SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 09/NOV/2004
Date Updated: 13/MAR/2004
Version 1.3
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name AMARANTH
Product Number A1016
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
AMARANTH 915-67-3 213-022-2 None
Formula C20H11N2Na3O10S3
Molecular Weight 604.48 AMU
Synonyms Acetacid Red 2BR * Acid Amaranth * Acid Amaranth
I * Acid Amaranth N * Acid Leather Red I 2BW *
Acid Leather Rubine S * Acid Red 27 * Acilan Red
SE * Aizen Amaranth * Amacid Amaranth * Amarant
(Czech) * Amaranth * Amaranth A * Amaranth B *
Amaranth BPC * Amaranthe * Amaranthe USP
(biological stain) * Amaranth Extra * Amaranth
Lake * Amaranth S * Amaranth S Specially Pure *
Amaranth WD * Azo Red R * Azo Rubine SF * Azo
Rubine S.FQ * Azorubin S * Azo Ruby S * Bordeaux
* Bordeaux S * Bordeaux S Extra Conc. A Export *
Bordeaux S Extra Pure A * Calcocid Amaranth *
Canacert Amaranth * Certicol Amaranth S * Cerven
kysela 27 (Czech) * Cerven potravinarska 9
(Czech) * C.I. 184 * C.I. 16185 * C.I. Acid Red
27 * C.I. Acid Red 27, trisodium salt * C.I.
Food Red 9 * Cilefa Rubine 2B * Daishiki
Amaranth * D and C Red 2 * Dolkwal Amaranth *
Dye FDC Red 2 * Dye Red Raspberry * E 123 *
Edicol Amaranth * Edicol Supra Amaranth A * EEC
No. 123 * Eurocert Amaranth * Fast Red * FD and
C Red No. 2 * FD&C Red No. 2 - Aluminium Lake *
Food Red 2 * Food Red 9 * Fruit Red A Geigy * HD
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Irritating to eyes, respiratory system and skin.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
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PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range N/A
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Sulfur oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: QJ6550000
ACUTE TOXICITY
LD50
Intraperitoneal
Rat
1 GM/KG
LD50
Intravenous
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Rat
1 GM/KG
LD50
Intraperitoneal
Mouse
1 GM/KG
Remarks: Behavioral:Somnolence (general depressed activity).
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract. May be harmful if inhaled.
Ingestion: May be harmful if swallowed.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
Rat
Route of Application: Oral
Exposure Time: 14W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Gastrointestinal:Tumors. Blood:Lymphomas including
Hodgkin's disease.
Rat
Route of Application: Oral
Exposure Time: 78W
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Blood:Lymphomas including Hodgkin's disease.
Rat
Route of Application: Oral
Exposure Time: 78W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Gastrointestinal:Tumors.
IARC CARCINOGEN LIST
Rating: Group 3
CHRONIC EXPOSURE - MUTAGEN
Mouse
2 GM/KG
Oral
DNA damage
Hamster
1 GM/L
48H
Cell Type: fibroblast
Cytogenetic analysis
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Hamster
2 GM/L
Cell Type: lung
Cytogenetic analysis
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 65 MG/KG
Route of Application: Oral
Exposure Time: (MULTIGENERATIONS)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Mouse
Dose: 4550 UL/KG
Route of Application: Oral
Exposure Time: (4W MALE/4W PRE-2W POST)
Result: Effects on Embryo or Fetus: Other effects to embryo.
Species: Hamster
Dose: 100 MG/KG
Route of Application: Intravenous
Exposure Time: (8D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat Rat
Dose: 548 MG/KG 548 MG/KG
Route of Application: Oral Oral
Exposure Time: (52W PRE) (52W PRE)
Result: Maternal Effects: Menstrual cycle changes or disorders.
Maternal Effects: Menstrual cycle changes or disorders.
Species: Rat Rat
Dose: 547 MG/KG 547 MG/KG
Route of Application: Oral Oral
Exposure Time: (MULTIGENERATIONS) (MULTIGENERATIONS)
Result: Effects on Fertility: Female fertility index (e.g., #
females pregnant per # sperm positive females; # females
pregnant per # females mated ). Effects on Newborn: Live birth
index (# fetuses per litter; measured after birth). Effects on
Fertility: Female fertility index (e.g., # females pregnant per
# sperm positive females; # females pregnant per # females mated
). Effects on Newborn: Live birth index (# fetuses per litter;
measured after birth).
Species: Rat Rat
Dose: 33 MG/KG 33 MG/KG
Route of Application: Oral Oral
Exposure Time: (1-22D PREG) (1-22D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Fertility: Litter size (e.g.; # fetuses per litter;
measured before birth). Effects on Fertility: Post-implantation
mortality (e.g., dead and/or resorbed implants per total number
of implants). Effects on Fertility: Litter size (e.g.; # fetuses
per litter; measured before birth).
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Species: Rat Rat
Dose: 296 MG/KG 296 MG/KG
Route of Application: Oral Oral
Exposure Time: (MULTIGENERATIONS) (MULTIGENERATIONS)
Result: Effects on Newborn: Viability index (e.g., # alive at
day 4 per # born alive). Effects on Newborn: Growth statistics
(e.g., reduced weight gain). Effects on Newborn: Viability index
(e.g., # alive at day 4 per # born alive). Effects on Newborn:
Growth statistics (e.g., reduced weight gain).
Species: Rat Rat
Dose: 548 MG/KG 548 MG/KG
Route of Application: Oral Oral
Exposure Time: (52W MALE) (52W MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Spermatogenesis (including genetic material, sperm
morphology,motility, and count).
Species: Mouse Mouse
Dose: 3528 UG/KG 3528 UG/KG
Route of Application: Oral Oral
Exposure Time: (4W MALE/4W PRE-3W POST) (4W MALE/4W PRE-3W POST)
Result: Effects on Newborn: Behavioral. Effects on Newborn:
Behavioral.
Species: Mouse Mouse
Dose: 4900 UL/KG 4900 UL/KG
Route of Application: Oral Oral
Exposure Time: (4W MALE/4W PRE-3W POST) (4W MALE/4W PRE-3W POST)
Result: Effects on Newborn: Live birth index (# fetuses per
litter; measured after birth). Effects on Newborn: Live birth
index (# fetuses per litter; measured after birth).
Species: Mouse Mouse
Dose: 12 ML/KG 12 ML/KG
Route of Application: Oral Oral
Exposure Time: (4W MALE/4W PRE-4D POST) (4W MALE/4W PRE-4D POST)
Result: Effects on Newborn: Behavioral. Effects on Newborn:
Behavioral.
Species: Mouse Mouse
Dose: 250 MG/KG 250 MG/KG
Route of Application: Intraperitoneal Intraperitoneal
Exposure Time: (1D MALE) (1D MALE)
Result: Effects on Fertility: Male fertility index (e.g., #
males impregnating females per # males exposed to fertile
nonpregnant females). Effects on Fertility: Pre-implantation
mortality (e.g., reduction in number of implants per female;
total number of implants per corpora lutea). Effects on
Fertility: Male fertility index (e.g., # males impregnating
females per # males exposed to fertile nonpregnant females).
Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
Species: Rabbit Rabbit
Dose: 16500 UG/KG 16500 UG/KG
Route of Application: Oral Oral
Exposure Time: (6-16D PREG) (6-16D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
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Effects on Fertility: Post-implantation mortality (e.g., dead
and/or resorbed implants per total number of implants).
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xi
Irritant.
R-PHRASES: 36/37/38
Irritating to eyes, respiratory system and skin.
S-PHRASES: 36/37/39
Wear suitable protective clothing, gloves, and eye/face
protection.
SWITZERLAND
SWISS POISON CLASS: 5
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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