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MSDS  : Antipyrine, 4-(isopropylamino)-
CAS  : 3615-24-5
SYNONYMS  : * Isopirina * Isopropylaminoantipyrine * 4-(Isopropylamino)antipyrine * 4-Isopropylamino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one * Isopropylaminophenazon * Isopropylaminophenazone * 4-Isopropylamino-1-phenyl-2,3-dimethyl-3-pyrazolin-5-one * Isopyrin * Isopyrine * 4-Monoisopropylamino-1-phenyl-2,3-dimethyl-5-pyrazolone * 1-Phenyl-2,3-dimethyl-4-(isopropylamino)-2-pyrazolin-5-one * 1-Phenyl-2,3-dimethyl-4-isopropylaminopyrazolone * 3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-((1-methylethyl)amino)-2-phenyl- * Ramifenazone * Tomanol-wirkstoff
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : CD2975000
CHEMICAL NAME : Antipyrine, 4-(isopropylamino)-
CAS REGISTRY NUMBER : 3615-24-5
BEILSTEIN REFERENCE NO. : 0231936
REFERENCE : 5-25-14-00123 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 7
MOLECULAR FORMULA : C14-H19-N3-O
MOLECULAR WEIGHT : 245.36
WISWESSER LINE NOTATION : T5NNVJ A1 BR& DMY1&1 E1
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Isopirina
* Isopropylaminoantipyrine
* 4-(Isopropylamino)antipyrine
* 4-Isopropylamino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
* Isopropylaminophenazon
* Isopropylaminophenazone
* 4-Isopropylamino-1-phenyl-2,3-dimethyl-3-pyrazolin-5-one
* Isopyrin
* Isopyrine
* 4-Monoisopropylamino-1-phenyl-2,3-dimethyl-5-pyrazolone
* 1-Phenyl-2,3-dimethyl-4-(isopropylamino)-2-pyrazolin-5-one
* 1-Phenyl-2,3-dimethyl-4-isopropylaminopyrazolone
* 3H-Pyrazol-3-one,
1,2-dihydro-1,5-dimethyl-4-((1-methylethyl)amino)-2-phenyl-
* Ramifenazone
* Tomanol-wirkstoff

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 715 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 20,1024,1970

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 10,665,1960

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 820 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 10,665,1960

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1070 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 20,1024,1970

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 690 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 10,665,1960

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 370 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 233,365,1958

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 567 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 20,1024,1970

*** END OF RECORD ***
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Antibiotic SF-1670-A 60440-43-9
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Antipyrine, 4-amino-, and sodium nitrite 24428-98-6
Antipyrine, 4-(2-(p-anisoyl)vinyl)- 24428-77-1
Antipyrine, 4,4'-azodi- 102585-65-9
Antipyrine, 4-(2-benzoylpropenyl)- 24428-80-6
Antipyrine, 4-(2-benzoylvinyl)- 15183-03-6
Antipyrine, 4-butyl- 101496-03-1
Antipyrine, 4-sec-butyl- 96974-48-0
Antipyrine, compd. with chloral hydrate (12) 480-30-8
Antibiotic SF 2107 A(sub 1) 81030-78-6
Antipyrine, 4-(2-(p-chlorobenzoyl)vinyl)- 24429-12-7
Antipyrine, 4-((p-chlorophenacylidene)amino)- 24377-61-5
Antipyrine, 4-(2-(diethylamino)ethyl)- 24377-61-5
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Antipyrine, 4-(dimethylamino)- 58-15-1
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Antipyrine, 4-(dimethylamino)-, sodium salt 6062-19-7
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Antipyrine, 4-ethyl- 73791-34-1
Antipyrine, 4-(ethylamino)- 15166-10-6
Antibiotic SF 1306B 52934-72-2
Antipyrine, 4-(2-(p-hydroxybenzoyl)propenyl)-,hydrate 26405-20-9
Antipyrine, 4-isobutyl- 26405-20-9
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Antipyrine, 4-isopropyl- 479-92-5
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Antipyrine, 4-(methylamino)- 519-98-2
Antipyrine, 4-((p-methylphenacylidene)amino)- 24428-96-4
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