Material Safety Data Sheet
Revision: 11/25/2002
Formamide Glycerol and
Hazard information is provided for compliance with both the UK Chemicals
Tris-HCl
(Hazard Information and Packaging) (CHIP) Regulations and the US Hazard
Communication Standard (HCS)
IDENTIFICATION OF THE PRODUCT NAME: PRODUCT CODE: EEC NUMBER:
SUBSTANCE/PREPARATION Fluorescent Thermo Sequenase Cycle Sequencing Kit 79260 None
AND COMPANY
SUPPLIER: Emergency Contact:
USB Corporation, 26111 Miles Road, Cleveland, Ohio 44128 Phone: (216) 765-5000 Chemtrec (800) 424-9300
Outside USA & Canada 703 527 3887
COMPOSITION/
HAZARDOUS COMPONENTS HAZARD CAS NO. %WT TLV CHIP R & S Phrases
Formamide in 79269 75-12-7 95% 10 ppm R:61May cause harm to the
(ACGIH) unborn child.
S:53 Avoid exposure-Obtain
special instructions before use.
S:45 In case of accident or if
you feel unwell seek medical
advice immediately (show label
where possible).
Glycerol in 79268 56-81-5 50% 10mg/m3 R:36/37/38 Irritating to eyes,
(ACGIH) respiratory system and skin.
S:26 In case of contact with
eyes, rinse immediately with
plenty of water and seek
medical advice.
Tris-HCl in 79261 1185-53-1 ~2.4% --- R:36/37/38 Irritating to eyes,
respiratory system and skin.
S:23 Do not breathe vapour.
S:36/37 Wear suitable
protective clothing and gloves.
HAZARDS IDENTIFICATION CHIP
Formamide: Toxic to Reproduction, Category 2. Glycerol, Tris-HCl: Irritant.
HCS
Formamide: Teratogen. Glycerol, Tris-HCl: Irritant.
FIRST-AID MEASURES EYES: Flush with water for 15 minutes. Seek medical advice if irritation persists.
SKIN: Flush with water, then wash thoroughly with soap and water. Remove contaminated clothing and wash
before reuse. Seek medical attention if irritation persists.
INHALATION: Remove the victim from exposure and move to fresh air. If breathing is difficult, give oxygen. If
not breathing, give artificial respiration. Keep victim quiet and warm. Seek immediate medical attention.
INGESTION: Drink water and seek immediate medical attention. Avoid alcoholic beverages. Never give
anything by mouth to an unconscious person.
This data sheet is based upon information believed to be reliable. The Company makes no statement or warranty as to the accuracy or completeness of the information
contained herein which is offered for your consideration, investigation and verification. Any use of the information contained in this data sheet must be determined by the user
to be in accordance with appropriate applicable regulations.
For Further Asia Pacific Canada Former Soviet Union Japan Norway Spain USA
Information, +852 2811 8693 1 800 463 5800 +7 (095) 232 0250 81 3 5331 9337 63 89 23 10 935 944 950 USB Corporation
contact your (216) 765-5000
local USB Australia Central and East Europe France Latin America Portugal Sweden If purchased from
authorized +61 2 9894 5188 +43 1 982 3826 0169 18 28 00 +55 11 3667 5700 01 417 70 35 018 164000 Amersham Biosciences
distributor, use 1 800 526 3593
Amersham Austria Denmark Germany Middle East and Africa South East Asia Switzerland
Biosciences 01 576 0616 10 +45 4516 2400 07 61 49 03 0 +30 (1) 96 00 687 60 3 724 2080 01 802 81 50
Belgium Finland Italy Netherlands South East Europe UK
0800 73888 358 (9) 512 3940 02 27322 1 0165 580 410 +43 (1) 982 3826 0800 515313
MSDS information may be continued on back of page.
FIRE-FIGHTING INFORMATION Use media suitable to extinguish the supporting or surrounding fire. Wear NIOSH (or equivalent) approved self
contained breathing apparatus. For small fires only: use carbon dioxide, dry powder or foam. Fires involving
Formamide are likely to produce very toxic gases such as carbon monoxide and ammonia, which should not be
inhaled.
Flash Point = 154掳C (310掳F) for Formamide; 193掳C (379.4掳F) for Glycerol; No data available for Tris-HCl.
ACCIDENTAL RELEASE MEASURES Wear appropriate protective equipment and clothing including lab coat, safety glasses and gloves. Dike the
material with a suitable inert absorbent. Place the waste in an appropriate container. Avoid contact of the
material with skin or eyes. Use adequate ventilation.
HANDLING AND STORAGE Wear suitable protective clothing including lab coat, safety glasses and gloves. Wash thoroughly after handling.
Use with adequate ventilation. Store at -20掳C.
PERSONAL PROTECTION Wear appropriate personal protective equipment and clothing including lab coat, safety glasses, Neprene or
other chemical resistant gloves and NIOSH-approved respirator. A qualified industrial hygienist should evaluate
the need for respiratory protection. Use respiratory protection approved by NIOSH (or equivalent) and
appropriate to the hazard. Avoid contact of material with skin or eyes. Mechanical ventilation or local exhaust
as needed to control exposure to dust, vapors or mists. Access to a safety shower and eye-wash. Pregnant
women and women of child bearing age should minimize contact and exposure to Formamide.
PHYSICAL AND CHEMICAL Appearance: Kit containing vials of solutions.
PROPERTIES Boiling Point: Formamide = 210掳C; Glycerol = 288掳C; Tris-HCl = No information available.
Melting Point: Formamide = 2 to 3掳C; Glycerol = 20掳F; Tris-HCl = No information available.
Vapor Pressure: Formamide = 0.08mm at 20掳C; Glycerol = .0025 mm at 5掳C; Tris-HCl = No
information available.
Vapor Density: Formamide = 1.55; Glycerol = 3.17; Tris-HCl = No information available.
Specific Gravity: Formamide = 1.134; Glycerol = 1.26; Tris-HCl = No information available.
Evaporation Rate: No information available.
Solubility (Water): Formamide = insoluble in water; Glycerol = Miscible in water; Tris-HCl = No info.
available.
Solubility (Other): No information available.
STABILITY AND REACTIVITY Product is stable.
Formamide: Formamide decomposes at temperatures above 180掳C and is incompatible with alkali and acids.
Hazardous decomposition products may include carbon monoxide and nitrogen oxides. Hazardous
polymerization will not occur.
Glycerol: Glycerol is stable under normal conditions. Avoid strong oxidizing agent including mixtures with
hydrogen peroxide, potassium permanganate, calcium hypochlorite, nitric acid, sulfuric acid, perchloric
acid and lead oxide.
Tris-HCl: Avoid excessive heat. Incompatible with oxidizing materials and may produce toxic fumes upon
decomposition.
TOXICOLOGICAL INFORMATION Formamide: May cause irritation to skin, eyes and mucous membranes. Vapors are irritating to nose, throat and
lungs. In animal studies, Formamide has caused embryotoxicity and birth defects at levels high enough to
cause maternal toxicity. Defects and fetal deaths were seen. Formamide may be absorbed through the
skin. Irritation, mutation, reproductive effects and toxicity effects data are listed under RTECS
LQ0525000. Oral rat LD50 = 5577 mg/kg(1967).
Glycerol: May cause irritation to eyes, skin and mucous membranes. Ingestion may cause irritation of the
gastrointestinal tract and diarrhea. Ingestion of large quantities may cause nausea and vomiting. Irritation,
mutation, reproductive effects and toxicity data for Glycerol listed in RTECS under MA8050000. Oral rat
LD50 = 12600 mg/kg(1945).
Tris-HCl: May cause irritation to the eyes, skin and mucous membranes. Contact may cause redness, swelling
and pain. Excessive inhalation may cause irritation, cough and shortness of breath. Ingestion or excessive
exposure may lead to nausea, vomiting and diarrhea. Large amounts may cause weakness, collapse and
coma.
ECOLOGICAL INFORMATION No information available.
DISPOSAL CONSIDERATIONS Dispose of material in accordance with applicable local, state, and federal regulations.
TRANSPORTATION INFORMATION No applicable information.
REGULATORY INFORMATION RCRA - No applicable information.
SARA 302 - No applicable information.
SARA 313 - No applicable information.
EPA TSCA Section 8(b) - For Formamide and Glycerol: Chemical Inventory.
8(d) - For Formamide and Glycerol: unpublished health/safety studies.
Exposure Limits - For Formamide: ACGIH TLV-TWA: 10 ppm (skin).
NIOSH REL to Formamide-air: 10H TWA 10 ppm (Sk).
For Glycerol: ACGIH TLV-TWA: 10 mg/m3.
OSHA PEL (Gen Indu): 8H TWA 15 mg/m3, total dust.
OSHA PEL (Gen Indu): 8H TWA 5 mg/m3, respirable fraction.
California Proposition 65 - No applicable information.
|