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Material Safety Data Sheet
acc. to ISO/DIS 11014
Printing date 06/20/2008 Reviewed on 06/20/2008
* 1 Identification of substance
Trade name: TCEP
Article number: P5481
Application of the substance / the preparation Laboratory chemicals
Manufacturer/Supplier:
Promega Corporation
2800 Woods Hollow Road
Madison, WI 53711
U.S.A.
1-800-356-9526 or (608)-274-4330
MSDS author: Regulatory.Affairs@promega.com
Emergency information:
CHEMTREC 1-800-424-9300
for call originating outside the United States dial 001-703-527-3887
2 Composition/Data on components
Chemical characterization:
CAS No. Description
5961-85-3 Tris(2-carboxyethyl)phosphine hydrochloride
(TCEP)
* 3 Hazards identification
Hazard description:
C Corrosive
Information pertaining to particular dangers for man and environment:
Causes burns.
Classification system:
The classification was made according to the latest editions of international substances lists, and is expanded
upon by company and technical literature data.
NFPA ratings (scale 0 - 4)
Health = 3
Fire = 0
Reactivity = 0
HMIS-ratings (scale 0 - 4)
Health = 3
Fire =0
Reactivity = 0
OSHA Hazard Overview (Criteria according to 29CFR1910.1200):
Highly Toxic
(Contd. on page 2)
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Page 2/6
Material Safety Data Sheet
acc. to ISO/DIS 11014
Printing date 06/20/2008 Reviewed on 06/20/2008
Trade name: TCEP
(Contd. of page 1)
Corrosive
Primary route(s) of entry:
Dermal
Inhalation
Oral
Target Organ(s): Not applicable or unknown
* 4 First aid measures
General information: Immediately remove any clothing soiled by the product.
After inhalation: In case of unconsciousness place patient stably in side position for transportation.
After skin contact: Immediately wash with water and soap and rinse thoroughly.
After eye contact: Rinse opened eye for several minutes under running water.
After swallowing: Drink copious amounts of water and provide fresh air. Immediately call a doctor.
5 Fire fighting measures
Suitable extinguishing agents:
CO2, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam.
6 Accidental release measures
Person-related safety precautions: Wear protective equipment. Keep unprotected persons away.
Measures for environmental protection: Do not allow to enter sewers/ surface or ground water.
Measures for cleaning/collecting:
Use neutralizing agent.
Dispose contaminated material as waste according to item 13.
Ensure adequate ventilation.
* 7 Handling and storage
Handling:
Information for safe handling: Thorough dedusting.
Information about protection against explosions and fires: No special measures required.
Storage:
Requirements to be met by storerooms and receptacles: No special requirements.
Information about storage in one common storage facility: Not required.
Further information about storage conditions: Keep receptacle tightly sealed.
* 8 Exposure controls and personal protection
Components with limit values that require monitoring at the workplace: Not required.
Additional information: The lists that were valid during the creation were used as basis.
Personal protective equipment:
General protective and hygienic measures:
Keep away from foodstuffs, beverages and feed.
Immediately remove all soiled and contaminated clothing.
Wash hands before breaks and at the end of work.
(Contd. on page 3)
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Material Safety Data Sheet
acc. to ISO/DIS 11014
Printing date 06/20/2008 Reviewed on 06/20/2008
Trade name: TCEP
(Contd. of page 2)
Avoid contact with the eyes.
Avoid contact with the eyes and skin.
Breathing equipment: Not required.
Protection of hands:
Protective gloves
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation
Material of gloves
The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and
varies from manufacturer to manufacturer.
Eye protection: Tightly sealed goggles
9 Physical and chemical properties
General Information
Solid
Form:
Colorless
Color:
Characteristic
Odor:
Change in condition
Melting point/Melting range: Undetermined.
Boiling point/Boiling range: Undetermined.
Not applicable.
Flash point:
Flammability (solid, gaseous): Product is not flammable.
Product does not present an explosion hazard.
Danger of explosion:
Not determined.
Density:
Solubility in / Miscibility with
Insoluble.
Water:
0.0 %
Organic solvents:
10 Stability and reactivity
Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications.
Dangerous reactions No dangerous reactions known.
Dangerous products of decomposition: No dangerous decomposition products known.
* 11 Toxicological information
Acute toxicity:
Primary irritant effect:
on the skin: Caustic effect on skin and mucous membranes.
on the eye:
Strong caustic effect.
Irritating effect.
Sensitization: No sensitizing effects known.
(Contd. on page 4)
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Material Safety Data Sheet
acc. to ISO/DIS 11014
Printing date 06/20/2008 Reviewed on 06/20/2008
Trade name: TCEP
(Contd. of page 3)
Additional toxicological information:
Swallowing will lead to a strong caustic effect on mouth and throat and to the danger of perforation of esophagus
and stomach.
12 Ecological information
General notes:
Water hazard class 1 (Self-assessment): slightly hazardous for water
Do not allow undiluted product or large quantities of it to reach ground water, water course or sewage system.
Must not reach bodies of water or drainage ditch undiluted or unneutralized.
13 Disposal considerations
Product:
Recommendation:
Must not be disposed of together with household garbage. Do not allow product to reach sewage system.
Uncleaned packagings:
Recommendation: Disposal must be made according to official regulations.
* 14 Transport information
Contact Promega Safety Department for additional transportation information
DOT regulations:
8
Hazard class:
UN3261
Identification number:
II
Packing group:
Proper shipping name (technical name): CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S.
Land transport ADR/RID (cross-border):
8 Corrosive substances
ADR/RID class:
3261
UN-Number:
II
Packaging group:
3261 CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S.
Description of goods:
Maritime transport IMDG:
-
IMDG Class:
No
Marine pollutant:
Air transport ICAO-TI and IATA-DGR:
-
ICAO/IATA Class:
* 15 Regulations
Sara
Section 355 (extremely hazardous substances):
Substance is not listed.
Section 313 (Specific toxic chemical listings):
Substance is not listed.
(Contd. on page 5)
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Material Safety Data Sheet
acc. to ISO/DIS 11014
Printing date 06/20/2008 Reviewed on 06/20/2008
Trade name: TCEP
(Contd. of page 4)
TSCA (Toxic Substances Control Act):
Substance is not listed.
Proposition 65
Chemicals known to cause cancer:
Substance is not listed.
Chemicals known to cause reproductive toxicity for females:
Substance is not listed.
Chemicals known to cause reproductive toxicity for males:
Substance is not listed.
Chemicals known to cause developmental toxicity:
Substance is not listed.
Cancerogenity categories
EPA (Environmental Protection Agency)
Substance is not listed.
IARC (International Agency for Research on Cancer)
Substance is not listed.
NTP (National Toxicology Program)
Substance is not listed.
TLV (Threshold Limit Value established by ACGIH)
Substance is not listed.
MAK (German Maximum Workplace Concentration)
Substance is not listed.
NIOSH-Ca (National Institute for Occupational Safety and Health)
Substance is not listed.
OSHA-Ca (Occupational Safety & Health Administration)
Substance is not listed.
Product related hazard informations:
The product has been classified and marked in accordance with directives on hazardous materials.
Hazard symbols:
C Corrosive
Risk phrases:
Causes burns.
Safety phrases:
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Take off immediately all contaminated clothing.
Wear suitable protective clothing, gloves and eye/face protection.
National regulations:
Water hazard class: Water hazard class 1 (Self-assessment): slightly hazardous for water.
* 16 Other information
This information is based on our present knowledge. However, this shall not constitute a guarantee for any
specific product features and shall not establish a legally valid contractual relationship.
(Contd. on page 6)
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Material Safety Data Sheet
acc. to ISO/DIS 11014
Printing date 06/20/2008 Reviewed on 06/20/2008
Trade name: TCEP
(Contd. of page 5)
Department issuing MSDS:
Promega Corporation
Environmental Health and Safety Department
2800 Woods Hollow Road
Madison, WI
Ph:(608)274-4330
* Data compared to the previous version altered.
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