===================== Product Identification =====================
MSDS NAME:53115 5-FLUOROURCIL
NIIN:01-022-2400
MSDS Number: BJPTV
=== Responsible Party ===
Company:HOFFMAN-LA ROCHE INC ROCHE LABORATORIES
Address:340 KINGSLAND ST
City:NUTLEY
State:NJ
ZIP:07110-1141
Country:US
Info Phone Num:800-526-6367
Emergency Phone Num:201-235-6660(CHEMTREC 800-424-9300)
Preparer's Name:HESHAM M. SOLIMAN
CAGE:04493
=== Contractor Identification ===
Company:HOFFMAN-LA ROCHE INC
Address:340 KINGSLAND ST
City:NUTLEY
State:NJ
ZIP:07110-1141
Country:US
Phone:201-235-2323
CAGE:04493
============= Composition/Information on Ingredients =============
Name:FLUOROURACIL (SARA 302) (MANUFACTURER STATES IN MSDS
>=98.5% BUT DLSC-TIR SAYS 5%)
CAS:51-21-8
RTECS #:YR0350000
Fraction by Wt: 5%
Other REC Limits:NONE RECOMMENDED
===================== Hazards Identification =====================
LD50 LC50 Mixture:ORAL LD50 (RAT) IS 100 MG/KG (SEE SUPP)
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:YES OSHA:NO
Health Hazards Acute and Chronic:ACUTE:MAY CAUSE CENTRAL NERVOUS SYSTEM
EFFECTS.INHALATION MAY CAUSE MUCOUS MEMBRANE IRRITATION.CONTACT MAY
CAUSE SKIN & EYE IRRITATION.INGESTION MAY CAUSE GI TRACT
IRRITATION;BLOOD SYSTEM CHANGES.CHRO NIC:PROLONGED/REPEATED
EXPOSURE MAY CAUSE LOSS OF COORDINATION,ALLERGIC SKIN
REACTIONS,DECREASE BONEMARROW CELL MAKING.
Explanation of Carcinogenicity:IARC LISTS AS UN CLASSIFIABLE (GRADE 3).
Effects of Overexposure:GENERAL (CNS): HEADACHE, DIZZINESS, DROWSINESS,
FATIGUE, LACK OF MUSCULAR COORDINATION. INHALED: SNEEZING,
COUGHING. INGESTED: NAUSEA, VOMITING, DIARRHEA, CONSTIPATION,
CRAMPS, LOSS OF APPETITE. SKIN: IRRITATION. EYES: IRRITATION.
Medical Cond Aggravated by Exposure:HYPERSENSITIVITY TO THIS MATERIALS,
BONE MARROW DEPRESSION, LIVER CONDITIONS, KIDNEY CONDITIONS,
PREGNANCY (MAY AFFECT FETAL DEVELOPMENT). NURSING MOMS-EXERCISE
CAUTION REGARDING POTENTIAL EXPOSURE.
======================= First Aid Measures =======================
First Aid:INHALED-REMOVE TO FRESH AIR. IF DISCOMFORT OCCURS OR
PERSISTS, GET MEDICAL ATTENTION. SKIN-REMOVE CONTAMINATED
CLOTHES/SHOES. WASH WITH SOAP & WATER. IF IRRITATION OCCURS OR
PERSISTS, GET MEDICAL ATTE NTION. EYES-FLUSH WITH LOTS OF WATER. IF
IRRITATION OCCURS OR PERSISTS, GET MEDICAL ATTENTION. INGESTED-GET
MEDICAL ATTENTION IMMEDIATELY. DO NOT INDUCE VOMITING UNLESS
DOIRECTED BY MEDICAL PERSONNEL.
===================== Fire Fighting Measures =====================
Extinguishing Media:WATER, CARBON DIOXIDE, DRY CHEMICAL, FOAM.
Fire Fighting Procedures:USE CAUTION IN APPROACHING FIRE. WEAR
SELF-CONTAINED BREATHING APPARATUS AND FULL PROTECTIVE GEAR. COOL
FIRE EXPOSED CONTAINERS WITH WATER.
Unusual Fire/Explosion Hazard:WEAK DUST EXPLOSION OR DUST FIRE HAZARD
(IF PURE POWDER). VIOLENT DECOMPOSITION CAN OCCUR WHEN HEATED OR IN
A FIRE.
================== Accidental Release Measures ==================
Spill Release Procedures:STOP LEAK IF FEASIBLE. WEAR PROPER PROTECTIVE
CLOTHING/EQUIPMENT. ELIMINATE ALL SOURCES OF IGNITION. SCOOP OR
SHOVEL SPILLED MATERIAL INTO A SUITABLE LABELED OPEN HEAD DRUM.
SECURE DRUM COVER AND MOVE TO SAFE HOLDING AREA. CLEAN SPILL
AREATHOROUGHLY
Neutralizing Agent:NONE SPECIFIED BY MANUFACTURER.
====================== Handling and Storage ======================
Handling and Storage Precautions:DO NOT HEAT ABOVE 200C. STORE IN A
COOL, DRY PLACE. KEEP CONTAINERS TIGHTLY CLOSED WHEN NOT IN USE.
USE WITH ADEQUATE VENTILATION.
Other Precautions:DO NOT GET IN EYES, ON SKIN OR ON CLOTHES. DO NOT
BREATHE DUST. WHEN HANDLING, USE PROPER PROTECTIVE
CLOTHING/EQUIPMENT.
============= Exposure Controls/Personal Protection =============
Respiratory Protection:IF ENGINEERING CONTROLS FAIL OR NON-ROUTINE USE
OR AN EMERGENCY OCCURS;WEAR AN MSHA/NIOSH APPROVED RESPIRATOR
W/HEPA FILTER OR AN AIR-SUPPLIED RESPIRATOR OR SCBA,AS REQUIRED.USE
IN ACCORDANCE WITH 29 CFR 1910.134 & MFR'S RECOMMENDATIONS.
Ventilation:LOCAL VENTILATION REQUIRED WHEN USING RAW MATERIAL; USE IN
A LAB HOOD.
Protective Gloves:PLASTIC OR RUBBER.
Eye Protection:SAFETY GLASSES/CHEMICAL SPLASH GOGGLES.
Other Protective Equipment:NONE SPECIFIED BY MANUFACTURER. DLA-HMIS:
EYE WASH STATION & SAFETY SHOWER.
Work Hygienic Practices:WASH HANDS AFTER HANDLING AND BEFORE EATING,
DRINKING, OR SMOKING. LAUNDER CONTAMINATED CLOTHES BEFORE REUSE.
Supplemental Safety and Health
NDC NUMBER NDC00004-1506-03. NOTE: MFR MSDS WAS WRITTEN FOR "PURE"
PRODUCT (>98.5%); THIS NSN IS FOR A 5% CREAM IN A TUBE. EXAMPLE IS
THAT LD50 (ORAL RAT) IS FOR "PURE" 5-FLUOROURCIL, NOT FOR 5% CREAM
OF IT. SO.... MSDS DATA MAY BE MISLEADING FOR PRODUCT IN SUPPLY
SYSTEM (OVERSTATEMENT).
================== Physical/Chemical Properties ==================
HCC:N1
Melt/Freeze Pt:M.P/F.P Text:540F,282C
Decomp Temp:Decomp Text:540F,282C
Solubility in Water:MODERATE
Appearance and Odor:WHITE CRYSTALLINE POWDER (IS CREAM IN TUBE THIS
NSN); ODORLESS.
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
OXIDIZING AGENTS, STRONG BASES.
Stability Condition to Avoid:AVOID ELEVATED TEMPERATURES AND CONTACT
WITH WATER, INCOMPATIBLE MATERIALS.
Hazardous Decomposition Products:CARBON MONOXIDE, CARBON DIOXIDE,
HYDROGEN FLUORIDE, OXIDES OF NITROGEN.
Conditions to Avoid Polymerization:WILL NOT OCCUR.
==================== Disposal Considerations ====================
Waste Disposal Methods:DECONTAMINATE OR DISPOSE OF ALL PROTECTIVE
CLOTHING AND EQUIPMENT. DISPOSE OF IN ACCORDANCE WITH LOCAL, STATE
AND FEDERAL REGULATIONS. MATERIAL IS SUITABLE FOR INCINERATION. NOT
REGULATED UNDER RCRA.
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.
*** END OF RECORD *** |
|
|