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MSDS 
:
 Tris(hydroxymethyl)aminomethane hydrochloride
CAS 
:
 1185-53-1
SYNONYMS 
:
 2-Amino-2-(hydroxymethyl)-1,3-propanediol hydrochloride; Tris     hydrochloride.
**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****

+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 1185-53-1 |Tris(hydroxymethyl)aminomethane hydroc| >95 | 214-684-5 |
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: None Listed.
Risk Phrases: None Listed.

**** SECTION 3 - HAZARDS IDENTIFICATION ****

EMERGENCY OVERVIEW
Hygroscopic (absorbs moisture from the air).

Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and
diarrhea. The toxicological properties of this substance have not
been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties
of this substance have not been fully investigated.
Chronic:
Not available.

**** SECTION 4 - FIRST AID MEASURES ****

Eyes:
Flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Flush skin with plenty of water for at least 15 minutes while
removing contaminated clothing and shoes. Get medical aid if
irritation develops or persists. Wash clothing before reuse.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical
aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If not
breathing, give artificial respiration. If breathing is difficult,
give oxygen. Get medical aid.
Notes to Physician:

**** SECTION 5 - FIRE FIGHTING MEASURES ****

General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or
alcohol-resistant foam.

**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****

General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective
Equipment section. Sweep up or absorb material, then place into a
suitable clean, dry, closed container for disposal. Avoid generating
dusty conditions. Provide ventilation.

**** SECTION 7 - HANDLING and STORAGE ****

Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Use with adequate ventilation. Minimize dust
generation and accumulation. Avoid contact with eyes, skin, and
clothing. Keep container tightly closed. Avoid ingestion and
inhalation.
Storage:
Store in a cool, dry, well-ventilated area away from incompatible
substances. Keep containers tightly closed. Store protected from
moisture.

**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****

Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits
CAS# 1185-53-1:


Personal Protective Equipment

Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use. Follow the OSHA
respirator regulations found in 29 CFR 1910.134 or
European Standard EN 149. Use a NIOSH/MSHA or
European Standard EN 149 approved respirator if
exposure limits are exceeded or if irritation or
other symptoms are experienced.

**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****

Physical State: Solid
Color: white
Odor: none reported
pH: 3.5-5 (0.5M sol.)
Vapor Pressure: Negligible
Viscosity: Not available.
Boiling Point: Not applicable.
Freezing/Melting Point: 150-152 deg C (dec)
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: N/A
Explosion Limits, upper: N/A
Decomposition Temperature: 150-152 deg C
Solubility in water: Soluble in water.
Specific Gravity/Density: Not available.
Molecular Formula: C4H11NO3.HCl
Molecular Weight: 157.60

**** SECTION 10 - STABILITY AND REACTIVITY ****

Chemical Stability:
Stable. However, may decompose if heated. Stable under normal
temperatures and pressures.
Conditions to Avoid:
Moisture, excess heat.
Incompatibilities with Other Materials:
Bases, oxidizing agents, acids, aldehydes, copper, brass, and
aluminum.
Hazardous Decomposition Products:
Hydrogen chloride, chlorine, nitrogen oxides, carbon monoxide, carbon
dioxide, ammonia and/or derivatives.
Hazardous Polymerization: Has not been reported.

**** SECTION 11 - TOXICOLOGICAL INFORMATION ****

RTECS#:
CAS# 1185-53-1 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Tris(hydroxymethyl)aminomethane hydrochloride -
Not listed by ACGIH, IARC, or NTP.

**** SECTION 12 - ECOLOGICAL INFORMATION ****



**** SECTION 13 - DISPOSAL CONSIDERATIONS ****

Dispose of in a manner consistent with federal, state, and local regulations.

**** SECTION 14 - TRANSPORT INFORMATION ****

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

**** SECTION 15 - REGULATORY INFORMATION ****

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 1185-53-1: No information available.
Canada
CAS# 1185-53-1 is listed on Canada's DSL List.
CAS# 1185-53-1 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 1185-53-1 is listed on the TSCA inventory.

**** SECTION 16 - ADDITIONAL INFORMATION ****

MSDS Creation Date: 7/15/1999 Revision #2 Date: 3/04/2003

The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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