LD50 LC50 Mixture:ORAL LD50 (RAT): >10 G/KG (SEE SUPP)
Routes of Entry: Inhalation:YES Skin:NO Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:GLUCOCORTICOIDS AFFECT
CARBOHYDRATE/PROTEIN/FAT METABOLISM & FUNCTIONS OF CARDIOVASCULAR
SYSTEM/KIDNEYS/SKELETAL MUSCLE/NERVOUS SYSTEM/OTHER ORGANS &
TISSUES. MAY MODIFY BODY'S IMMUNE RESPONSE TO DIVE RSE STIMULI.
OVEREXPOSURE MAY CAUSE PITUITARY-ADRENAL SUPPRESSION, CUSHING'S
SYNDROME (SEE SUPP)
Explanation of Carcinogenicity:NONE
Effects of Overexposure:MENTAL SYMPTOMS, MUSCULAR WEAKNESS, FATIGUE,
ACNE, ELEVATION OF BLOOD PRESSSURE, SALT & WATER RETENTION.
Medical Cond Aggravated by Exposure:LATENT TUBERCULOSIS, SECONDARY EYE
INFECTIONS, MASK SOME SIGNS OF INFECTION, HYPERSENSITIVITY TO THIS
MATERIAL MAY RESULT, HYPOTHYROIDISM, CIRRHOSIS.
======================= First Aid Measures =======================
Eyes: FLUSH W/WATER FOR 15 MINS. SKIN: WASH W/SOAP & WATER.
INHALATION: REMOVE TO FRESH AIR. OBTAIN MEDICAL ATTENTION IN ALL
CASES.
===================== Fire Fighting Measures =====================
Flash Point:NON-FLAMMABLE
Extinguishing Media:WATER, CO2, DRY CHEMICAL.
Fire Fighting Procedures:WEAR SELF CONTAINED BREATHING APPARATUS & FULL
BODY PROTECTIVE EQUIPMENT.
Unusual Fire/Explosion Hazard:NONE
Spill Release Procedures:PROVIDE VENTILATION & PERSONAL PROTECTIVE
EQUIPMENT. KEEP PRODUCT OUT OF DRAINS & PREVENT ENTRY TO
SURFACE/GROUND WATER & SOIL. SMALL: ABSORB W/PAPER
TOWELS/APPROPRIATE MEDIA. LARGE: VACUUM/SCOOP UP & PLACE IN A
SUITABLE CONTAINER.
====================== Handling and Storage ======================
Handling and Storage Precautions:STORE IN A COOL, DRY PLACE & PROTECT
FROM LIGHT.
Other Precautions:AVOID CONTACT W/SKIN, EYES & CLOTHING. KEEP OUT OF
REACH OF CHILDREN.
Respiratory Protection:NONE REQUIRED.
Ventilation:LOCAL EXHAUST.
Protective Gloves:RUBBER
Eye Protection:SAFETY GLASSES W/SIDE SHIELDS
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
REUSE. WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
ORAL LD50 INFORMATION IS FOR METHYLPREDNISOLONE ACETATE. HEALTH HAZARDS
CONT'D: INCREASED SUSCEPTIBILITY TO INFECTIONS W/SUPPRESSION OF
INFLAMMATORY RESPONSE/GLAUCOMA W/POSSIBLE OPTIC NERVE DAMAGE/PEP
TIC ULCERS/INCREASED POTASSIUM & CALCIUM
EXCRETION/OSTEOPOROSIS/CATARACTS/HYPERGLYCEMIA/GLYCOSURIA/MENSTRUAL
DISORDERS.
Waste Disposal Methods:DISPOSE OF BY INCINERATION IAW/INTERNATIONAL,
FEDERAL, STATE & LOCAL REGULATIONS.
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.