LILLY ELI & PHARMACEUTICAL DIV -- VL7163 VINCRISTINE SULFATE INJECTION
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Material Safety Data Sheet
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MSDS Num: BXPPW
MSDS NAME: VL7163 VINCRISTINE SULFATE INJECTION
Responsible Party
Name: LILLY ELI & CO PHARMACEUTICAL DIV
Address: LILLY CORPORATE CENTER
City: INDIANAPOLIS IN 46285
Info Phone: 317-276-2000
Emergency Phone Number: 317-276-2000
Review Ind: Y
Published: Y
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Preparer Co. when other than Responsible Party Co.
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Assigned Ind: Y
Name: LILLY ELI & CO PHARMACEUTICAL DIV
Address: LILLY CORPORATE CENTER
City: INDIANAPOLIS IN 46285
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Contractor Summary
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Name: LILLY ELI & CO PHARMACEUTICAL DIV
Address: LILLY CORPORATE CENTER
City: INDIANAPOLIS IN 46285
Phone: 317-276-2000
Name: LILLY ELI AND CO PHARMACEUTICAL DIV
Address: LILLY CORPORATE CENTER
City: INDIANAPOLIS IN 46285
Phone: 317-276-2000
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Ingredients
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Cas: 2068-78-2
RTECS #: OH6340000
Name: VINCRISTINE SULFATE (IARC GROUP 3) * 95-1 *
% Wt: 9.1
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Cas: 64044-51-5
Name: LACTOSE
% Wt: 0-90
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Cas: 69-65-8
RTECS #: OP2060000
Name: MINNITOL, D- (MANNA SUGAR); MANNITOL
% Wt: 0-90
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Health Hazards Data
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Route Of Entry Inds - Inhalation: YES
Skin: YES
Ingestion: YES
Carcinogenicity Inds - NTP: NO
IARC: NO
OSHA: NO
Effects of Exposure: VINCRISTINE SULFATE- SKIN: IRRITANT. EYES: SEVERE
IRRITATION. PATIENTS TREATED W/COMBINATION THERAPY HAVE DEVELOPED SECOND
MALIGNANCIES/DECREASE IN FERTILITY. AT INTRAVENOUS DOSES SUPPRESSES BONE MARR
OW FUNCTION, WEAK IMMUNE SUPPRESSION HAS OCCURED IN A FEW PATIENTS. (SEE
SUPP)
Explanation Of Carcinogenicity: NONE
Signs And Symptions Of Overexposure: IRRITATION, DEPIGMENTATION, TEARING, PAIN,
BLURRED VISION, NAUSEA, VOMITING
Medical Cond Aggravated By Exposure: PATIENTS W/CHARCOT-MARIE-TOOTH SYNDROME,
WORKERS W/NEUROMUSCULAR DYSFUNCTION/SENSITIVITY TO VINCRISTINE SULFATE.
First Aid: EYES: FLUSH W/A STEADY, GENTLE STREAM OF WATER FOR 15 MINS. SKIN:
WASH W/PLENTY OF SOAP & WATER. INHALATION: MOVE TO FRESH AIR. IF NOT
BREATHING, GIVE CPR. INGESTION: DON'T INDUCE VOMITING. OBTAIN MED ICAL
ATTENTION IN ALL CASES. NOTE TO PHYSICIAN: A STEROID EYE OINTMENT/DROPS SERVE
TO MINIMIZE INFLAMMATION.
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Handling and Disposal
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Spill Release Procedures: USE EITHER WET CLEANUP METHODS/VACUUM CLEANERS W/HEPA
FILTERS. USE DOUBLE PAIRS OF LATEX DISPOSABLE GLOVES DISPOSING OF WITHIN AN
HOUR, GOGGLES & NIOSH APPROVED DUST-MIST RESPIRATOR.
Neutralizing Agent: MATERIAL MAY BE DECOMPOSED USING A BASIC (PH 10) SODIUM
HYPOCHLORIC SOLUTION.
Waste Disposal Methods: PLACE RESIDUE IN A SEGREGATED, SEALED PLASTIC
CONTAINER. VINCA ALKALOIDS ARE BIODEGRADEABLE. DISPOSE RESIDUE IAW/LOCAL,
STATE& FEDERAL REGULATIONS. IF DISPOSED BY INCINERATION, TEMP OF 850C FOR
SOLIDS & TEMP OF 950C FOR LIQUIDS ARE REQUIRED.
Handling And Storage Precautions: VINCRISTINE SULFATE IS A CYTOTOXIC MATERIAL.
Other Precautions: FOR WORK ENVIRONMENTS, EYE PROTECTION MUST BE PROVIDED &
HAND-TO-EYE CONTACT ELIMINATED. AVOID SKIN CONTACT.
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Fire and Explosion Hazard Information
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Unusual Fire/Explosion Hazard: MATERIAL MAY FORM DUST MIXTURES IN AIR &
EXPLODE IF SUBJECTED TO AN IGNITION SOURCE.
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Control Measures
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Respiratory Protection: USE A NIOSH APPROVED DUST-MIST RESPIRATOR/SAFETY
EQUIPMENT. IN PRODUCTION SETTINGS, AIRLINE-SUPPLIED, HOOD-TYPE RESPIRATORS
ARE PREFERRED TO PROVIDE FACE/EYE & RESPIRATORY PROTECTION.
Ventilation: EXTENSIVE LOCAL EXHAUST/ENCLOSED PROCESS EQUIPMENT
Protective Gloves: NATURAL RUBBER LATEX
Eye Protection: GOGGLES/FULL FACE MASK
Other Protective Equipment: IMPERVIOUS BODY COVERING; LONG SLEEVE
Work Hygienic Practices: REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE REUSE.
Supplemental Safety and Health: PH: 3.5-5.5 (RECONSTITUTED). HEALTH HAZ CONT'D:
INHALATION-LOCAL IRRITATION OF THE NOSE & THROAT. HOSPITAL EMPLOYEES
& HEALTH CARE PROVIDERS WHO PREPARE CYTOSTATIC DRUGS IN AN UNPROTECTED
ENVIRONMENT HAVE REPORTED HAVING INCREASED LEVELS OF MUTAGENS IN THEIR
URINE.
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Physical/Chemical Properties
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PH: (SUPP)
Solubility in Water: COMPLETE
Appearance and Odor: WHITE TO OFF-WHITE LYOPHILIZED PLUG W/NO ODOR
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Reactivity Data
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Stability Indicator: YES
Stability Condition To Avoid: IGNITION SOURCES
Hazardous Decomposition Products: TOXIC FUMES WHEN HEATED TO DECOMPOSITION
Hazardous Polymerization Indicator: NO
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Toxicological Information
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Ecological Information
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MSDS Transport Information
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Regulatory Information
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Other Information
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HAZCOM Label
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MSDS NAME: VL7163 VINCRISTINE SULFATE INJECTION
Assigned IND: Y
Company: LILLY ELI & CO PHARMACEUTICAL DIV
Street: LILLY CORPORATE CENTER
City: INDIANAPOLIS IN
Zipcode: 46285
Health Emergency Phone: 317-276-2000
Label Required IND: Y
Date Of Label Review: 12/16/1998
Status Code: C
Label Date: 12/16/1998
Origination Code: G
Hazard And Precautions: VINCRISTINE SULFATE- SKIN: IRRITANT. EYES: SEVERE
IRRITATION. PATIENTS TREATED W/COMBINATION THERAPY HAVE DEVELOPED SECOND
MALIGNANCIES/DECREASE IN FERTILITY. AT INTRAVENOUS DOSES SUPPRESSES BONE MARR
OW FUNCTION, WEAK IMMUNE SUPPRESSION HAS OCCURED IN A FEW PATIENTS. (SEE
SUPP) IRRITATION, DEPIGMENTATION,
TEARING, PAIN, BLURRED VISION, NAUSEA, VOMITING
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Disclaimer (provided with this information by the compiling agencies): This
information is formulated for use by elements of the Department of Defense.
The United States of America in no manner whatsoever expressly or implied
warrants, states, or intends said information to have any application, use or
viability by or to any person or persons outside the Department of Defense
nor any person or persons contracting with any instrumentality of the United
States of America and disclaims all liability for such use. Any person
utilizing this instruction who is not a military or civilian employee of the
United States of America should seek competent professional advice to verify
and assume responsibility for the suitability of this information to their
particular situation regardless of similarity to a corresponding Department
of Defense or other government situation.
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