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MSDS  : 1,10-Phenanthroline
CAS  : 66-71-7
SYNONYMS  : * 4,5-Diazaphenanthrene * 1,10-Fenanthrolin * Orthophenanthroline * beta-Phenanthroline * o-Phenanthroline * 1,10-o-Phenanthroline
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : SF8300000
CHEMICAL NAME : 1,10-Phenanthroline
CAS REGISTRY NUMBER : 66-71-7
LAST UPDATED : 199701
DATA ITEMS CITED : 7
MOLECULAR FORMULA : C12-H8-N2
MOLECULAR WEIGHT : 180.22
WISWESSER LINE NOTATION : T B666 CN NNJ
COMPOUND DESCRIPTOR : Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* 4,5-Diazaphenanthrene
* 1,10-Fenanthrolin
* Orthophenanthroline
* beta-Phenanthroline
* o-Phenanthroline
* 1,10-o-Phenanthroline

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 75 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Kidney, Ureter, Bladder - other changes
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 196,478,1976

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 137,1,1962

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 30 mg/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 66,1755,1977

** MUTATION DATA **

TYPE OF TEST : DNA inhibition
TEST SYSTEM : Human Leukocyte
DOSE/DURATION : 5 mg/L
REFERENCE :
ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21-
1967- Volume(issue)/page/year: 46,193,1989

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 82276
No. of Facilities: 1002 (estimated)
No. of Industries: 12
No. of Occupations: 11
No. of Employees: 8324 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 82276
No. of Facilities: 2265 (estimated)
No. of Industries: 33
No. of Occupations: 35
No. of Employees: 40330 (estimated)
No. of Female Employees: 2577 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY


*** END OF RECORD ***
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