Routes of Entry: Inhalation:YES Skin:NO Ingestion:NO
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:NONE EXPECTED FROM HANDLING INTACT
VIALS. IN CLINICAL USE, UROKINASE CONVERTS PLASMINOGEN TO PLASMIN
TO BREAK DOWN BLOOD CLOTS.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:NONE EXPECTED FROM HANDLING INTACT VIALS.
CLINICAL DATA SUGGEST INCREASES IN CLOTTING PARAMETER SUCH AS
THROMBIN TIME, PROTHROMBIN TIME & ACTIVATED PARTIAL THROMBOPLASTIN
TIME, BLEEDING & RARELY ALLER GIC REACTIONS, BRONCHOSPASM, RASHES,
FEVER.
Medical Cond Aggravated by Exposure:BLEEDING CONDITIONS,
HYPERSENSITIVITY TO UROKINASE, RECENT CEREBROVASCULAR
ACCIDENTS/INTRACRANIAL/SPINAL SURGERY, INTRACRANIAL NEOPLASMS,
ABNORMALITIES/DISEASES OF BLOOD FORMING TISSUES.
======================= First Aid Measures =======================
First Aid:INHALATION: REMOVE TO FRESH AIR. SKIN/EYES: FLUSH W/COPIOUS
AMOUNTS OF WATER. NO KNOWN ANTIDOTE. PROVIDE SYMPTOMATIC/SUPPORTIVE
CARE AS NEEDED. OBTAIN MEDICAL ATTENTION IN ALL CASES.
===================== Fire Fighting Measures =====================
Extinguishing Media:USE MEDIA APPROPRIATE FOR PRIMARY CAUSE OF FIRE.
Solubility in Water:COMPLETE
Appearance and Odor:STERILE LYOPHILIZED WHITE POWDER PREPARATION IN A
VIAL.
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
NONE UNDER NORMAL USE.
Stability Condition to Avoid:NONE UNDER NORMAL USE.
Hazardous Decomposition Products:OXIDES OF NITROGEN.
Waste Disposal Methods:DISPOSE OF IAW/FEDERAL, STATE & LOCAL
REGULATIONS.
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.