*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : SZ1300000
CHEMICAL NAME : Phosphine oxide,
1,4-piperazinediylbis(bis(1-aziridinyl)-
CAS REGISTRY NUMBER : 738-99-8
BEILSTEIN REFERENCE NO. : 0629375
REFERENCE : 5-23-03-00231 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 14
MOLECULAR FORMULA : C12-H24-N6-O2-P2
MOLECULAR WEIGHT : 346.36
WISWESSER LINE NOTATION : T6N DNTJ APO&- AT3NTJ&- AT3NTJ& DPO&- AT3NTJ&- AT3NTJ
COMPOUND DESCRIPTOR : Mutagen
SYNONYMS/TRADE NAMES :
* 1,4-Bis(N,N'-diethylene phosphamide)piperazine
* Dipin
* Dipine
* ENT-50107
* Piperazine, 1,4-bis(bis(1-aziridinyl)phosphinyl)-
* 1,4-Piperazinediylbis(bis(1-aziridinyl)phosphine oxide)
* Tetra-ethyleneimidepiperazine-N,N'-diphosphoric acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 68 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPTOAN Russian Pharmacology and Toxicology (English Translation).
Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
UK) V.30- 1967- Volume(issue)/page/year: 36,240,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 90 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1-
1967- Volume(issue)/page/year: 14,363,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 58 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher
information, see AMBIEH. Volume(issue)/page/year: 21,262,1976
** MUTATION DATA **
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 24 mmol/L
REFERENCE :
CNJGA8 Canadian Journal of Genetics and Cytology. (National Research
Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,
Canada) V.1- 1959- Volume(issue)/page/year: 11,648,1969
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Unreported
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 1 pph/3H (Continuous)
REFERENCE :
AESAAI Annals of the Entomological Society of America. (Entomological Soc.
of America, 4603 Calvert Rd., College Park, MD 20740) V.1- 1908-
Volume(issue)/page/year: 62,790,1969
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 24 mmol/L
REFERENCE :
CNJGA8 Canadian Journal of Genetics and Cytology. (National Research
Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,
Canada) V.1- 1959- Volume(issue)/page/year: 11,648,1969
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 29 umol/L
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp.,
233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year:
10,1580,1974
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 10 mg/L
REFERENCE :
TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English
translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1- 1967- Volume(issue)/page/year: 16(2),34,1982
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 60 mg/kg
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp.,
233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year:
11,1347,1975
TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 60 mg/kg
REFERENCE :
IANBAM Izvestiya Akademii Nauk SSSR, Seriya Biologicheskaya. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1936-
Volume(issue)/page/year: (6),816,1991
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 10 mg/kg
REFERENCE :
CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK.
(Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974-
Volume(issue)/page/year: 19(1),23,1985
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 2 mg/kg
REFERENCE :
CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK.
(Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974-
Volume(issue)/page/year: 19(1),23,1985
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Cells - not otherwise specified
DOSE/DURATION : 5700 nmol/L
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp.,
233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year:
18,210,1982
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Mammal - pig
DOSE/DURATION : 20 mg/kg
REFERENCE :
CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK.
(Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974-
Volume(issue)/page/year: 10(6),54,1976
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Phosphonic acid,(3-(4-(dimethylamino)phenyl)-4,5-dihydro-5-isoxazolyl)-, monohydrobromide
| 125674-86-4 |
Phosphonic acid, dimethyl ester
| 868-85-9 |
Phosphonic acid,(3-(1,1-dimethylethyl)-4,5-dihydro-5-isoxazolyl)-
| 125674-52-4 |
Phosphonic acid,(4-(diphenylhydroxymethyl)piperidino)-, dibutyl ester
| 125674-52-4 |
Phosphonic acid, (dithiodimethylene)di-, tetramethylester
| 32674-23-0 |
Phosphonic acid,(4-(di-o-tolylhydroxymethyl)piperidino)-, diethylester
| 32674-23-0 |
Phosphonic acid, dodecyl-
| 5137-70-2 |
Phosphonic acid, (1,2-epoxypropyl)-, (1R,2S)-(-)-
| 23155-02-4 |
Phosphonic acid, (1,2-epoxypropyl)-, calcium salt(1:1), (1R,2S)-(-)-
| 26016-98-8 |
Phosphonic acid, 2,3-epoxypropyl-, diethyl ester
| 7316-37-2 |
Phosphine oxide, hexyldipentyl-
| 74038-20-3 |
Phosphonic acid, (1,2-epoxypropyl)-, disodium salt(1R,2S) (-)-
| 26016-99-9 |
Phosphonic acid, 1,2-ethanediylbis-
| 6145-31-9 |
Phosphonic acid, ethenyl-
| 1746-03-8 |
Phosphonic acid, ethenyl-,bis(2-((butoxymethylphosphinyl)oxy)ethyl) ester
| 53529-45-6 |
Phosphonic acid, (2-ethoxyethyl)-, diethyl ester
| 5191-35-5 |
Phosphonic acid, (m-ethylaminophenyl)-
| 100860-49-9 |
Phosphonic acid, ethyl-, bis(p-chlorophenyl) ester
| 100860-49-9 |
Phosphonic acid, ethyl-, butyl p-nitrophenyl ester
| 71002-67-0 |
Phosphonic acid, ethyl-, p-chlorophenyl methyl ester
| 33232-87-0 |
Phosphonic acid, ethyl-, cyclic methylene-o-phenyleneester
| 5853-68-9 |
Phosphine oxide,1,4-piperazinediylbis(bis(1-aziridinyl)-
| 738-99-8 |
Phosphonic acid, ethyl-, ethyl ester, ester withp-hydroxybenzamide
| 74038-41-8 |
Phosphonic acid, ethyl, O-ethylO-(2-(ethylthio)-6-methyl-4-pyrimidinyl) ester
| 25537-46-6 |
Phosphonic acid, ethyl-, ethyl methyl ester
| 5301-65-5 |
Phosphonic acid, ethyl-, ethyl p-nitrophenyl ester
| 546-71-4 |
Phosphonic acid, (2-ethyl-1-hydroxyhexyl)-
| 7506-91-4 |
Phosphonic acid, ethyl-, isopropyl p-nitrophenylester
| 7284-58-4 |
Phosphonic acid, ethyl-, methyl (p-cyanophenyl) ester
| 33232-88-1 |
Phosphonic acid, ethyl-, methylp-(methylsulfonyl)phenyl ester
| 33267-37-7 |
Phosphonic acid, ethyl-, methyl p-nitrophenyl ester
| 15536-01-3 |
Phosphonic acid, ethyl-, methyl p-tolyl ester
| 33232-85-8 |
Phosphine oxide,1,4-piperazinediylbis(bis(1-aziridinyl)-, plusN-(5-(aminosulfonyl)-1,3,4- thiadiazol-2-yl)acetamide
| 72060-03-8 |
Phosphonic acid, ethyl-, monoethyl ester
| 7305-61-5 |
Phosphonic acid, ethylthiomethyl-, dibutyl ester
| 74038-42-9 |
Phosphonic acid, ((ethylthio)methylidyne)tri-,hexaethyl ester
| 3247-33-4 |
Phosphonic acid,((ethylthio)(phenylthio)methylene)bis-, tetraethylester
| 63869-22-7 |
Phosphonic acid,(5-(3-fluorobenzoyl)-2,4-dihydro-3H-pyrazol-3-ylidene)bis-, tetraethyl ester
| 132508-17-9 |
Phosphonic acid, fluoro-, ethyl isopropyl ester
| 132508-17-9 |
Phosphonic acid, p-fluorophenyl-,bis(2-(dimethylamino)ethyl) ester
| 339-32-2 |
Phosphonic acid,(3-(4-fluorophenyl)-4,5-dihydro-5-isoxazolyl)-,dimethyl ester
| 125674-80-8 |
Phosphonic acid,(3-(formylhydroxyamino)-1-propenyl)-, (E)-
| 66508-88-1 |
Phosphonic acid,(3-(formylhydroxyamino)-1-propenyl)-, monopotassiumsalt, (E)-
| 66508-52-9 |
Phosphine oxide, tri(mixed(C4-C7)-alkyl)-
| 66508-52-9 |
Phosphonic acid, (3-(formylhydroxyamino)propyl)-,monosodium salt
| 66508-37-0 |
Phosphonic acid, heptyl-, O-ethyl O-(p-nitrophenyl)ester
| 3015-77-8 |
Phosphonic acid, (hexahydro-1H-azepin-1-yl)-, cyclicO,O,O',O'-neopentanetetrayl ester
| 19341-49-2 |
Phosphonic acid,(hexahydro-3,6-epoxyphthalimido)methyl-, diethylester
| 74038-43-0 |
Phosphonic acid, hexamethylenedi-, tetrabutyl ester
| 63904-89-2 |
Phosphonic acid,(1,6-hexanediylbis(nitrilobis(methylene)))tetrakis-
| 23605-74-5 |
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