*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : ZE6125000
CHEMICAL NAME : 2,6-Xylenol
CAS REGISTRY NUMBER : 576-26-1
LAST UPDATED : 199710
DATA ITEMS CITED : 21
MOLECULAR FORMULA : C8-H10-O
MOLECULAR WEIGHT : 122.18
WISWESSER LINE NOTATION : QR B1 F1
COMPOUND DESCRIPTOR : Tumorigen
Drug
Primary Irritant
SYNONYMS/TRADE NAMES :
* 2,6-Dimethylphenol
* Phenol, 2,6-dimethyl-
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg
REFERENCE :
IHFCAY Industrial Hygiene Foundation of America, Chemical and Toxicological
Series, Bulletin. (Pittsburgh, PA) 1947-69. Volume(issue)/page/year:
6,1,1967
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 296 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPPAF Gigiena Truda i Professional'naya Patologiya v Estonskoi SSR. Labor
Hygiene and Occupational Pathology in the Estonian SSR. (Institut
Eksperimental'noi i Klinicheskoi Meditsiny Ministerstva Zdravookhraneniya
Estonskoi SSR, Tallinn, USSR) V.8- 1972- Volume(issue)/page/year:
8,145,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2325 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 20(4),43,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 450 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 20(4),43,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 920 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 18(2),58,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD691-490
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 80 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - sleep
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 23,1350,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 700 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
33(7-9),329,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IHFCAY Industrial Hygiene Foundation of America, Chemical and Toxicological
Series, Bulletin. (Pittsburgh, PA) 1947-69. Volume(issue)/page/year:
6,1,1967
TYPE OF TEST : LC - Lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : >270 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 20(4),43,1976
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2065 mg/kg/10W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight
Liver - changes in liver weight
Endocrine - changes in spleen weight
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
33(7-9),329,1968
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1470 mg/kg/35W-I
TOXIC EFFECTS :
Liver - other changes
Blood - changes in spleen
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
33(7-9),329,1968
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 22 mg/m3/4H/19W-I
TOXIC EFFECTS :
Liver - liver function tests impaired
Kidney, Ureter, Bladder - other changes in urine composition
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 20(4),43,1976
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1 mg/m3/24H/6D-C
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 48(1),78,1983
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4000 mg/kg/20W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
19,413,1959
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 2 mg/m3;Skin JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - T1638
No. of Facilities: 484 (estimated)
No. of Industries: 3
No. of Occupations: 3
No. of Employees: 1984 (estimated)
No. of Female Employees: 179 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***
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| ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| | NAME | CAS |
|
Xylene, tetranitro-
| 24239-79-0 |
|
Xylenol
| 1300-71-6 |
|
2,3-Xylenol
| 526-75-0 |
|
2,4-Xylenol
| 105-67-9 |
|
2,5-Xylenol
| 95-87-4 |
|
Venom, spider, Latrodectus variolus
| 95-87-4 |
|
2,6-Xylenol
| 576-26-1 |
|
3,4-Xylenol
| 95-65-8 |
|
3,5-Xylenol
| 108-68-9 |
|
4,5-Xylenol, 2-amino-
| 6623-41-2 |
|
3,5-Xylenol, 4-amino-
| 3096-70-6 |
|
2,6-Xylenol, alpha(sup 2),alpha(sup6)-bis(diethylamino)-4-(4-quinolinylamino)-
| 3096-70-6 |
|
2,6-Xylenol, 4-bromo-
| 2374-05-2 |
|
2,4-Xylenol, 6-tert-butyl-
| 1879-09-0 |
|
3,4-Xylenol, 6-tert-butyl-
| 1445-23-4 |
|
2,4-Xylenol, 6,6'-butylidenebis-
| 3772-23-4 |
|
Venom, spider, Loxosceles gaucho
| 3772-23-4 |
|
3,5-Xylenol, 4-chloro-
| 88-04-0 |
|
2,4-Xylenol, 6-chloro-alpha(sup 4)-(dimethylamino)-
| 82965-44-4 |
|
2,6-Xylenol, 4-chloro-alpha(sup 2),alpha(sup2)-di(3,4-xylyl)-
| 64038-53-5 |
|
2,6-Xylenol, 4-chloro-alpha(sup 2)-(methylimino)-
| 63238-79-9 |
|
2,6-Xylenol,4-((7-chloro-4-quinolyl)amino)-alpha,alpha'-di-1-pyrrolidinyl-
| 5201-88-7 |
|
3,4-Xylenol, 6-cyclohexyl-alpha(sup 4)-piperidino-
| 106609-32-9 |
|
3,5-Xylenol, 4-(dimethylamino)-
| 6120-10-1 |
|
2,4-Xylenol, alpha-(dimethylamino)-, hydrochloride
| 6120-10-1 |
|
2,5-Xylenol, alpha-(dimethylamino)-, hydrochloride
| 6120-10-1 |
|
2,6-Xylenol, alpha-(dimethylamino)-, hydrochloride
| 1198-86-3 |
|
Venom, spider, Loxosceles reclusa
| 1198-86-3 |
|
2,4-Xylenol, alpha(sup 4)-(dimethylamino)-6-propyl-,hydrochloride
| 96432-75-6 |
|
2,6-Xylenol,alpha-((3-(dimethylamino)propyl)methylamino)-4-iodo-,dihydrochloride
| 96432-75-6 |
|
2,5-Xylenol, 4,6-dinitro-
| 15968-56-6 |
|
2,6-Xylenol, alpha(sup 2),alpha(sup6)-dipiperidino-4-(4-quinolinylamino)-
| 15968-56-6 |
|
2,3-Xylenol, 6-isopropyl-alpha(sup 2)-morpholino-
| 1715-74-8 |
|
2,6-Xylenol, 4-nitro-
| 2423-71-4 |
|
Xylenol, phosphate (31)
| 25155-23-1 |
|
Xylia xylocarpa (roxb.) Taub., fruit extractSUBSTANCE DEFINITION :Plant belonging to the family MimosaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 25155-23-1 |
|
Xylia xylocarpa (roxb.) Taub., stem bark extractSUBSTANCE DEFINITION :Plant belonging to the family FabaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 25155-23-1 |
|
Xylidine
| 1300-73-8 |
|
Venom, spider, Loxosceles rufipes
| 1300-73-8 |
|
2,3-Xylidine
| 87-59-2 |
|
2,4-Xylidine
| 95-68-1 |
|
2,5-Xylidine
| 95-78-3 |
|
2,6-Xylidine
| 87-62-7 |
|
3,4-Xylidine
| 95-64-7 |
|
3,5-Xylidine
| 108-69-0 |
|
2,4-Xylidine, alpha(sup 4)-(p-aminophenyl)-alpha(sup4)-(4-imino-2,5-cyclohexadien- 1-ylidene)-
| 3248-93-9 |
|
3,4-Xylidine, 6-(beta-carboxypropionyl)-,hydrochloride, hydrate
| 91641-63-3 |
|
2,6-Xylidine, N-(2-(diethylamino)ethyl)-,dihydrochloride
| 78280-29-2 |
|
2,6-Xylidine, N,N-dimethyl-4-(phenylazo)-
| 20557-73-7 |
|
Venom, snake, Trimeresurus flavoviridis, hemorrhagicprinciple 1
| 20557-73-7 |
|
|