimethyl-, hydrochloride
* p-Chloro-alpha,alpha-dimethylphenethylamine hydrochloride
* 4-Chloro-alpha,alpha-dimethylphenethylamine hydrochloride
* Chlorophentermine hydrochloride
* 1-(p-Chlorophenyl)-2-methyl-2-aminopropane hydrochloride
* Chlorphentermine hydrochloride
* alpha,alpha-Dimethyl-p-chlorophenethylamine hydrochloride
* Lucofen
* Lucofene
* NSC-76098
* Pre-Sate
* Presate hydrochloride
* S-62
* S 62-2
* W 2426
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 150 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
REFERENCE :
CHTPBA Chimica Therapeutica. (Paris, France) V.1-8, 1965-73. For
publisher information, see EJMCA5. Volume(issue)/page/year: 5,247,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 144 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
17,121,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 225 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 13,711,1963
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 88 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
REFERENCE :
CHTPBA Chimica Therapeutica. (Paris, France) V.1-8, 1965-73. For
publisher information, see EJMCA5. Volume(issue)/page/year: 5,247,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 225 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - excitement
Skin and Appendages - hair
REFERENCE :
APSXAS Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska
Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964-
Volume(issue)/page/year: 4,37,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 55 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - changes in motor activity (specific assay)
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 137,365,1962
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 840 mg/kg/2W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
65,100,1982
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 27 mg/kg
SEX/DURATION : female 12-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth)
Reproductive - Effects on Newborn - physical
REFERENCE :
VAAZA2 Virchows Archiv, Abteilung B: Cell Pathology. (Springer-Verlag,
Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1968-
Volume(issue)/page/year: 39,59,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 150 mg/kg
SEX/DURATION : female 16-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 1,31,1981
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 150 mg/kg
SEX/DURATION : female 16-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
EXMPA6 Experimental and Molecular Pathology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1962- Volume(issue)/page/year:
38,310,1983
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE : 21 mg/kg
SEX/DURATION : female 32-68 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - physical
REFERENCE :
VAAZA2 Virchows Archiv, Abteilung B: Cell Pathology. (Springer-Verlag,
Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1968-
Volume(issue)/page/year: 39,59,1982
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Phenethylamine,N-butyl-alpha,N-dimethyl-m-trifluoromethyl-
| 74051-03-9 |
Phenethylamine, N-butyl-o-methoxy-alpha-methyl-,hydrochloride
| 100966-44-7 |
Phenethylamine, N-butyl-alpha-methyl-
| 51799-33-8 |
Phenanthro(2,3-h)isoquinoline
| 24903-46-6 |
Phenethylamine,N-butyl-alpha-methyl-m-trifluoromethyl-
| 52742-18-4 |
Phenethylamine, alpha-butyl-3,4,5-trimethoxy-
| 15886-81-4 |
Phenethylamine, N,N'-(2-butynylene)bis(N-benzyl-,dihydrochloride
| 15886-81-4 |
Phenethylamine, N,N'-(2-butynylene)bis(N-ethyl-,dihydrochloride
| 15886-81-4 |
Phenethylamine, N,N'-(2-butynylene)bis(N-methyl-,dihydrochloride
| 15886-81-4 |
Phenethylamine, N-(o-chlorobenzyl)-N,alpha-dimethyl-,hydrochloride, (+)-
| 13364-34-6 |
Phenethylamine, N-(p-chlorobenzyl)-N,alpha-dimethyl-,hydrochloride, (+)-
| 5863-31-0 |
Phenethylamine, N-(o-chlorobenzyl)-alpha-methyl-,hydrochloride, (+)-
| 5843-53-8 |
Phenethylamine, N-(p-chlorobenzyl)-alpha-methyl-,hydrochloride, (+)-
| 13371-56-7 |
Phenethylamine,N-p-chlorobenzyl-alpha-methyl-beta-phenyl-,monohydrochloride
| 51729-70-5 |
Phenanthro(3,2-h)isoquinoline
| 24903-48-8 |
Phenethylamine,beta-chloro-N-(2-chloroethyl)-alpha,N-dimethyl-,hydrochloride
| 23173-38-8 |
Phenethylamine, 3-chloro-alpha-(p-chlorophenyl)-,hydrochloride
| 68968-07-0 |
Phenethylamine, 4-chloro-alpha-(p-chlorophenyl)-,hydrochloride, hemihydrate
| 68968-03-6 |
Phenethylamine,5-chloro-beta-cyclohexyl-N,N-dimethyl-2-ethoxy-
| 35366-24-6 |
Phenethylamine,5-chloro-beta-cyclopentyl-N,N-dimethyl-2-ethoxy-
| 35366-22-4 |
Phenethylamine, beta-chloro-N,N-dibenzyl-
| 35366-22-4 |
Phenethylamine,3-chloro-alpha-(3,4-dimethoxyphenyl)-, hydrochloride
| 68968-15-0 |
Phenethylamine, o-chloro-N,alpha-dimethyl-
| 4302-93-6 |
Phenethylamine, p-chloro-N,alpha-dimethyl-
| 1199-85-5 |
Phenethylamine, p-chloro-alpha,alpha-dimethyl-
| 461-78-9 |
Phenanthridinium, 5-(3-(trimethylammonio)propyl)-,dibromide
| 4935-85-7 |
Phenanthro(9,10-g)isoquinoline
| 110520-17-7 |
Phenethylamine, 3-chloro-alpha,beta-dimethyl-
| 20110-25-2 |
Phenethylamine,2-chloro-4-dimethylamino-alpha-ethyl-,dihydrochloride
| 55875-64-4 |
Phenethylamine,2-chloro-4-dimethylamino-alpha-methyl-,dihydrochloride
| 55875-53-1 |
Phenethylamine,2-chloro-alpha,alpha-dimethyl-4-dimethylamino-,dihydrochloride, hydrate
| 74051-04-0 |
Phenethylamine,5-chloro-N,N-dimethyl-2-ethoxy-beta-propyl-
| 35366-20-2 |
Phenethylamine, beta-chloro-N,alpha-dimethyl-,hydrochloride, DL-
| 35366-20-2 |
Phenethylamine, beta-chloro-N,N-dimethyl-,hydrochloride
| 32184-20-6 |
Phenethylamine, m-chloro-alpha,alpha-dimethyl-,hydrochloride
| 64057-68-7 |
Phenethylamine, o-chloro-alpha,alpha-dimethyl-,hydrochloride
| 10389-72-7 |
Phenethylamine, p-chloro-alpha,alpha-dimethyl-,hydrochloride
| 151-06-4 |
9-Phenanthrol
| 484-17-3 |
Phenethylamine, 3-chloro-alpha,beta-dimethyl-,hydrochloride
| 20110-53-6 |
Phenethylamine, p-chloro-N,N-dimethyl-beta-methoxy-
| 67428-87-9 |
Phenethylamine, beta-chloro-N,N-dimethyl-p-methoxy-,hydrochloride
| 13432-66-1 |
Phenethylamine,p-chloro-alpha,beta-dimethyl-N-propyl-
| 20110-30-9 |
Phenethylamine,4-chloro-alpha,beta-dimethyl-N-propyl-, hydrochloride
| 20110-58-1 |
Phenethylamine,4-chloro-alpha,alpha-dimethyl-N-veratryl-
| 68398-00-5 |
Phenethylamine,N-(beta-chloroethyl)-N,alpha-dimethyl-, hydrochloride
| 35059-09-7 |
Phenethylamine, N-(2-chloroethyl)-N-ethyl-,hydrochloride
| 15512-85-3 |
Phenethylamine,N-(2-chloroethyl)-alpha-methyl-m-trifluoromethyl-
| 74051-05-1 |
Phenethylamine, p-chloro-N-methoxy-alpha-methyl-,hydrochloride, (+-)-
| 90945-04-3 |
1,10-Phenanthroline
| 66-71-7 |
Phenethylamine, 3-chloro-alpha-(p-methoxyphenyl)-,hydrochloride
| 68968-08-1 |
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